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Biomedical subjects

C Fontaine

Publications and source records attributed to C Fontaine.

At least 19 recordsLinked to original sources
PubMed2002

[Stability of the forearm after resection of the distal ulna and proximal radius in rheumatoid arthritis: report of 11 cases].

Combined resection of radial head and distal ulna could jeopardize the stability and kinematics of the forearm bones. The goals of this retrospective study was to investigate these data after resection of distal ulna and proximal radius in rheumatoid arthritis. Between 1990 and 1998, eleven patients had these bone resections combined with implantation of elbow prostheses (eight Kudo and three GSB III). Wrist surgery consisted in five wrist arthrodeses combined with Darrach procedure, four Sauvé-Kapandji procedures and two isolated Darrach procedures. Mean age at surgery was 58 years and the average follow-up was 40 months. We assessed at follow-up: 1) wrist and elbow pain according to Gschwend; 2) stability of the forearm bones (cubitus valgus angle, impingement of the proximal radial stump with humerus, giving away accident of the ulnar distal stump); 3) wrist and elbow mobility. At follow-up six patients had no pain at the elbow and five had slight occasional pain. At the wrist, five patients had no pain and six slight occasional pain. Elbow motion was increased (from mean 83 degrees [50 degrees-100 degrees] to mean 110 degrees [85 degrees-135 degrees]) excepted in supination which slightly decreased (from mean 3 degrees [40 degrees-90 degrees] to mean 75 degrees [85 degrees-90 degrees]). Mean wrist mobility was impaired because of the five combined radiocarpal arthrodeses. If these five wrist arthrodeses were excluded, the mean ranges of motion were: 10 degrees in flexion, 16 degrees in extension, 2 degrees in radial deviation, 14 degrees in ulnar deviation. At follow-up, no patient had giving away accident of the ulnar distal stump nor impingement between radial stump and humerus in full flexion. Average cubitus valgus was 10 degrees. This study pointed out the predominant effect of the interosseous membrane in stability of the forearm bones.

Adult↗
PubMed2001

Variations of pelvic anteversion in the lying and standing positions: analysis of 24 control subjects and implications for CT measurement of position of a prosthetic cup.

The position of the acetabular implant plays a dominant role in the displacement of a total hip prosthesis. CT allows precise measurement of the position of the cup, but the influence of pelvic rotation on this measurement is unknown. The aim of this study was to determine, in a group of healthy subjects, whether a pelvic equilibrium exists specific to each individual, and whether this is constant over time on the one hand and between the standing and lying positions on the other. The study concerned 15 men and 9 women with a mean age of 31 years. Each subject had strictly lateral radiographs of the pelvis, lying and standing, repeated at two different times. Pelvic version was measured in these radiographs. Each individual had a pelvic position constant over time, both in the lying and standing positions. However, there were important variations of the position of the pelvis during passage from the lying to the standing position: 22 patients had retroversion of the pelvis by a mean of 7 degrees (2-18 degrees) and 2 others had an anteversion of 3 degrees. These major variations of the pelvic position between the standing and lying positions explain why CT studies made in the lying position do not allow for the anteversion of the cup in the standing position, which is close to the dynamic situation during which displacement may occur. Thus, an excessive anteversion of the cup may be masked when the scan is made in the lying position, since in this position the anteversion of the pelvis leads to retroversion of the cup. The error may reach 20 degrees, so that we recommend that CT measurements made without allowing for the position of the pelvis should be interpreted with caution.

Adult↗
PubMed2001

Moral issues in day-to-day palliative medicine and their relevance for the education of European general practitioners.

BACKGROUND: Considerations of moral problems in palliative medicine often deal with extreme situations. This study identified moral issues arising in routine palliative medicine. Their relevance for the education of European general practitioners is assessed. METHODS: Consecutive consultations of cancer patients with incurable disease were recorded in three outpatient clinics and one general practice in Belgium. Moral issues were identified by qualitative analysis of verbal transcripts of 30 of these consultations using the grounded-theory approach. The relevance of these issues for medical education was assessed by interviewing one educator of general practitioners from each of the 15 European Union states. RESULTS: Three core categories of moral issues were identified: telling the truth, patient control versus medical dominance, and handling the patient's life-world. The practical relevance of these issues was recognized by the educators. The suggested educational methods to deal with these topics were all active learning processes in small-group settings but varied otherwise. CONCLUSIONS: The moral issues identified in day-to-day palliative medicine may complement the problems evoked in the literature dealing with more extreme situations. An effort to study the appropriate way for medical education to deal with these topics may be indicated.

Europe↗
PubMed2001

[Decompensation of lower limb arteritis after bone and joint surgery].

PURPOSE OF THE STUDY: Decompensation of lower limb arteritis after bone and joint surgery is an unusual finding compared with the large number of procedures performed in both emergency and controlled settings. There is however a functional and limb-threatening risk that must not be overlooked. MATERIAL AND METHODS: We report a series of 9 patients followed in our department over the last 3 years. Emergency surgery had been required in 6 patients after trauma and 3 had undergone a planned orthopedic procedure. All the patients had at least one vascular risk factor, and 7 of them had a cardiovascular history. The inaugural sign was a trophic disorder due to a grade IV decompensated arteritis in 8 patients, including 2 with nonunion. Delay to treatment ranged from 1 to 3 months. Acute embolic ischemia required emergency care in 1 patient. RESULTS: A revascularization procedure was performed on 6 limbs and was successful in 3. There were also 6 amputations, three initially, 1 after septic shock and 2 because revascularization was impossible. Three of the amputations were required after failed revascularization. Prosthesis wearing and walking was possible in only two amputated patients. Overall rate of successful salvage was 33% (3 successful revascularizations among 9 limbs). One of the nonunions healed after revascularization; the limb was amputated for the other one. One patient died from septicemia. DISCUSSION: Our series further illustrates the severity of decompensated arteritis after bone and joint surgery, emphasizing the importance of searching for cardiovascular risk factors and functional signs suggestive of a vascular disorder. Arterial duplex Doppler and if necessary arteriography of the lower limbs should be obtained in case of doubt. Two different situations can be distinguished depending on the predictable vascular risk and the localization of the planned bone reconstruction. If the patient has an asymptomatic proximal arteritis and bone and joint surgery is planned above the knee, a revascularization procedure would not appear necessary prior to bone surgery. In other cases, it may be more advisable to treat the arteritis before attempting bone surgery. For trauma victims, the osteosynthesis technique depends greatly on knowledge of the vascular risk.

Aged↗
PubMed2000

Study by (23)Na-NMR, (1)H-NMR, and ultraviolet spectroscopy of the thermal stability of an 11-basepair oligonucleotide.

23Na-NMR, (1)H-NMR, and ultraviolet (UV) spectroscopy have been used to study the thermal stability of the double helix structure of an 11-basepair oligonucleotide. The denaturation curves obtained by (23)Na-NMR and UV are analyzed using a two-state model. The melting temperature and DeltaH(0) obtained are identical within experimental error, suggesting that modifications in the ionic atmosphere, probed by (23)Na-NMR, and the modifications in the basepair stacking, probed by UV, occur at the same temperature. Additional dynamical information on the denaturation process has been obtained by (1)H-NMR: slow exchange is observed between the thymine methyl resonances, and the disappearance of imino protons shows that a single basepair opening does not contribute significantly to proton exchange.

Base Pairing↗
PubMed2000

Effect of the Steindler procedure on the median nerve branches to the medial epicondylar muscles.

Usually the median nerve gives off six branches to the muscles arising from the medial epicondyle, which could be tightened during Steindler's procedure. We studied these branches before and after Steindler's procedure in 20 fresh cadavers and observed a considerable variation in the origin of the branches. The muscular branches arising from the median nerve did not seem to limit the mobilization of the medial epicondyle when performing Steindler's transfer. The limitation of the flexion observed after Steindler's procedure was mainly related to the tension of the transferred forearm flexor muscles. The variability of the origin of the branch to the flexor digitorum superficialis muscle could explain a lesion of this branch when Steindler's procedure is carried out with Brunelli's modification. The lateral transfer and the anterior transfer on to the humeral shaft did not influence the limitation of elbow flexion or result in tightness in any nerve branch to the transferred muscles.

Humans↗
PubMed2000

[Rupture of the patellar ligament one month after treatment with fluoroquinolone].

Musculoskeletal disorders including arthralgia and myalgia are adverse effect common to all fluoroquinolones. We report a case of spontaneous rupture of the patellar ligament in a 37-year-old man participating in leisure sports which occurred one month after a three-week course of Ciprofloxacine(R). Several cases of tendon ruptures have been reported in the literature, including the patellar tendon. Unusual features in our case were the one-month delay before tendon rupture and the absence of inaugural signs. We reviewed the pathophysiological mechanisms leading to fluoroquinolone-related tendon rupture as well as the risk factors and discussed proper management. Care must be taken when prescribing fluoroquinolones for patients at risk. Close follow-up is most important.

Adult↗
PubMed2000

[Bankart procedure: clinical and radiological long-term outcome].

PURPOSE OF THE STUDY: There are few reports onlong-term outcome after Bankart procedure. The purpose of this study was to determine the rate of recurrent dislocation, the clinical results and the incidence of glenohumeral osteoarthritis after a minimum 10-year follow-up. MATERIAL AND METHODS: Ninety-seven Bankart procedures were performed in 97 patients between 1972 and 1986 for treatment of anterior shoulder instability with recurrent dislocations. We retrospectively reviewed 74 patients and obtained 64 complete radioclinical evaluations for an average follow-up of 16 years. Clinical evaluation was based on the G. Walch and the Duplay group score but for easier comparisons, we also calculated the Rowe et al. score. Radiographical evaluation was established on the Samilson and Prieto classification but real glenohumeral osteoarthritis with joint narrowing was noted independently as grade four. We also studied the contralateral shoulder. RESULTS: At last follow-up, 7 shoulders (9.5%) had recurrent dislocation, but two of them occurred subsequent to severe trauma over 18 months. Most patients (95 %) were satisfied or very satisfied. Six patients (8.1%) had persistent apprehension but in some it was not due to anterior apprehension. According to the Duplay score (or the Rowe score), 25 shoulders (44.6%) had an excellent result (35/61.4 %) 16 (28.6%) a good result (7/12.3%), 11 (19.7%) a fair result (11.19.3) and 4 (5.4 %) a poor result (4/7%). Operated shoulders were pain free for 75% and painful for forced movements only for 25%. External rotation at 90 degrees of abduction was reduced by 8.7 +/- 15.7 degrees. There was no limitation of internal rotation. Patients returned to preoperative sports activities at the same level for 70.9 % and at a lower level for 12.7%. According to the Samilson classification, 7 (13%) of the shoulders had grade 2 and 2 (3.7%) had grade 3 glenohumeral osteoarthritis. We found 4 cases (7.4%) of real glenohumeral osteoarthritis (grade four) and 2 of these patients had contralateral osteoarthritis of a non unstable shoulder. There was no perioperative complication. DISCUSSION: In our hands the Bankart procedure is appeared as a safe procedure with a low rate of glenohumeral osteoarthritis and a high rate of patient satisfaction.

Adolescent↗
PubMed1999

Innervation of the medial epicondylar muscles: an anatomic study in 50 cases.

The median nerve is classically distributed to the medial epicondylar muscles by two branches (superior and inferior) for the pronator teres muscle, a common trunk for the flexor carpi radialis and palmaris longus muscles, and a branch for the flexor digitorum superficialis muscle. The 50 dissections were made by two workers on 30 upper limbs of formalized cadavers and 20 limbs from fresh-frozen cadavers. The innervation of the pronator teres m. was classical in only 26% of cases, and the "normal" pattern for the flexor carpi radialis and palmaris longus mm. was found in only 40% of cases. The innervation of the flexor digitorum superficialis m. was the least subject to variations, a single branch being observed in 68% of cases. We found a solitary medio-ulnar anastomosis of Martin-Gruber to the flexor carpi ulnaris muscle. This study confirmed the great variability of the branches of the median nerve at the elbow, and the importance of identifying them in surgical procedures for transposition of the medial epicondyle.

Cadaver↗
PubMed1999

A trans STT, trans capitate perilunate dislocation of the carpus. A case report.

We report a case of carpal injury not previously described, associating three lesions of the carpus secondary to a hyperextension mechanism: fracture of the capitate, scapho-trapezio-trapezoid sprain and lunotriquetral ligament rupture. The patient was operated by percutaneous pinning after closed reduction. The capitate fracture was not fixed. At follow-up, the patient had no restriction of his everyday activities and was very satisfied.

Carpal Bones↗
PubMed1999

Esophageal cancer resection and right aortic arch: successful approach through left thoracotomy.

Esophagectomy is usually performed through a right thoracotomy because of the left position of the aortic arch. We report four cases of right-sided aortic arches in patients admitted for esophageal carcinoma. Two cases were included in total situs inversus syndrome and were thus diagnosed before esophageal carcinoma diagnosis. In these cases, the standard surgical technique was modified in a mirror image fashion and was thus performed through a left thoracotomy. The two other cases were of isolated right aortic arch and were discovered during preoperative evaluation of the esophageal carcinoma. Such asymptomatic anatomical variations have to be recognized by the esophageal surgeon because of the possible association of heart malformation and risk of iatrogenic aortotracheal or aortoesophageal fistula during tracheal or esophageal endoscopy, biopsy or intubation. Usually, esophageal resection and anastomosis are impossible through a right thoracotomy and left thoracotomy is required.

Adult↗
PubMed1999

Synovectomy combined with the Sauvé-Kapandji procedure for the rheumatoid wrist.

The aim of synovectomy-stabilization (synovectomy combined with the Sauvé-Kapandji procedure) of the rheumatoid wrist is to obtain a stable painless wrist, retaining enough mobility for function. Thirty-nine wrists were retrospectively examined, at a mean follow up of 64.8 months. The improvement in pain was very significant. We noticed a decrease in wrist motion affecting both flexion and radial deviation. The arthritic change in the wrist continued to increase. We noticed a mean ulnar shift of 2.2 mm and a mean increase in the radial deviation of the wrist of 7 degrees. Only transfer of the extensor carpi radialis longus tendon to the extensor carpi radialis brevis tendon was effective in correcting radial deviation of the carpus. Ninety-seven per cent of patients were very satisfied or satisfied. These encouraging results, even at advanced stages of wrist arthritis, have prompted us to lessen the indications for wrist arthrodesis.

Adult↗
PubMed1999

Epirubicin plus tamoxifen versus tamoxifen alone in node-positive postmenopausal patients with breast cancer: A randomized trial of the International Collaborative Cancer Group.

PURPOSE: To assess whether the addition of epirubicin (EPI) therapy to prolonged treatment with tamoxifen (TAM) improves relapse-free and overall survival in postmenopausal women with node-positive primary breast cancer. PATIENTS AND METHODS: Six hundred four patients entered onto a randomized clinical trial were allocated to receive TAM 20 mg/d for 4 years or TAM 20 mg/d for 4 years plus EPI 50 mg/m(2) intravenously on days 1 and 8 every 4 weeks for six cycles. Analysis was performed according to allocated treatment, with all randomized patients included (intention to treat), irrespective of eligibility status. RESULTS: After a median follow-up period of 5.7 years, an improvement in relapse-free survival (RFS) was observed for the TAM and EPI-treated patients, compared with those who received TAM alone. The unadjusted hazard ratio was 0.72 (95% confidence interval, 0.54 to 0.96), with a corresponding reduction in the odds of recurrence of 27.9% (SD, 12. 3), which was statistically significant (P =.023). Adjustment for prognostic and/or predictive factors did not materially affect the hazard ratio. No difference was observed in terms of overall survival (reduction in odds of death, 11.9% [SD, 16.3]; P =.46). Combined chemohormonal treatment was associated with a higher incidence of acute side effects but without a clear increase in long-term cardiotoxicity. Twelve nonbreast second malignancies, including five hematologic malignancies (two of which were cases of acute myelogenous leukemia), were observed. CONCLUSION: The data show that combined chemohormonal treatment reduces the risk of relapse in postmenopausal patients with node-positive breast cancer. No evidence was found, however, for an improvement in overall survival. The size of benefit observed for both outcomes was consistent with that reported in the Early Breast Cancer Trialists' Collaborative Group overview. The trial presented here, however, provides the first report of an improvement in RFS associated with the provision of a single cytotoxic drug in addition to prolonged TAM.

Adult↗
PubMed1999

[The biphalangy of the thumb. General review of the literature].

The thumb has only two phalanges whereas the other fingers present three. For two millennia, many anatomists tried to solve this riddle. Four different theories can be found in the review of literature, to explain what element misses in the radial column. In the first theory (Galen), the first metacarpal should be the proximal phalanx of the thumb. The particular ossification of the first metacarpal advocates for this theory. In the second theory (Sappey), the first metacarpal should result from the fusion between the true first metacarpal and the proximal phalanx of the thumb, and the proximal epiphysis should be constituted from both metacarpal and phalangeal parts. In the third theory (Paturet), the middle phalanx is thought to be missing. Apart morphological considerations, the main argument refers to symbrachydactyly, which consists in decreasing digital ray length (by reducing the middle phalanx), and usually affects digits excluding the thumb. In case the thumb is affected (in complex symbrachydactylies), the reduction concerns thus the first metacarpal, suggesting that the thumb middle phalanx has already disappeared. In the fourth theory (Pfitzner), the distal phalanx of the thumb should result from the fusion between the second and third phalanges of the thumb. This mechanism, named symphalangy, is well known in the foot, especially in the fifth toe, but also for the other toes, and even in the two ulnar fingers.

Humans↗
PubMed1999

[Right aortic arches: anatomic and embryologic classification].

Right aortic arches are rare but non exceptional abnormalities of embryonic aortic system. Sometimes responsible for tracheal or esophageal compression, they may be totally asymptomatic and fortuitously discovered. They have to be preoperatively identified in order to modify the procedure of an eventual mediastinal surgery. In this review, we describe the embryonic events which lead to these anatomical variations and the anatomosurgical classification used to precisely define their type. This anatomical definition is indispensable to adjust the surgical procedure to the consequent modification of anatomical relationships.

Aorta, Thoracic↗