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C Foltz

Publications and source records attributed to C Foltz.

3 recordsLinked to original sources

Proof construction: adolescent development from inductive to deductive problem-solving strategies.

Inductive and deductive approaches to the construction of problem-solving proofs were examined using a task that requires the discovery of a geometrical figure hidden behind a series of covers. It was proposed that during adolescence, with the acquisition of a formal reasoning competence (as measured by Overton's [1990] version of Wason's selection task), there would be a transition from inductive to deductive proof construction strategies. One hundred adolescents were assessed on both the problem-solving proof task and the reasoning competence is associated with taking a deductive approach to proof construction. Formal reasoners tend to construct a proof based on the use of a falsification strategy as demonstrated by their search for disconfirming instances. A nonformal level of competence on the other hand is associated with inductive approaches. In this situation nonformal subjects tend to employ a verification strategy as demonstrated by the generation of redundant information. Results support the hypothesis that there is a cognitive developmental progression from an inductive approach to the construction of proofs to a deductive approach.

Adolescent

Quantitation of basement membrane collagen degradation by living tumor cells in vitro.

In order to study the mechanism of tumor cell invasion of basement membranes, a new method has been developed to quantify basement membrane (type IV) collagen degradation by living tumor cells. Tumor cells are inoculated into 16-mm tissue culture wells coatd with biosynthetically [14C]proline-labeled type IV collagen. Soluble degradation products are detected by measuring the radioactivity present in the medium. Using this method, we find that both highly metastatic and non-metastatic tumor cells and normal cells attach, but only the metastatic cells degrade the type IV collagen layer. The present data suggest that the mechanism of degradation is local activation of a latent type IV collagen specific enzyme at the cell substrate interface with no significant cell phagocytosis of substrate.

Animals