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Biomedical subjects

C Franchimont

Publications and source records attributed to C Franchimont.

11 recordsLinked to original sources
PubMed1993

Effects of human growth hormone therapy on melanocytic naevi.

Melanocytic naevi may grow more rapidly during human growth hormone (hGH) therapy. With standardised skin photographs, the growth rate of the naevi was two-fold greater in 14 hypopituitary and 5 Turner's syndrome girls treated with hGH than in untreated patients or controls. HMB-45 immunoreactivity, a marker of stimulated melanocytes, was absent in naevi from 18 of 19 individuals not treated with hGH, including 5 Turner's syndrome patients studied 2-43 months after stopping hGH. In naevi from 39 hGH-treated patients, 22 showed unusual HMB-45 reactivity in dermal naevocytes. During administration of hGH, melanocytic naevi grow faster and there is reversible stimulation of naevocytes.

Adolescent↗
PubMed1982

The histological structure of Kveim tests parallels the evolution of pulmonary sarcoidosis.

The histopathology of the granulomas induced by Kveim antigen varies in patients with sarcoidosis. Eighty skin sites of Kveim tests were biopsied 4 and 5 weeks after the antigen was injected into the skin of patients with pulmonary sarcoidosis. The histological features in the skin of Kveim tests differed according to the stage of evolution of sarcoidosis and seem to parallel the pathological changes in the lung.

Granuloma↗
PubMed1982

Proliferation of the characteristic histiocyte of histiocytosis X in the skin.

The proliferation of the characteristic histiocyte of histiocytosis X in the skin of a patient with localized lesions of Hand-Schüller-Christian disease has been studied by counting cells in mitosis and cells that incorporated tritiated thymidine. The mitotic index was very low although about one-quarter of the cells were synthesizing DNA. In the deep dermis, many eosinophils were associated with a decreased tendency of the characteristic cells to synthesize DNA. We conclude that in this patient with a localized type of histiocytosis X, the characteristic cells are stimulated to enter the S phase when they are situated close to the epidermis, but there is no evidence that they divide in the skin subsequently.

Adult↗
PubMed1982

Angioplastic necrolytic migratory erythema. Unique association of necrolytic migratory erythema, extensive angioplasia, and high molecular weight glucagon-like polypeptide.

A diabetic patient developed necrolytic migratory erythema with extensive angioplasia and high molecular weight glucagon-like polypeptide. There was no associated neoplasm such as glucagonoma. Lesions in the skin were studied by standard optical microscopy and by radioautography after incorporation of tritiated thymidine. Alterations in the skin begin as focal necrosis in the epidermis and in epithelial structures of adnexa, followed by marked angioplasia and a superficial and deep perivascular dermatitis.

Adult↗
PubMed1982

Episodic progression and regression of basal cell carcinomas.

Metabolic activity and structure of the stroma adjacent to basel cell carcinomas are closely related to cytological aspects and proliferative activity of the neoplastic cells. Basal cell carcinomas without clear evidence for regression compress or infiltrate an apparently normal dermis where cellular replication is low. Conversely regressing zones of basal cell carcinomas are surrounded by a remodelled stroma where fibroblasts and endothelial cells show signs of proliferation. When regression affects the palisaded array of cells, clefts occur between the basal cell carcinoma and the adjacent stroma. Progression of most types of basal carcinomas may proceed by successive extension and partial regression. More than one type of stroma reaction may be present ina single basal cell carcinoma and the overall pattern may be regarded as the result of successive phases of growth and regression of the neoplasm.

Autoradiography↗
PubMed1980

The stratum corneum xerotic from aging and photochemotherapy (PUVA). A study by scanning electron microscopy.

The relationship between the structure and mechanical properties of the xerotic stratum corneum from aging and photochemotherapy were studied by scanning electron microscopy. Two different types or orthokeratosis were found in these xeroses, from which we infer that the type induced by PUVA does not represent accelerated aging. The orderly architectural pattern of the stratum corneum in xerosis induced by PUVA may be related to the microanatomy of the prominent undulations at the junction between the epidermis and the papillary dermis.

Adult↗
PubMed1980

Cutaneous pathobiology mediated by chemotherapy.

A histopathologic study of side effects of chemotherapy on normal skin was made by light microscopy and radioautography after incorporation of tritiated thymidine. Two psoriatic patients were studied after methotrexate treatment and one after polychemotherapy for an osteosarcoma 2--5 days after administration of methotrexate. Four biological effects can occur: cellular death, recruitment of cells from a resting phase into the cell cycle of proliferation, synchronization of cells in that cycle and blockage of cells in specific phases. Sub-lethal signs and necrosis were recognized in the epidermis as vacuolar alterations, cytoplasmic inclusions, swelling of keratinocytes, apoptosis and dyskeratosis. Bullae resulted from epidermal necrolysis. The labelling index of normal looking keratinocytes was very high. Within capillaries, plump and hyperchromatic endothelial cells were increased in number, as was their labelling index. Fibroblasts and cells of the eccrine glands were also labelled in number. The number of labelled nuclei within these cell lines reflects the recruitment and synchronization in the cell cycle and the blockage in S phase.

Adolescent↗
PubMed1980

[Diagnosis and follow-up of syphilis by serological tests (author's transl)].

Sensitivity and specificity of TPHA, TPI, RPCF, Kline's and Kolmer's tests are compared in a retrospective study carried out on 2,500 sera. The interest of these tests differs as far as diagnosis and survey of syphilis are concerned and the association of TPHA with a quantitative test as Kline's test appears optimal. TPHA is highly sensitive and specific. Its positivity, which usually remains after treatment, is particularly valuable in the diagnosis of cases of late syphilis. Its association with a quantitative test brings a better evaluation of the evolutivity of the disease.

Complement Fixation Tests↗
PubMedDate not supplied

[Bullous skin diseases].

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Diagnosis, Differential↗