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Biomedical subjects

C Fiorio

Publications and source records attributed to C Fiorio.

9 recordsLinked to original sources
PubMed1986

[Serologic diagnosis of streptococcal diseases. Ulterior data on the comparison of 2 methods (streptozyme and antistreptolysin O].

Increasingly thorough analysis of the antigen structures of Group A beta-haemolytic streptococci has revealed the presence of antigen components with differentiated immune responses in relation to common streptococcal conditions. It is therefore extremely useful in laboratory practice to have a multiple antigen that reveals the immune response to a streptococcal infection so that we can study the serological behaviour of individual streptococcal pictures with their complications and sequelae. Research conducted to date indicates that the streptozyme test can explore the five main streptococcal isoenzymes both for rapid screening and for the quantification of the degree of antibody response. This is confirmed by the results obtained by numerous Authors over the past 15 years, results that demonstrate the high sensitivity of STZ (Streptozyme) at antibody level that single antibody reactions are apparently not capable of revealing. The polyvalent antigen represented by STZ seems to be the best tool for the demonstration of responses to the individual isoenzymes of the very numerous streptococcal strains in circulation (Group A, C and G beta-haemolytics). The possibility of using microtiter techniques for serum assays is also emphasised. These techniques have given repeatable results and are also easy to read.

Antibody Formation↗
PubMed1980

[Adenopathies in chronic myeloid leukemia (CML). Study of 161 cases].

161 cases of CML have been studied. Clinically significant adenopathies were present in 3,2% of the patients at the moment of diagnosis, and in the subsequent course they appeared in 7% of them. The behaviour of adenopathies showed to be unrelated to: --splenomegaly; --blastic metamorphosis in the peripheral blood or in the marrow (which they often preceded from 3 to 26 months); --hematological sensibility to cytostatic therapy; and furthermore they often acted as the most important clinical and therapeutic problem. From the cyto-histological point of view three features have been observed: 1) blastic metamorphosis in a lymphnode showing features of myeloid metaplasia; 2) blastic invasion in a lymphnode without any sign of myeloid metaplasia; 3) malignant lymphoma. Cytological examination of imprints and ultrastructural studies, besides the usual histological investigations, proved to be useful for the definition of the above mentioned features. In lymphomatous forms, together with the study of the cariotype and the research of the Ph' chromosome, the performance of immunocytological investigations is also necessary.

Adult↗
PubMed1980

[Chronic hepatitis caused by B virus (HBV)].

Following a short review of the viruses underlying viral hepatitis and those which, as a secondary factory in the clinical picture, may cause fleeting liver damge, the subdivision of chronic hepatitis conditions on histopathological bases is described. Particular attention is paid to pathogenesis, with a study of the elimination of B virus, correlated to particular histopathological types. A series of 27 PCH and 49 ACH cases is reported. Of special significance was the observation of 14 ACH out of 17 biopsied drug addicts. The therapeutic problem of chronic hepatitis is then tackled.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Lymphocytic and lymphocytoactive components in the etiopathogenic mechanisms of systemic lupus erythematosus. An analysis of the literature].

Lymphocyte populations play an important role in the mechanism of autoantibody induction, mainly of antinuclear ones, in such collagen diseases as S.L.E. Aetiology and pathogenesis of SLE are multifactorial: genetic predisposition, lupogenic factors (among them the hormonal ones) with direct and indirect action on B and T lymphocytes, conditioning the production of lymphocytotoxins and antibodies against blood cells. Subjects carrying the HLA DRW3 antigen have three to four times more probabilities to get a S.L.E. In the serum of SLE patients as well as in their relatives auto-or heterolymphocytotoxic antibodies are present, directed against the antigens of the HLA complex. There is evidence that antilymphocyte antibodies appear in patients with procainamide induced SLE, as well as anti-IgG - and antierythrocyte antibodies; this fact is due to the impairment of the immunologic regulation. Concerning the circulating immunocomplexes (CIC) in idiopathic S.L.E., it was observed that they increase in patients with active SLE, but there is no statistical evidence of a significant inverse proportional rate of these parameters. The role of CIC in SLE induction is bound with T lymphocyte subsets.

Animals↗