PubMed Health⌕ Search

Biomedical subjects

C Fuller

Publications and source records attributed to C Fuller.

50 records · Page 3Linked to original sources
PubMedDate not supplied

A novel device for measuring the effect of cholesterol on the release of oxygen from red blood cells into myocardial tissue.

A novel method has been devised to measure the effect of cholesterol on the release of oxygen (O2) from the red blood cell (RBC) into a tailored environment, which can be made to mimic myocardial tissue. Cholesterol affects the cell membrane of the RBC and thus the release of O2 into tissue. While this is true of all tissue, the myocardium is especially sensitive because of its critical nature, its high O2 requirements, and the shortness of time that arterial blood spends in the muscle. Calculations are presented that show that the release time for O2 from RBCs is close to the residence time of the RBC in the coronary system. Sequential measurements of blood oxygen saturation (SO2) are made when oxygenated blood is subjected to conditions similar to those in the myocardium. The natural logarithm of the relative value of the SO2 at time t compared with the initial value of the SO2 can be fitted to a straight line whose slope is proportional to the parameters of the RBC membrane, the sample size, the hematocrit, and the diffusion parameters of the apparatus. This value is used to estimate the effects of cholesterol-lowering treatments on O2 release. This test will serve as a valuable adjunct to or replacement for stress tests in the evaluation of coronary artery disease, especially in patients whose physical conditions make standard stress testing painful or risky.

Algorithms↗
PubMedDate not supplied

State study of pyrotechnics-related injuries and property damage.

In December 1993, the State of North Carolina legalized the sale of certain types of fireworks. To date, no study has examined the impact of legalization of fireworks on health care and public safety. The purpose of this study was to examine the impact of legalized pyrotechnics specific to our state with regard to injury, property damage, and suppression costs. The population groups surveyed were the state fire departments, county fire marshals, hospital emergency departments, and county forest rangers. Each group was asked to complete a questionnaire on all incidents involving pyrotechnics devices, both legal and illegal, used during the study period. A total of 233 responses were received from the 1644 agencies surveyed. Forty-one injuries and 129 fireworks-related fires were reported. Total property loss was $185,570. Property loss, injury costs, and fire suppression costs totaled $799,450. This study provides a very conservative estimate of the problem within our state. Stronger legislation to restrict access to pyrotechnics may reduce the damage and costs they cause.

Blast Injuries↗