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C F Sánchez

Publications and source records attributed to C F Sánchez.

8 recordsLinked to original sources
PubMed1982

Contractile responses and noradrenaline release evoked by serotonin in cat femoral artery: influence of pentobarbital.

1. 5-Hydroxytryptamine (5-HT) induced dose-dependent contractions in the isolated cat femoral artery, which were reduced by LSD, methysergide, phentolamine and reserpine pretreatment (only at low doses). 2. Pentobarbital (PB) and Mn/+ relaxed the arteries previously contracted with 5-HT. These drugs reduced the contraction evoked by this amine as it was Ca2+-suppression. 3. High concentrations of 5-HT and K+ induced tritium release from vessels prelabelled with 3H-noradrenaline. Ca2+-deprivation and PB unmodified the release caused by 5-HT, but that elicited by K+ was abolished. 4. These data indicate that 5-HT-induced contraction is essentially due to direct interaction of this agent with 5-HT-receptors, and that PB interferes with Ca2+ entry to the cell.

Animals↗
PubMed1982

Analysis of the effects of noradrenaline and tyramine in isolated middle cerebral and femoral arteries of cat.

1. Tyramine and noradrenaline (NA) caused dose-dependent contractions in middle cerebral and femoral arteries of cat, which were decreased by phentolamine. 2. Gangliectomy increased the contraction evoked by NA in brain arteries. 3. Reserpine pretreatment and/or gangliectomy reduced the contraction caused by tyramine, the maximal responses being unmodified in the cerebral vessels. 4. Tyramine induced Ca2+-dependent tritium release from brain and femoral arteries, which was reduced by reserpine pretreatment and/or gangliectomy. 5. These data suggest that tyramine has a direct component, apart from an indirect one, in brain arteries. The mechanisms by which NA induces slight contraction in them, including the role of Ca2+, are postulated.

Animals↗
PubMed1979

Release of [3H]noradrenaline induced by 5-hydroxytryptamine from cat pial arteries.

Pial arteries of cats were used to analyse the effects of 5-hydroxytryptamine (5-HT) on the release of [3H]noradrenaline. To achieve this the vessels were preincubated with [3H]noradrenaline and the effect of different concentrations of 5-HT (10(-6), 10(-5), 10(-4) M) on the release of tritium was studied. 5-HT elicited release of radioactivity in a dose-dependent manner. Removal of both superior cervical sympathetic ganglia 15 days before the experiment of pretreatment of the animals with reserpine (3 mg kg-1, total dose) produced a significant decrease in the outflow of tritium induced by 5-HT. In these arteries, the amount of radioactivity retained at the end of the experiment was much diminished. Cocaine (10(-6) M) caused a significant decrease in the tritium efflux induced by 5-HT (1"0(-5) M). These results show that 5-HT has an indirect adrenergic effect in the pial arteries of the cat only at high doses of 5-HT, and confirm that sympathetic innervation of these vessels mainly comes from the superior cervical ganglia.

Animals↗
PubMedDate not supplied

[Telangiectasis: arterial or venous?].

In this work we have tried to elucidate whether telangiectases are dilatations of the arteriolar or the venular sections of the circulation system. To this end, we have made use of resources which have allowed us to study in the first place, the wall of these small vascular dilatations and, in the second place, their content. Through our studies we could determine that telangiectases are originated by dilatation of the venular sector of the circulatory system.

Arterioles↗