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Biomedical subjects

C Fillastre

Publications and source records attributed to C Fillastre.

At least 19 recordsLinked to original sources
PubMed1989

[Tetravalent diphtheria, tetanus, pertussis and inactivated poliomyelitis vaccine].

Two hundred forty-nine infants were immunized after being randomly allocated to the classical Tetracoq vaccine or to inactivated poliomyelitis vaccines prepared on monkey kidney cells or on Vero-type continuous cell lines either mixed with DPT or placed in a 2-compartment syringe separating (by-pass) the polio vaccine from the DPT. The 3 preparations were well tolerated and led to a good immune response: the first after 3 injections, the second and third after the second injection.

Clinical Protocols↗
PubMed1988

The stability and immunogenicity of a dispersed-grown freeze-dried Pasteur BCG vaccine.

The level of antituberculous immunity seems to be related to the number of memory T cells induced. This may vary as a function of the multiplication and persistence of BCG in host tissues. The most important requirements for a BCG vaccine are, therefore, the immunogenicity of the strain, the high proportion of live to dead bacilli, and adequate dispersion and low levels of soluble antigens. The surface-grown Pasteur BCG vaccine contains a very high proportion of bacilli killed by ball-milling and freeze-drying. It also contains clumps and soluble antigens, all factors influencing cell-mediated immune processes and viability control. Therefore, several batches of vaccine were prepared on an industrial scale using one of the most immunogenic strains (French 1173 P2) and grown as dispersed bacilli by a modified cell type culture method. This method provided fully viable, well-dispersed vaccines which have a viability and heat stability superior to that of the classical surface-grown BCG. The immunogenicity was checked by multiplication and persistence in mouse organs and the skin reactivity and tuberculin hypersensitivity in guinea-pigs showed results comparable to those obtained with classical vaccine. Small-scale tests in children showed superior immunogenicity of the dispersed as opposed to the classical vaccine and there was no suppurative adenitis.

Animals↗
PubMed1988

[20 years' use of the diphtheria-pertussis-tetanus vaccine].

Between 1966 and 1982, a triple DPT vaccine was studied in France in 1,871 infants between the ages of 3 and 5 months. The study covered tolerance and serological efficacy of two immunization schedules using 2 or 3 initial injections. Computerized analysis of the 877 complete files showed satisfactory tolerance of this association and the serological efficacy of 2 initial doses of tetanus and diphtheria vaccines. Pertussis immunization is only effective after 3 injections. The presence of maternal antibodies when the first injection is given only decreases the immune response of diphtheria vaccine.

Antibodies, Viral↗
PubMed1987

[Vaccination and malnutrition].

Although a depressed cellular immunity may be present in proteino-energetic malnutrition, humoral immunity is usually normal. Except for vaccines acting through a stimulation of cellular immunity like BCG, infants and children with malnutrition show a normal immune response to immunisations without a majoration of the side-effects. Consequently there is no contra-indication to immunisations in malnourished infants and children. Early immunisation before the age of one should be encouraged in countries where malnutrition in children is frequent.

Antibody Formation↗
PubMed1981

Clinical trial of concentrated inactivated polio vaccine in a simplified immunization program.

The aims of the trial were: 1) to verify the effectiveness of injectable polio vaccine (inactivated) combined with concentrated diphtheria and tetanus toxoid, in one or two injections given at an interval of 6 months; 2) to compare the killed polio vaccine with the oral vaccine which is recommended in the Ivory Coast program: 4 doses in 15 months. The effectiveness of the immunizations is judged by the serum antibody levels 8 to 12 weeks following immunization. The comparative study of 2 inactivated polio vaccines A and C with live oral vaccine showed the superiority of inactivated vaccine, which resulted in good seroconversion after a single dose. The increase in the serologic response is proportional to the antigenic mass since it appears that the concentration of vaccine C is double that of A.

Clinical Trials as Topic↗
PubMed1978

Killed poliovirus antigen titration in humans.

To establish the antigen content of a killed poliovirus vaccine sufficiently potent to induce immunity with one or two doses and to establish a reference standard vaccine which has been tested under field conditions, a titration was carried out in infants to determine the amount of each of the three antigenic types of poliovirus vaccine required to induce seroconversion with a single dose. It has been observed that over a critical range of antigen concentration there is an essentially linear relationship between antibody response and quantity of antigen administered. More than 90 percent of the groups studied had detectable antibody after receiving single injections of 80, 8 and 64 D-antigen units of Types I, II and III, respectively. Four-fold less antigen for each of the three types was less effective. The implications of these findings for an efficient immunization procedure are discussed.

Antibodies, Viral↗
PubMed1970

The use of jet-injectors in BCG vaccination.

In mass vaccination programmes, the jet-injection of vaccine may have considerable operational advantages over the classical techniques. The technical performance of two models of jet-injector, the Dermo-Jet and the Ped-O-Jet, in BCG vaccination was assessed in a number of studies which are reviewed by the authors. It is shown that the jet-injectors do not administer the full dose for which they are calibrated and that the size of the vaccination lesion varies more than after vaccination by syringe.By increasing the dosage considerably, the results of vaccination by jet-injection may be improved to a certain extent but the risk of unpleasant reactions is also increased.

BCG Vaccine↗