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C Fee
Publications and source records attributed to C Fee.
Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity.
Beta-adrenergic blockade with intrinsic sympathomimetic activity (ISA) causes less depression of resting and submaximal heart rate (HR) than non-ISA beta-blockers. The effects of these drugs on exercise haemodynamics have not been well studied. We evaluated effects of pindolol, propranolol and placebo during rest and steady-state exercise on cardiac output, oxygen consumption, calf blood flow, HR and blood pressure in 18 healthy subjects. Pindolol 5 mg and propranolol 80 mg given twice daily, reduced maximal exercise HR by 50 and 52 beats.min-1 respectively, confirming similarity of beta 1-blockade. Resting cardiac output was unchanged in all three groups after one week of therapy. Cardiac output, measured during steady-state exercise decreased in the propranolol group (18.3 vs 15.6 l.min-1) with no significant changes in pindolol (15.7 vs 16.01.min-1) or placebo (18.6 vs 17.3 l.min-1). The rise in cardiac output, from rest to exercise, was similarly attenuated by propranolol but not by pindolol or placebo. Exercise stroke volume increased 12% on pindolol (123-140 cc) and decreased 7% on propranolol (143-133 cc). Neither drug had a detrimental effect on exercise calf blood flow compared to placebo. Thus, unlike propranolol, pindolol with ISA, maintains a normal cardiac output during submaximal exercise.
Adult↗
Effect of aerobic conditioning on the peripheral circulation during chronic beta-adrenergic blockade.
The relation of peripheral circulatory adjustments to exercise training during long-term beta-adrenergic blockade has not been investigated. In 12 healthy men aged 22 to 34 years, blood flow in the calf was evaluated with submaximal exercise before and after a 6 week aerobic conditioning program. During conditioning, six subjects received no drug and six received propranolol, 80 to 120 mg/day in divided doses. Treated and control subjects were studied on entry and at the conclusion of a conditioning program, 72 hours after drug withdrawal in subjects given propranolol. The training was intensive and equivalent in both groups. Control subjects increased maximal oxygen uptake from 47.5 +/- 1.1 to 51.4 +/- 0.4 ml/kg per min (p less than 0.05), whereas those on propranolol did not improve. Immediately after exercise, blood flow in the calf was measured with strain gauge plethysmography after 3 minutes of supine exertion on a cycle ergometer. In control subjects, flow decreased from 15.7 +/- 1.6 to 14.0 +/- 1.4 ml/100 ml per min at 300 kg-m/min of exertion (p less than 0.05) and from 26.5 +/- 3.8 to 21.8 +/- 2.3 ml/100 ml per min at 700 kg-m/min (p less than 0.05). Vascular resistance was unchanged in these subjects at 300 kg-m/min (6.1 +/- 0.8 to 6.7 +/- 1.0 pru) (p = NS), but increased at 700 kg-m/min (4.2 +/- 0.8 to 4.8 +/- 0.7 pru) (p less than 0.05). In subjects given propranolol, no change in flow or resistance occurred after training at either work load.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗