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Biomedical subjects

C Faguer

Publications and source records attributed to C Faguer.

At least 19 recordsLinked to original sources
PubMed1996

[Acardiac fetus].

Acardiac fetus is a rare lethal fetopathy usually encountered in monozygous pregnancies. Ultrasound prenatal diagnosis has enabled an increasing number of observations and raised the need for an adequate therapeutic approach since the spontaneous prognosis for the healthy twin is unfavorable in half of the cases. An acardiac fetus was identified at 12 weeks gestation in a 36-year-old woman. Growth of the healthy fetus was carefully monitored and progressed normally to delivery by cesarean section of a 2.900 kg boy at 36 weeks. At delivery, the acardiac fetus was found to be totally free of any attachment, floating in the remaining fluids. Pathology examination showed a 16 g macerated fetus with a cephalic extremity, a ventral pedicle and a syrenomelic caudal extremity. The caryotype was not significative. Acardiac fetus occurs in less than 1% of multiple pregnancies and can develop in single pregnancies. Twin reversed arterial perfusion has been recognized as necessary for development of the perfused fetus. Genetic and immunologic theories have been proposed to explain the pathogenesis which remains unknown. Clinical management depends on the spontaneous development of the acardiac fetus and the deleterious consequences for the healthy twin resulting from heart failure, anasarca or prematurity. Medical management with digoxin, or selective extraction by hysterotomy may improve prognosis but results have been variable. Echoguided umbilical cord ligation has also been proposed to improve maternal mortality. Therapeutic abstention is no longer indicated at prenatal diagnosis of an acardiac fetus and a healthy twin despite the risk of invasive treatment.

Adult↗
PubMed1994

[Study and significance of ferritin levels in 104 women using intrauterine devices].

OBJECTIVE: To study the ferritin level in women using an intrauterine device. METHODS: 104 women were enrolled before and during use of the intrauterine device. The subjects were divided into four groups according to whether or not they had used oral contraception previously. RESULTS: There was a significant decrease in ferritin level, particularly in women who had not used contraception previously (Student's test). CONCLUSION: Ferritin assay is a better test for measuring the effect of an intrauterine device on iron depletion than blood cell count or haemoglobin level.

Adult↗
PubMed1993

[The intrauterine device: are there still contraindications? A study on 300 Gyne-T 380 users (1987-1992)].

Uterine malformations, history of infection and nulliparity are the classical contraindications to insertion of an IUD, while uterine scars and malpositions constitute relative contraindications. In a context of a marked reduction in the number of IUD users, the author reviews this method based on his personal experience of 300 cases. The indications for this type of contraception can be safely extended, as it constitutes a valuable alternative to other methods.

Adult↗
PubMed1988

[Uterine rupture due to placenta accreta at 22 weeks' pregnancy. Apropos of a case].

Although early rupture of the uterus is rare, that does not mean that it should not be considered. The case reported here was of a patient in her third pregnancy who suddenly presented with internal haemorrhage requiring immediate laparotomy at the 22nd week of pregnancy. When a broad rupture at the fundus was discovered total hysterectomy had to be carried out. Immediately afterwards the patient collapsed and this required a further operation which showed that one of the cervico-vaginal pedicles had slipped away from its ligature. After this, recovery was uncomplicated. Histological examination made it clear that the cause of the rupture was a placenta increta which had grown on the fundus which itself contained a fibroid. Early ruptures of the uterus are very rare and usually occur in a uterus that has been weakened by an anterior scar, or an abnormal development during the pregnancy or a malformation of the uterus. It is rare for placenta increta to be the cause. We have reviewed the clinical and histological material. Hysterectomy is carried out in order to ensure haemostasis and the procedure is discussed.

Adult↗
PubMed1984

[Maternal mortality in 1983. A propos of our experiences at Saint-Antoine].

The maternal mortality rate is approximately 3 per 10,000 in France. This figure is not insignificant and merits further consideration. Mortality has decreased at intervals over the course of history, depending upon certain factors such as maternal age, ethnic origin, the country in which the delivery takes place, economic conditions, the delivery setting, etc. The statistic of 1 death per 10,000 live births has been obtained by several countries and is difficult to ameliorate. Certain sudden, unexpected deaths will continue to occur despite adequate care and irrespective of whether or not they are due to a prior disease process. By studying the frequency and etiologies of these deaths, a recurring set of circumstances can often be identified, the caesarian section being of foremost importance. The mortality rate, then, appears to be a good indication of the quality of care delivered by a country or by an obstetrical department.

Adult↗
PubMed1983

[The epidemiological study of endometrial adenocarcinoma. From 74 cases seen at the Saint-Antoine Maternity Hospital].

The epidemiologic study of 74 invasive endometrial adenocarcinomas seen over five years confirms the following well-known risk factors: early menarche, disorders of menstruation, hypofertility, and late menopause. Obesity, a positive family history and the presence of another cancer are common findings. Hormone dependent endometrial cancer provides a valuable opportunity for studying hormone and cell receptor concentrations. Hormone dependency has a practical bearing on certain preventive measures and perhaps on a new therapeutic approach to this type of cancer.

Adenocarcinoma↗
PubMed1983

[Myomectomy in nonpregnant women. Indications. Technics. Apropos of 70 cases at the Saint-Antoine's Maternity Hospital].

Seventy cases of myomectomy performed over 5 years (1977 to 1982) in the department of Gynecology & Obstetrics of the St Antoine Hospital in Paris are analyzed. During the same period, 465 patients underwent hysterectomy for leiomyoma. A brief review shows that myomectomy is not the best surgical treatment of uterine leiomyoma because of its complications. Hemorrhagy, pelvic pain and infertility remain the principle modes of discovery of uterine leiomyoma in operated patients, whose median age is fairly low. Hysterosalpingography is still the main procedure for the investigation and diagnosis of leiomyoma. However, indications of echotomography have been extended with an increase in the frequency of diagnosis of leiomyoma due to a better semiology. Primary leiomyoma section followed by excision appears preferable to conventional enucleation, which is frequently hemorrhagic and blind. In determining the indications of myomectomy, certain factors must be borne in mind: age, parity, type and insertion of leiomyoma, gynecologic history and psychological status. Good postoperative results explain the recent favor of myomectomy as the conservative surgical treatment of leiomyoma; surgical abstention, however, remains the best decision in most cases.

Adult↗
PubMed1983

[Borderline ovarian tumors: an epidemiologic, diagnostic, prognostic and therapeutic study. Apropos of 20 cases reported at the Saint-Antoine Maternity Hospital].

Twenty cases of borderline ovarian tumors were seen in the Department of Gynecology and Obstetrics at the St. Antoine Hospital over 5 years. The epidemiological study of these 20 tumors, relative to 47 invasive ovarian carcinomas seen over the same period, shows that hypofertility is more prevalent and that patients are younger. Diagnosis rests mainly on the histological examination of the operative specimen. The overall prognosis is good but recurrences, which may be delayed, are possible. These patients, who are often young, may be managed conservatively, at the cost of prolonged follow-up, including cytologic and coelioscopic examinations.

Adult↗
PubMed1983

[Comparative study of 15 borderline tumors and 31 cancers of the ovaries. Epidemiologic, diagnostic and therapeutic aspects].

46 epithelial tumours of the ovary were seen over a period of 5 years. These tumours could be subdivided into 15 borderline tumours and 31 invasive cancers. An epidemiological study did not make it possible to find special factors in relationship to these two types. Studying the circumstances under which diagnoses were made demonstrated the value of considering: pain, ultrasound pictures and cytology from the Pouch of Douglas. It is essential to carry out laparotomy in every case of an organic tumour of the ovary. It is only by histological examination that it is possible to tell whether a tumour is borderline of invasive. A protocol for carrying out treatment is suggested. The results confirm the excellent prognosis for borderline tumours and the seriousness of other epithelial cancers of the ovary.

Adolescent↗
PubMed1982

[External pelvic endometriosis: diagnostic study. Our experience in the maternity department of Saint-Antoine Hospital. A propos of 130 cases].

The circumstances leading to the diagnosis of pelvic endometriosis (adenomyosis excluded) were studied in 130 patients. From the epidemiological data yielded by these cases, the profile of women susceptible to this disease is delineated. Hysterosalpingography is the key to the diagnosis of endometriosis in most instances; however, coelioscopy and/or laparotomy are required to establish the diagnosis, as well as for staging the disease which is important for the choice of therapy.

Adult↗