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Biomedical subjects

C Finch

Publications and source records attributed to C Finch.

7 recordsLinked to original sources
PubMed1992

Endobronchial closure of a postpneumonectomy bronchopleural fistula.

Successful permanent endobronchial closure of a serious postpneumonectomy bronchopleural fistula is reported in a patient with a delayed diagnosis of Mycobacterium fortuitum-cheloni infection. Increasing experience, improved plugging agents, and a review of the literature suggest that in selected patients, this procedure can avoid complex repeat operations and reverse life-threatening situations. Although atypical mycobacterial infections occur with infrequency, they are difficult to treat and may lead, as in this patient, to a misdiagnosis. Operations on granulomatous tissues are prone to heal poorly, thus inviting tissue breakdown and chronic fistulas.

Bronchial Fistula↗
PubMed1992

Thyroid function in a formerly goitrous community on Karkar Island, Papua New Guinea.

During a survey of noncommunicable disease conducted on Karkar Island, Madang Province in 1986, measures of thyroid function were examined in adult residents of a formerly goitrous village (Gamog) and a neighbouring community (Marup) with no history of iodine deficiency or endemic goitre. In Gamog, almost 20% of males and almost 30% of females had palpable goitre (maximum prevalence at ages 35-54 years) but visible goitres were not encountered. However, thyroid function tests were generally similar in the two groups, suggesting that iodine deficiency is no longer an appreciable problem for adults in Gamog. The persistence of palpable goitre in this village is therefore likely to be a residual effect of previous iodine deficiency. Correction of the iodine deficiency in the Gamog community began with the program of iodized oil injections, which was undertaken in the 1970s. The current lack of iodine deficiency is probably due in the main to dietary change associated with the introduction of the cash economy. This effect may have occurred in many formerly goitrous communities in Papua New Guinea in recent years, although persistence of iodine deficiency in some parts of the country should not be discounted.

Adult↗
PubMed1991

Glucose tolerance in Papua New Guinea: comparison of Austronesian and non-Austronesian communities of Karkar Island.

Epidemiological studies in Pacific populations have suggested a relationship between glucose tolerance and proportional Austronesian genetic admixture, with non-Austronesian Melanesians relatively free of glucose intolerance. However, a survey conducted in 1985 demonstrated the apparent emergence of glucose intolerance in a peri-urban non-Austronesian community, casting doubt on this hypothesis. In 1986 glucose tolerance was studied in three village communities on Karkar Island, Papua New Guinea. Two were of Austronesian and one was of non-Austronesian genetic ancestry. Prevalence of diabetes was low in all communities. However, prevalence of impaired glucose tolerance (IGT) was 7% in the more developed Austronesian community, as compared with 2% in the equivalent non-Austronesian group (p less than 0.05). Multiple regression analysis demonstrated not only a highly significant association between 2-h plasma glucose and insulin concentrations (p less than 0.001), but also that for a given value of plasma insulin, 2-h plasma glucose values were lower for non-Austronesian than for Austronesian subjects (males, p less than 0.05, females, p less than 0.01). However, average plasma insulin concentrations were relatively high in the non-Austronesian community, despite lower average plasma glucose concentrations.

Adult↗
PubMed1979

Catecholamine elevation in iron deficiency.

Iron-deficient rats have increased blood and urinary catecholamines regardless of whether anemia is or is not present. The catecholamine response in both iron-deficient and control animals is largely temperature dependent, showing little difference at the isothermic temperature of 30 degrees C but a two- to threefold increase in iron-deficient animals over controls at lower temperatures. The iron-deficient rat is unable to maintain body temperature at 4 degrees C and this is independent of anemia or of food intake. When animals are run on the treadmill for 4 h, body temperatures increase but the difference observed at 4 degrees C between iron-deficient and control animals persists. The underlying abnormality in temperature regulation and in catecholamine response disappeared after 6 days of iron therapy.

Animals↗
PubMed1978

Plasma radioiron kinetics in man: explanation for the effect of plasma iron concentration.

The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.

Adult↗