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Biomedical subjects

C F Terrence

Publications and source records attributed to C F Terrence.

5 recordsLinked to original sources

Hearing loss in carcinomatous meningitis.

Although the syndrome of carcinomatous meningitis presenting as multiple cranial neuropathies is well known, hearing loss as a presenting complaint has not been previously stressed. Five cases of carcinomatous meningitis beginning as hearing loss are presented and the clinical and laboratory features discussed. A thorough review of the literature summarizes the pathology, pathogenesis and recommended modes of therapy of this disease and the importance of early diagnosis and treatment is stressed.

Arachnoid

Computed tomography for Huntington's disease.

CT scans of twelve patients with Huntington's disease were compared with a large series of normal and abnormal scans. The frontal horn/bicaudate ratio in the Huntington's disease group was found to be much smaller than and statistically different from the normal or abnormal CT scan groups. The CT scan appears to be a useful adjunct in the evaluation of patients with suspected Huntington's disease.

Adult

Myotonic dystrophy and multiple sclerosis.

A 48-year-old man with myotonic dystrophy did well until the age of 37, when he developed the first of many remissions and exacerbations of multiple sclerosis. The only serum value done while the patient was infection free, revealed serum hypogammaglobulinemia. Three determinations of the relative concentration of gama globulin in the cerebrospinal fluid over 11 years, yielded markedly elevated levels. Previous work on the immunological abnormalities in both disease entities is discussed. This is the only published case in which these two diseases were manifested in the same patient.

Humans

Unexpected, unexplained death in epileptic patients.

Thirty-seven cases of unexpected, unexplained death in epileptic patients were recorded by the Allegheny County Coroner's Office during the years 1969 through 1973. In no case was there anatomic or chemical evidence at autopsy sufficient to explain death. All patients had a duration of epilepsy greater than a year. All but two had less than one seizure per month. Blood levels of anticonvulsants at autopsy revealed only three patients with therapeutic levels of the drugs. Almost 50 percent of the cases studied had no demonstrable anticonvulsant. It is suggested that inadequate levels of anticonvulsant drugs are a significant factor associated with unexpected, unexplained death in epileptic patients.

Adolescent