Biomedical subjects

C Fady

Publications and source records attributed to C Fady.

22 records · Page 2Linked to original sources

PubMed1987

Lack of effect of a high polyunsaturated fat diet on the growth of transplantable colon tumors and on the cytolytic activity of macrophages in rats.

The effect of a high dietary level of polyunsaturated fat was tested on the growth of three different colon cancer cell lines injected subcutaneously into syngeneic rats. This effect was also tested on the in vitro cytolytic activity of resident peritoneal macrophages, natural or endotoxin and/or indomethacin-modulated. A 12% corn oil dietary supplement had no effect in any of the cases tested.

Animals↗

PubMed1986

[In vitro tumoricidal activity of peritoneal macrophages and splenic lymphocytes of rats under diet with or without fish].

Rats were fed with or without a diet supplemented with fish meal over a 4-week period. The moderate fish fatty acids intake had no influence on the tumoricidal activity of peritoneal and splenic lymphocytes.

Animals↗

PubMedDate not supplied

Mechanism of the cytostasis mediated by blood unstimulated neutrophils on syngeneic rat colon cancer cells.

Non-activated polymorphonuclear neutrophils (PMNs) isolated from the blood of non-stimulated rats were spontaneously and selectively cytostatic in vitro against a syngeneic colon cancer cell line. In this experimental model, the mechanism of PMN-mediated cytostasis did not depend on oxidative metabolites, but involved soluble factor(s), possibly granule proteases.

Animals↗

PubMedDate not supplied

In vivo and in vitro effects of fish-containing diets on colon tumour cells in rats.

Polyunsaturated n-3 fatty acids, abundant in sea fish, can inhibit the growth of chemoinduced or transplanted mammary tumours in the rat. Since mammary and colonic cancers have both been linked to a high fat consumption, we studied the effect of 2 diets moderately (7% fish meal) or strongly (9% fish oil) enriched in fish fatty acids on the growth of colon cancer cells subcutaneously inoculated into syngeneic rats. The diets had no effect on the in vivo tumor growth and on the in vitro tumouricidal activity of peritoneal macrophages or splenic lymphocytes.

Animals↗