Rectal motor activity.
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Gastrointestinal Motility↗
Biomedical subjects
C Fusaro
Publications and source records attributed to C Fusaro.
Bone demineralization and impaired mineral metabolism in insulin-dependent diabetes mellitus. A possible role of magnesium deficiency.
Osteoporosis, a recognized complication of insulin-dependent diabetes mellitus (IDDM), may be related to this complex metabolic disorder; moreover, some data emphasize an altered vitamin D metabolism or parathyroid hormone secretion. Mineral homeostasis was studied in 29 children with IDDM (18 males, 11 females; 2.6-18.0 years). In 17 patients a stimulatory test (low-calcium diet) was performed for PTH and 1.25(OH)2D. Bone mineral content (BMC) and BMC/BW were lower in respect to our normal values; bone mineral loss was directly related to HbA1c levels and insulin requirements. A significant decrease of ionized calcium (p less than 0.001) and magnesium (p less than 0.001) was found; intact PTH values were in the low normal range but decreased for the ionized calcium values. 1.25(OH)2D levels were not significantly different from normal levels. 1.25(OH)2D and intact PTH did not rise during stimulatory test. The lack of 1.25(OH)2D and intact PTH increase after the stimulatory test may be due to the parathyroid gland's hyporesponsiveness related to hypomagnesemia which impaired PTH release and/or PTH action. Our data confirm an involvement of 1.25(OH)2D and PTH regulation in diabetic osteoporosis.
Adolescent↗
[Dynamic tests for calcium-regulating hormones in childhood. Evaluation of the incremental response in normal subjects].
Some tests to study the dynamic secretion of calcium-regulating hormones in childhood are presented. A low-calcium diet (less than or equal to 2 mg/kg/daily) for 1,25-dihydroxyvitamin D [1.25-(OH)-2D], ASU-eel-CT i.m. injection (80 U MRC/1.73 mq) for parathyroid hormone (PTH), and calcium infusion (2 mg/kg in 5') for calcitonin (CT) are employed. A significant increase in 1,25-(OH)-2D level (1 degree day: 47.0 +/- 6.7 pg/ml; 3 degree day: 73.2 +/- 6.9 pg/ml; p less than 0.001; n = 19), intact PTH values (basal: 29.7 +/- 7.5 pg/ml; +120': 68.2 +/- 7.8 pg/ml; p less than 0.001; n = 10) and monomeric CT concentrations (basal: 5.2 +/- 2.3 pg/ml; +10': 26.2 +/- 4.4 pg/ml; p less than 0.001; n = 18) have been observed. The employed tests are able to show a significant increase in calcium-regulating hormones in healthy children. These tests are a simple and reliable method without side-effects that may provide further information on the pathogenesis of some pediatric diseases with altered mineral homeostasis.
Adolescent↗
[Selective deficit of IgA and infantile rheumatoid arthritis. Case reports].
Three children with selective deficiency of serum IgA associated with oligoarticular juvenile rheumatoid arthritis (JRA) are presented. Before the appearance of JRA, all 3 children had shown frequently some respiratory infections. Indeed IgA deficiency may be asymptomatic or may cause a higher frequency of respiratory, gastrointestinal, allergic or autoimmune diseases, among which, JRA is one of the most important conditions.
Arthritis, Juvenile↗
[Diabetes and growth. An auxological follow-up of 36 diabetic children].
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Adolescent↗
[Abnormal synthesis of 1,25-dihydroxyvitamin D and hypercalcemia in children with tuberculosis].
Three children with tuberculosis and hypercalcemia are reported. Before antitubercular treatment 1,25-dihydroxyvitamin D serum levels and urinary calcium excretion were elevated for age in all patients; vitamin D and 25-hydroxyvitamin D were in normal range whereas serum intact parathyroid hormone concentrations were suppressed. Low calcium diet and antitubercular treatment caused a normalization of serum calcium levels and urinary calcium excretion; 1,25-dihydroxyvitamin D concentrations returned in normal range after three months of antituberculosis therapy. When 1,25-dihydroxyvitamin D was normal, a reintroduction of a diet with normal calcium content did not determine new hypercalcemic episodes. These data suggest that an abnormal 1,25-dihydroxyvitamin D production sustains the hypercalcemia of children with tuberculosis. An ectopic and unregulated synthesis of 1,25-dihydroxyvitamin D by macrophages of granulomatous tissue is proposed.
Calcium↗
Autonomic functions in type 1 (insulin-dependent) diabetes.
In juvenile type 1 diabetes a computer-aided orthoclinostatic test, giving information on central autonomic reactivity, shows a significant difference, vs control subjects, only in the ortho-to-clino transition (not in clino-to-ortho), while no differences emerge in peripheral autonomic functions. The correlations between the mean values of heart rate in lying and standing positions seem to indicate a different response of the baroceptor reflex in the two groups.
Adolescent↗