PubMed Health⌕ Search

Biomedical subjects

C Fei

Publications and source records attributed to C Fei.

9 recordsLinked to original sources
PubMed2004

Adsorption and recovery of Cu (II) with polysulphone microcapsules containing chitosan gel.

Polysulphone (PSF) microcapsules (PSF-CTS) containing chitosan gel with higher mechanical stability and anti-biodegradability were prepared using a novel surface coating method. The thickness and microstructures of the polysulphone coating layer were analysed by SEM. The experiments to examine the mechanical improvement of the encapsulated gel beads were carried out. The adsorption for Cu2+ and regeneration properties of unencapsulated and encapsulated gel beads were also tested. The results showed that the mechanical strength of the encapsulated gel beads was significantly enhanced. However, this improvement led to a decrease of the adsorption kinetics due to the increase of the mass transfer resistance. The potentially available methods are suggested to reduce mass transport resistance through the PSF coating layer.

Adsorption↗
PubMed2001

[A comparative study on wound healing treated by different doses of bovine basic fibroblast growth factor (bFGF)].

OBJECTIVE: To explore the optimal dosage and method of bFGF application on surgical wound for accelerating its healing. METHODS: Laceration wounds on the extremities of 73 patients were served as the target. The wounds were applied with three different doses of bFGF (75 Au/cm(2), 150 Au/cm(2), 300 Au/cm(2)) and with three application methods, i.e. once a day, three times a day and once a day with moistening. Normal saline with 0.5% metronidazol was employed as control agents. The wound healing time in every groups was recorded in days and compared with each other. RESULTS: When compared to each other, the wound healing time (day) was much shorter (P < 0.05) with bFGF application in dose of 75 similar 300 Au/cm(2). There were also obvious differences in wound healing time among groups treated with the same dose but with different methods (P < 0.01). In addition, three times a day and once a day with moistening of bFGF application could further shorten the wound healing time. CONCLUSION: Compared to the dosage of the agent, the frequency and method of bFGF application seemed more important for its optimal effects. In view of the convenience, feasibility and economy, once a day with moistening was recommended for clinical application.

Adolescent↗
PubMed1998

Synthesis and structure-activity relationships of 2-pyrazinylcarboxamidobenzoates and beta-ionylideneacetamidobenzoates with retinoidal activity.

The structure-activity relationships of two series of novel retinoids (2-pyrazinylcarboxamidobenzoates and beta-ionylideneacetamidobenzoates) have been investigated by evaluating their ability to induce differentiation in both human promyelocytic leukemia (HL60) cells and mouse embryonal carcinoma (P19) cells. The most active compound (ED50 = 8.3 x 10(-9) M) of the 2-pyrazinylcarboxamidobenzoates is 4-[2-(5,6,7,8-tetrahydro-5,5,8, 8-tetramethylquinoxalyl)carboxamido]benzoic acid (9u), while the most active analogue of the beta-ionylideneacetamidobenzoates is 4-[3-methyl-5-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-(2E, 4E)-pentadienamido]benzoic acid (10a, ED50 = 3.2 x 10(-8) M). Our studies identify an absolute requirement for the carboxylic acid moiety on the aromatic ring to be para relative to the amide linkage for activity. Benzoate substitutions in the ortho position relative to the terminal carboxylate (9d,k,r) are well-tolerated; however, a methoxy substituent meta relative to the terminal carboxylate gives rise to only weakly active analogues (9x). Conformational studies (NMR, X-ray crystallography) of the 2-pyrazinylcarboxamidobenzoates indicate that the preferred conformation exhibits a trans-amide bond and an internal hydrogen bond between the quinoxaline N1 and HN amide which locks the torsional angle between C2 and CO in the s-trans conformation. N-Methylation (9y) results in loss of activity. Studies indicate that there is now a cis-amide bond present which redirects the carboxylate toward the pharmacophoric gem-dimethyl groups. The distance between the gem-dimethyl group and the terminal carboxylate appears to be too short to activate the retinoid receptor. N-Methylation in the beta-ionylideneacetamidobenzoate series (10c) also results in the formation of a cis-amide bond and loss of activity.

Animals↗
PubMed1996

[Surgical treatment of ventricular septal defect in 2,169 patients].

From June 1964 to June 1993, 2,169 patients with ventricular septal defect (VSD) including perimembranous VSD (1520), subpulmonary (VSD), VSD beneath tricuspid septal leaflet in 249 patients:muscular VSD(5), left ventricle-right artrium canal VSD(7), multiple VSD(8) underwent surgical treatment. Of 271 patients associated with serious pulmonary hypertension, 51 patients had pulmonary tissue biopsy during operation and pulmonary vessels were graded. Indications for the operation of VSD, prevention of complication and management of associated lesions were discussed.

Adolescent↗
PubMed1996

[Valve replacement in children].

We report 27 children aged 2-14 years underwent valve replacement. Twelve patients underwent mitral valve replacement, 11 tricuspid valve replacement, and 4 aortic valve replacement. Of them, 16(59.3%) were associated with cardiac malformation, 23 were in NYHA functional class III and IV in preoperation. 13 patients required additional procedures. There were 3 hospital deaths (11.1%), 4 late deaths (16.6%), and 2 reoperation. Our experiment suggested that the greater type of mechanical valve be essential for valve replacement in children, but suture technique be modified for the children with small valvular ring. After replacement of mechanical valve, low concentration anticoagulation therapy is considered as a safe and reliable method.

Adolescent↗
PubMed1994

[Heparin-induced thrombocytopenia: review of the literature and description of 2 clinical cases].

We present a literary review regarding heparin-induced thrombocytopenia and we report two cases. The first case regards a female patient with a suspect pulmonary embolism and deep vein thrombosis. Low platelet count was observed already during sub-cutaneous heparin therapy but was aggravated by subsequent intra-venous treatment. The second patient developed thrombocytopenia only after intra-venous heparin infusion while previous sub-cutaneous heparin prophylaxis had not caused low platelet count. In both patients platelet counts normalized rapidly only a few hours after withdrawal of heparin treatment. We therefore point out the importance of the correct monitoring of platelet counts for a timely detection and prevention of heparin-induced thrombocytopenia, and possible consequent paradoxical thrombosis.

Aged↗
PubMed1992

[Analysis of 65 cases of abruptio placenta].

From Jan 1, 1971 to Dec 12, 1990, 65 cases of abruptio placenta were admitted to our hospital. The incidence was 0.19%. Among them, thirty were complicated by pregnancy induced hypertension (46.2%). The perinatal fetal mortality was 19.7%; perinatal death occurred mostly in the premature group. All babies survived except two abnormalities. Cesarean section rate was 32.3%. All postpartum hemorrhage 29.2%. Couvelaire uterus 6.2%, were cured by conservative treatment. There was neither stillbirth nor newborn death in the thirty three cases treated expectant, but a newborn asphyxia rate of 6.1% and a cesarean section rate of 15.1%. Analysis showed that abruptio placentae should be suspected in cases with abnormal fetal heart rate of unknown cause accompanying signs of labor, premature labor of unknown cause, uterine tongue, ultrasonically visualized liquid from dark area behind the placenta, besides classical signs of abdominal pain and vaginal bleeding. Expectant treatment is appropriate if gestational age is small and no acute symptoms exists so as to minimize the perinatal mortality and cesarean section rate.

Abruptio Placentae↗
PubMed1989

The re-expression of two myosin heavy chains in regenerated rat muscle spindles.

The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for enzymes that delineated fiber type, sensory endings and motor endings. MF30 and ALD58, two antibodies which react only to intrafusal fibers in normal rat muscle, were reacted against sections of nerve-intact muscle grafts. Data were compared to that from muscles of normal rats. Encapsulated fibers devoid of sensory innervation and some extrafusal fibers in muscle grafts had a weak to moderate reaction to MF30, but no reaction to ALD58. Regenerated, encapsulated fibers with sensory innervation bound both MF30 and ALD58. These data indicate that afferents which reinnervate regenerated spindles retain the capacity to induce expression of spindle-specific myosin isoforms in rats.

Animals↗