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Biomedical subjects

C Fiehring

Publications and source records attributed to C Fiehring.

At least 19 recordsLinked to original sources
PubMed1987

[Gastrointestinal microecology from the viewpoint of the pediatrician].

Under unfavourable circumstances a weakened resistance status within the newborn period may lead to acute or chronic diseases later on, too. In the early childhood, coli-infections connected to enterotoxin release are the most frequent reason for bacterial diarrhoeas. For some time cases of colitis and salmonellosis are increasing, whereas such of campylobacter enteritis became more seldom. Cases of shigellosis are decreasing. Also Yersinia infections and cases of mycosis can be found rather frequently. The knowledge about rotavirus infection led to a better understanding of many a disease. Anomalies of the intestinal flora should be determined more carefully in order to recognize and to attend acute and chronic diseases as soon as possible. Breast-feeding remains the best prophylaxis in early infancy.

Child↗
PubMed1987

Rotavirus persistence in malabsorption syndrome: virus assessment by immunofluorescence in small intestine biopsies in relation to antibody titres.

Results of quantitative immunofluorescence (IF) in small intestine biopsies and the serum antibody titres as detected by indirect Rotalex test in rotavirus infections were compared using regression and correlation analysis. Based on the significance of the statistically established correlation (r = 0.76; n = 30) between immunohistological identification of rotavirus antigen and determination of serum antibody levels, the indirect Rotalex test may be applied as a diagnostic tool to avoid biopsies in productive rotavirus persistence.

Adolescent↗
PubMed1984

[Detection of rotavirus in patients with malabsorption].

Investigations were carried out to evaluate frequency and pathogenic effects of rotaviruses. For this purpose 53 biopsy specimens were taken from the jejunum, especially of children at an age up to 15. Because of their malabsorption the patients have undergone a special gastroenterological treatment for years or they only recently began with it, being suspected of suffering from this disease. Rotavirus antigen was indicated in 43% of the cases by means of immunohistology, at which only less part of the patients (sucklings and infants) showed a corresponding symptomatology. The greater part of the patients was without findings in the relevant sense.

Antigens, Viral↗
PubMed1984

[Rotavirus and malabsorption. Immunofluorescence microscopy studies of small intestine specimens].

Only 20% of the total of diarrheas in childhood are caused by bacteria . Compared to it, very often the causes for such diseases are viruses, especially rotavirus. The virus - localisation is known to be in enterocytes of the duodenal or jejunal mucosa. So it is probable that a destruction of villous structure linked with diminishing of enzyme activities-especially of lactase--can occur. 53 mucosa specimens were investigated from children by means of fluorescence microscopy. Cryo-cut-slices (8-10 mu) were fixed in acetone and marked with self-prepared rotavirus-hyperimmuneserum (against SA11-virus) and examined using the microscope Fluoval. The distribution of fluorescence along the villi or flat surface was semiquantitatively evaluated. All the investigated children - aged 1-15 years - had been suspected for malabsorption. In 23 of them rotavirus antigen was detected and partly a low activity of disaccharidases, especially of lactase, but also there were simultaneously 7 cases of confirmed coeliac disease in this group. So we conclude: In some patients the rotavirus infection is a complication of malabsorption syndromes; or in other cases it is an asymptomatic accidental finding in the small intestine mucosa.

Adolescent↗
PubMed1979

[Development of ossification in children with chronic digestive insufficiency (author's transl)].

In 84 children suffering from chronic insufficiency of digestion, ossification of both hands was observed by means of fluoroscopic controls for several years. In 48 of 71 patients there was a retarded ossification; in 23 it was normal, or respectively more advanced. 18 boys and girls succeeded in making up for there retardation by means of consequent diet so that it might be regarded as a "spurt of growth". But in 10 of them retardation was constant, and in 14 children it increased. The causes of insufficient improvement were: late diagnosis and therapy, failures of diet, but also additional diseases--different from digestive insufficiency--, and long-term use of corticosteroides. In 30 of 84 children ossification was always normal or advanced. They had received early and consequent diet for years. Only in few cases, slight or moderate diseases were diagnosed. Development of ossification was parallel to body height, but not to weight gain.

Age Factors↗
PubMed1979

[Growth development of children suffering from chronic insufficiency of digestion under dietary therapy for several years (author's transl)].

83 children suffering from malabsorption and disorders of metabolism were investigated with regard to body growth and weight gain. Though at first the increase of weight in comparison to body height was more rapid, the norm was obtained by the time the children were starting school. The period of retardation depended on the severity of disease and the diet being strictly kept to. It is most important that the circumference of the head was normal, though the other proportions of the body were too small for the age. These findings are parallel with normal intellectual development.

Adolescent↗
PubMed1977

[Mental development of children suffering from chronic insufficiency of digestion under dietary therapy for several years].

73 children suffering from malabsorption, galactosaemia, and fructose intolerance had been treated for many years. They were investigated psychologically in regard of their mental development. The nutritional condition was very bad before and in the first time of therapy, nevertheless a normal intelligence and an inconspicuous social behaviour was founded. The considerable retardation of the bodily and intellectual development was not sufficiently compensated in the preschool-age. But there is a better arrangement during school-age.

Adolescent↗
PubMed1976

[L-alanyl-L-proline-dipeptidase and glycyl-L-valine-depeptidase in malabsorption syndrome].

On the basis of comparative determinations of the activities of dipeptidases and disaccharidases of the mucous membrane of the small intestine (proximal jejunum) clear correspondences between the morphological findings and the biochemical parameters were the result. L-alanyl-L-prolin-dipeptidase and glycyl-L-valin-dipeptidase as well as lactase, saccharase, maltase and trehalase were determined in altogether 45 children with various malabsorption syndromes of different age in different stages of disease. Diminutions of the activity of the dipeptidases were to be proved analogously to maltase, saccharase and lactase, too, in most cases of subtotal or total villous atrophy. From the results conclusions may be derived to the restricted ability of protein absorption in chronic disease of the small intestine.

Biopsy↗