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Biomedical subjects

C Florent

Publications and source records attributed to C Florent.

88 records · Page 5Linked to original sources
PubMed1980

[Intestinal clearance of alpha 1 anti-trypsin: a simple technique for diagnosis of protein losing enteropathy (author's transl)].

Until recently, to diagnose exsudative enteropathy required the use of radio-isotopes and a stay of several days in hospital. Alpha-1-antitrypsin can now be used as endogenous plasma marker and assayed in the serum and faeces by a simple immunochemical method, thus measuring its intestinal clearance. Fifteen healthy subjects and 13 patients with organic digestive diseases were investigated by this method. The mean clearance values were inferior to 10 ml/24 h in the control group and significantly higher in the patients' group. Digestive protein loss can therefore be diagnosed by the new method, which offers the additional advantages of being reliable, easy, relatively inexpensive and applicable to out-patients.

Clinical Enzyme Tests↗
PubMed1980

[Anesthesia of more than 8 hours in cardiac surgery for babies 10 kg or less (author's transl)].

25 cases of total correction of complex congenital heart disease operated from January 77 to May 79 at Laënnec Hospital in Professor J. Mathey's department of thoracic and cardiovascular surgery. All 25 cases were of small weight: to kg or less. We studied the following problems: --Anaesthetic technics --Methods and means of observation --The different anomalies: .pulmonary .haemodynamical .metabolical .renal .neurological --and the different causes of death. 16 of the 25 patients studied died, 11 of whom within the first 48 hours after surgery. We concluded that in no case death can be attributed to the long duration of anaesthesia. Complications due to long-duration anaesthesia can be avoided by systematically controlling the haemodynamical, respiratory and metabolical parameters, and maintaining the viral functions within physiological limits.

Anesthesia, General↗
PubMed1979

[Accidents and complications during aorto-coronary bypass surgery. 100 cases].

Using a series of 100 patients undergoing aorto-coronary bypass surgery in the department of Professor MATHEY at Laennec Hospital, the authors analyse the incidence of accidents and complications during the per- and postoperative phases. Acute hypertensive crises accounted for the most common complication, occurring in 49 per cent of cases. The authors attribute these hypertensive crises to inadequate neuroplegia in the anaesthetic protocol. Other complications are analysed in relation to the type of myocardial protection.

Adult↗
PubMed1979

[Risk factors in coronary artery bypass surgery. 55 observations].

The incidence of complications after aorto-coronary bypass surgery were studied in a series of 55 patients in relation to the duration of extra-corporeal circulation and the value of myocardial protection. The length of the period of extra-corporeal circulation played a significant role in the onset of complications whilst there was no significant difference between the group of patients operated upon under hypothermia and those in normothermia.

Coronary Artery Bypass↗
PubMed1979

[Prevention of complications following aorto-coronary bypass surgery. Proposed solutions].

In the light of per- and post-operative complications seen in the past, the most suitable anaesthetic protocol for aorto-coronary bypass surgery would appear to be neuroleptanalgesia. This anaesthetic technique appears to decrease the incidence of per- and postoperative hypertensive crises. In addition, the use of cardioplegia also made it possible to decrease the incidence of postoperative complications in a recent group of 39 patients.

Coronary Artery Bypass↗
PubMed1978

Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha1-antitrypsin.

Alpha1-antitrypsin was assessed, in 10 patients with protein-losing enteropathy and 13 control subjects, as an endogenous marker of plasma-protein loss into the gastrointestinal tract. Both faecal alpha1-A.T. concentrations and faecal alpha1-A.T. clearance were significantly higher in patients than in controls. Wtih clearance there was no overlap between the groups. Over 10 days the normal gastrointestinal clearance of alpha1-A.T. was 3.07 +/- 2.25 (S.D.) ml/day. Measurement of alpha1-A.T. clearance is easy and requires no radioisotopes.

Adult↗
PubMed1977

[Technics of anesthesia and hypothermia for the infant. Choice of replacement fluid for the circuit].

Sixty-five infants were submitted to complete repairment of a congenital cardiopathy under profound hypothermia and ECC. Description of the preparation of the young surgical patient, of the anesthesia, of the technique of ECC. The overall mortality was 35.5 p. 100. The hypothermia induced by ECC, does not introduce any supplementary risks as long as strict technical rules are respected.

Anesthesia↗
PubMedDate not supplied

[Sulpiride: study of 669 patient presenting with pain of psychological origin].

Among somatoform disorders, pain disorder (DSM IV) appears to be relatively common in general practice and to cause social, psychological, and functional impairment. A previous study conducted by Lemoine (1997) has shown that sulpiride is more effective than placebo in reducing intensity and frequency of pain in this disorder. The aim of our study was to assess safety and efficacy of sulpiride in a large sample of patients under natural conditions of use, in general practice. In a multicenter, open clinical trial, 669 patients (mean age: 47 years +/- 12; male: 245, female: 424) fulfilling the DSM IV criteria for pain disorder (of gastrointestinal localization), were included by 321 general practitioners (GP) and treated for 6 weeks with sulpiride 150 mg/d. Investigators' evaluations were planned at D14 and D42. Furthermore a diary was given to each patient for self evaluation and intercurrent events reporting. The pain was of psychological type in 93% of cases and caused social or working disabilities in 78% of patients. At inclusion the mean score of the Hamilton Anxiety Rating Scale was 18 +/- 8, and the mean score of the depression scale HARD (Humeur, Angoisse, Ralentissement, Danger) was 14.8 +/- 6.4. During the study 7.9% of the patients had at least one adverse event, and 3% of patients were withdrawn for adverse event. Safety assessed with a specific variable (grouping together adverse events' reporting and results of CGI item 3) was good for 88% of patients. The principal criterion of efficacy was the clinician's evaluation of the intensity and frequency of abdominal pain on a four-point scale from 0 (asymptomatic) to 3 (important/continuous) from D0 to D End a decrease in pain intensity (91% of patients) and in pain frequency (89%) was observed as well as in frequency and intensity of related gastroenterological symptoms such as disturbances of bowel movements (79% and 78%), bloated symptoms (88% and 83%), nausea/vomiting (90% and 90%). A similar improvement (p < 0.001) was observed from D0 to End point on the self evaluation parameters (Visual Analogic Scales), assessing pain (mean score D0-D End: 17.1 +/- 15.9), quality of sleep (mean score D0-D End: 27.1 +/- 17.8), activity (mean score D0-D End: 24.4 +/- 18.8), and appetite (mean score D0-D End: 22.6 +/- 16.6). In conclusion these results confirm the usefulness of sulpiride in the treatment of pain disorders a symptomatology known to cause difficulties to GP's in their practice.

Abdominal Pain↗
PubMedDate not supplied

[Digestive lesions related to N.S.A.I.D. (epidemiology and prevention)].

The frequency of gastrointestinal ulcers and ulcers complications induced by non steroidal anti inflammatory drugs (NSAID) increases continuously. This is a major health problem, since 1.5% of general population (mostly elderly people) take regularly NSAID'S. NSAID'S gastropathy is asymptomatic in nearly 50% of cases, even in case of big gastric ulcer. A severe hemorrhage or a gastric perforation can occurred in the absence of previous symptoms. When the patient had epigastric symptoms during a treatment with NSAID'S, upper GI endoscopy is normal in 50% of cases. NSAID'S are ulcerogenic by decreasing the capacity of the gastric mucosa to produce prostaglandin (PG) and by weakening gastric mucosal barrier. H2 blockers are not effective to prevent such lesions. Elderly women, are at high risk of gastric mucosal lesions and complications. In a prospective study, it was shown that misoprostol was effective to reduce the rate of NSAID'S induced gastric and duodenal ulcers. Up to date, epidemiologic studies don't show any population group at no risk of NSAID'S induced gastric lesions. The actual problem, now, is to determine which groups of patients are at high risk of complication in order to clarify the indications of preventive treatment. Today, in France, it's believed that old patients, with organic pathology (respiratory, cardiac, hepatic or urinary) and/or using two or more NSAID'S are at high risk.

Aged↗
PubMedDate not supplied

[Long-term efficacy and tolerability of omeprazole in 20 patients with severe Zollinger-Ellison syndrome].

Omeprazole efficacy and tolerance were evaluated in 20 patients with longstanding Zollinger-Ellison syndrome (ZES) committed to long-term antisecretory therapy. The study included 13 men and 7 women, aged 53 (30-74) years (median and range). Nineteen patients presented with epigastric pain, 14 with vomiting, and 9 with diarrhea. All patients had gastroduodenal ulcerations, associated with esophagitis in 9 cases. Median and extreme values for basal acid output (BAO) and serum gastrin (SG) levels before omeprazole treatment were 41 (3.7-80) mmol H+/h and 413 (111-11,490) pg/ml, respectively. In 18 patients, omeprazole treatment was initiated because of resistance to H2-antagonists, and in 2 patients because of carbothioamide RP 40749 discontinuation. Initial doses of omeprazole were 60 mg per day in 10 patients and ranged from 80 to 160 mg per day in the others. Esophagogastrectomy was performed in one patient at day 15 because of esophageal stenosis. In the remaining 19 patients, median duration of treatment was 16 (7-54) months and median doses of omeprazole were 70 (20-160) mg per day during the survey. Omeprazole therapy was highly effective in inducing rapid disappearance of clinical abnormalities in 18 of 19 patients. Twenty-two days after initiation of treatment, median BAO was 4 (0-14) mmol/h and ulcerations had healed in 17 of 19 patients. Median BAO was less than 5 mmol/h during follow-up. However, asymptomatic ulcer recurrence was noted in 4 patients, but disappeared quickly after omeprazole doses were increased. Median basal gastrin level was 700 (116-36.625) pg/ml at the least determination and was statistically higher than pretreatment values (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMedDate not supplied

[Cerebrovascular accidents after endoscopic obturation of esophageal varices with isobutyl-2-cyanoacrylate in 2 patients].

We report 2 cases of cerebral stroke in cirrhotic patients following endoscopic obturation of esophageal varices with Isobutyl-2-Cyanoacrylate. In both cases, hemiplegia appeared several hours after the procedure. A brain CT scan showed radiodense material in the cerebral arteries due to dissemination of Isobutyl-2-Cyanoacrylate. One patient died, the other improved slowly. Different hypotheses may be raised: defectuous injection into the arterial circulation, systemic emboli via portopulmonary venous shunts, delayed polymerization of Isobutyl-2-Cyanoacrylate. Systemic emboli have been reported previously following percutaneous transhepatic obliteration of esophageal varices, suggesting portopulmonary venous shunts. In spite of these 2 complications, this procedure remains useful in stopping acute variceal bleeding and in preventing recurrent bleeding.

Bucrylate↗
PubMedDate not supplied

[Weakened condition of gastric mucosa barrier and hypersthenic dyspepsia].

Many patients, who suffer of heartburn or non ulcerous dyspepsia, seem to have a normal gastric mucosa (gastroscopy or histology). Potential difference is a measurement of the efficacity of mucosal barrier, and it drops when healthy volunteers ingest aspirin. By this method it is shown that patients with non ulcerous dyspepsia have a weakness of gastric mucosal barrier. Compare to controls or irritable bowel syndrome, basal potential difference is lower and time to return to basal value after aspirin is longer. This test shows that a trouble of the mucosal barrier exists even if the mucosa seems to be normal at gastroscopy and histology.

Aspirin↗