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Biomedical subjects

C Furberg

Publications and source records attributed to C Furberg.

At least 37 records · Page 2Linked to original sources
PubMed1981

The randomized clinical trial: bias in analysis.

The realization that bias in patient selection may influence the results of clinical studies has helped to establish the randomized controlled clinical trial in medical research. However, bias can be equally important at other stages of a trial, especially at the time of analysis. Withdrawing patients from consideration in the analysis because of ineligibility on account of study entry criteria, lack of compliance to the protocol, or data of poor quality may be a source of systematic error. Examples to illustrate the possible consequences are taken from trials in the cardiovascular field. We recommended that reported study results should include outcome data from all subjects randomized in the group to which they were originally assigned.

Acute Disease↗
PubMed1980

The effect of modified limb electrode positions on electrocardiographic wave amplitudes.

Mofidied limb electrode positions are often used in studies which require the recording of rest and exercise ECGs, whereby the arm electrodes are placed at the infraclavicular fossae and the left lef electrode on the left lower abdomen. The effect of the modified limb electrode positions on electrocardiographic waveforms was investigated in 68 supine adult male subjects at rest. The modification produced profound amplitude and waveform changes in the frontal plane ECG leads. The QRS axis shifted on the average by 16 degrees towards a more vertical position with considerable individual variation. Concomitant with the QRS axis shift, the R wave amplitude decreased in leads I and a VL and increased in leads II, III, and aVF. The S wave amplitude increased in leads III and aVF and decreased in lead III. The P and T wave amplitude changes were in a direction similar to those observed for the R waves: a reduction of the amplitude in aVL and an increase in II, III and aFV. Of importance to exercise ECG interpretation are the ST segment waveform changes: The ST slope decreased in aVL and increased in leads II, III and aVF. Waveform changes in the chest leads caused by the modification were less important although statistically significant. These systematic changes in recorded ECG waveforms arise from changes directions and strength of the lead vectors of the six frontal plane leads. Large inter-individual variations in the magnitude of the changes produced by modification of the limb electrode positions prevent effective systematic correction of the distortions by means of a universal lead transformation.

Adult↗
PubMed1977

Sudden coronary death in Scandinavia. A report from Scandinavian coronary heart disease registers.

UNLABELLED: All cases of acute myocardial infarction (AMI) and sudden death due to coronary heart disease have been registered in two Swedish and two Finnish cities during a 1-year period. The incidence increased steeply with age in both sexes and was in all age groups far higher in males than in females. The age-related incidence in both Finnish cities was definitely higher than in Gothenburg, Sweden, while the other Swedish register city, Boden, had an intermediate position. THE CASE: fatality rate within one year was 44.2% for males and 37.4% for females. This difference was already apparent in the first hour after the onset of the attack, when the case: fatality rate was 15.5% for males and 9.3% for females. A history of previous cardiovascular disease was much more common in AMI patients than in the general population. It was also slightly more common in subjects who died suddenly than in AMI patients who did not die suddenly.

Acute Disease↗
PubMed1975

Familial qt prolongation and risk of sudden death.

Two sisters with the syndrome of familial QT prolongation in the ECG and syncope are presented. A recently suggested mechanism of the syndrome is presented and preventive measures to reduce the risk of sudden death associated with it are proposed.

Adolescent↗