Some endocrine effects of the pineal gland and melatonin with special reference to reproduction.
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Animals↗
Biomedical subjects
C F de Gaetani
Publications and source records attributed to C F de Gaetani.
Ovulation induced by LH-RH in rats made anovulatory by various experimental procedures.
The injection of LH-RH induced ovulation in constant estrous rats (CEA), made anovulatory either by frontal hypothalamic deafferentation (FHD), or by exposure to continuous light (CL), or by neonatal androgenization (NA) with 0.500 mg testosterone propionate (NA500). Rats neonatally treated with 1.250 mg testosterone (NA1250) were almost unable to ovulate. 100% of FHD-CEA rats ovulated in response to 10 ng LH-RH, which is 1/3 of the lowest dose able to determine 100% of full ovulation in control proestrous rats. NA500-CEA rats, on the other hand, ovulated in response to doses comparable to those effective in the controls, whereas in CL-CEA rats the doses required for full ovulation were 2-3 times higher than in the controls. The results of these experiments demonstrate that the pituitary glands of CEA rats respond to the stimulation by the specific hypothalamic releasing factor. The pituitary response, however, appears enhanced in FHD-CEA rats and markedly depressed in CL-CEA animals.
Animals↗
Effect of pinealectomy and of bilateral cervical ganglionectomy on serum LH levels in constant estrous-anovulatory rats.
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Animals↗
Atypical hyperplasia of the prostate. A pitfall in the cytologic diagnosis of carcinoma.
The cytomorphologic features of atypical hyperplasia were studied in fine-needle aspiration biopsies of the prostate. Atypical hyperplasia material was found in 31 cases. The most usual and distinctive cytologic features of atypical hyperplasia were clustering of poorly-differentiated epithelial cells with acinic pattern and fairly regular nuclei. Another relevant feature was the lack of cytoplasmic fluorescence after acridine orange staining. These features make possible the diagnosis of atypical hyperplasia and the distinction from poorly-differentiated carcinoma. The recognition of atypical hyperplasia cells in fine-needle aspiration biopsies of the prostate is important in the avoidance of cytodiagnostic errors.
Acridines↗