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Biomedical subjects

C G Long

Publications and source records attributed to C G Long.

At least 19 recordsLinked to original sources
PubMed1998

Treating alcohol problems: a study of programme effectiveness and cost effectiveness according to length and delivery of treatment.

AIMS: To compare effectiveness and cost-effectiveness of a 5-week inpatient and a two week in- and day-patient regime. DESIGN: Pre-post assessment of consecutive treatment referrals with follow-up at 6 and 12 months. In a sequential study design, 112 patients underwent a 5-week residential programme while a subsequent 100 patients underwent a 2-week in- and day-patient programme. To investigate the effect of changing programme delivery, patient groups from before and after the programme changes were compared. SETTING: Addiction treatment unit in an independent hospital. PARTICIPANTS: One hundred and thirty-six males and 76 female patients with an ICD-10 diagnosis of Alcohol Dependence Syndrome. MEASUREMENTS: Self-report (Comprehensive Drinkers Profile: Follow-Up Drinkers Profile: SADQ), collateral report (Collateral Interview Form) and blood test (MCV & GGT) data were used to categorize patients into abstinent, non-problem drinker, drinking but improved and unimproved groups. Percentage of days abstinent, intensity of drinking, length of time in treatment, treatment cost and use of aftercare were also measured. FINDINGS: Abstinence or non-problem drinking was achieved by 55.6% of all patients at 1 year. Change in programme delivery did not affect outcome but treatment costs and mean length of stay for the revised programme were significantly reduced. CONCLUSIONS: A two week in- and day-patient treatment was more cost effective than a 5-week inpatient treatment. Design limitations make these conclusions tentative pending a randomized controlled trial.

Alcoholism↗
PubMed1998

Self-efficacy, outcome expectations, and fantasies as predictors of alcoholics' postreatment drinking.

The usefulness of distinguishing between alcoholic patients' expectations and their fantasies about treatment outcome was examined. Results at 6 and 12 months follow-up did not support the results of research with nonalcoholic participants which related better outcomes to a combination of positive expectations and negative fantasies about future drink-related situations. Higher self-efficacy expectancy at intake, however, was associated with better clinical outcome. Findings supported Bandura's (1986) contention that outcome expectations add little information on prediction beyond that explained by self-efficacy expectancy. The clinical implications of these results are discussed.

Adult↗
PubMed1995

Atypical Gly-X-Y sequences surround interruptions in the repeating tripeptide pattern of basement membrane collagen.

The triple-helical domains of type IV collagen chains have more than 20 sites at which the repeating (Gly-X-Y)n pattern is interrupted. Analysis of alpha 1 (IV) and alpha 2 (IV) chains indicates the residues in the three Gly-X-Y triplets preceding or following interruptions differ statistically from the rest of the chain. Unusually high frequencies of charged residues are seen at a number of X and Y sites, with the charge density being particularly high C-terminal to the interruption site. Analyses were carried out on individual categories of interruptions, classified as insertions or deletions in the Y position. All of the residues in the X and Y positions of the triplets flanking insertion sites are atypical, with a high concentration of charged residues. Triplets flanking sites where there has been a deletion in the Y position show unusually high frequencies of charged residues at some sites, hydrophobic residues at other sites, and an invariant imino acid N-terminal to the interruption. The presence of atypical sequences surrounding interruptions could be important at a molecular level, related to triple-helix stability, or at a supramolecular level, related to the association of molecules to form networks in basement membranes.

Animals↗
PubMed1995

Staff perceptions of organization change of treatment delivery on an addiction unit.

The Work Environment Scale was used to assess staff perceptions of a change in a treatment programme for problem drinkers. A more cost-effective 2-week research-based day-patient programme, which included the concept of matching, replaced a 5-week cognitive behavioural in-patient programme. The maintenance of a positive work environment was attributed to the meeting of staff expectations, a cognitive behavioural ideology, and the establishment of a research culture. The study highlights the importance of the thorough preparation of staff for change, and their active involvement in the process in settings where work satisfaction is already above the average level for mental health facilities.

Alcoholism↗
PubMed1994

Selective processing of food and body size words: application of the Stroop Test with obese restrained eaters, anorexics, and normals.

The specificity of the retardation effect on the Stroop Naming task with eating disorder clients was examined by comparing anorexic patients and normal weight controls with obese restrained eaters. Although the expected differences between normal weight controls and anorexics were found for color naming of food and body size words, obese restrained eaters were not differentiated from the clinical sample. It is suggested, therefore, that the Stroop phenomena do not have a precise relationship to the extent of psychopathology and that factors such as the ability to "fake" the test and poor concentration leading to general slowing, may explain the results.

Adolescent↗
PubMed1993

Characterization of collagen-like peptides containing interruptions in the repeating Gly-X-Y sequence.

Glycine is found as every third residue along the entire length of triple helices in fibrillar collagens, but the triple-helix regions of nonfibrillar collagens and other proteins usually contain one or more interruptions in this repeating pattern. A set of four peptides was designed to model the effect of interruptions in the (Gly-X-Y)n repeating pattern on triple-helix formation, stability, and folding. Into the middle of the stable triple-helical peptide (Pro-Hyp-Gly)10, an interruption was introduced representing one of the four possible categories: a glycine deletion, a deletion of a hydroxyproline (Y position), an alanine insertion, or a glycine to alanine substitution. As shown by sedimentation equilibrium, NMR, and CD studies, the introduction of an interruption still allowed formation of trimers in solution, but with marked decrease in stability. The degree of destabilization and the thermodynamic basis for the loss of stability depended on the type of interruption. The glycine substitution and alanine insertion were the least disruptive, followed by the hydroxyproline deletion, with the glycine deletion being the most destabilizing. Our results suggest that the breaks in these peptides affect both the triple-helical conformation and the monomer conformation. These studies provide a basis for considering the structural and functional consequences of different kinds of interruptions in collagen.

Amino Acid Sequence↗
PubMed1993

The behavioral treatment of self-starvation and severe self-injury in a patient with borderline personality disorder.

The successful treatment by behavioral methods of self-starvation and self-injury in a 35-year-old psychiatric in-patient, with a diagnosis of borderline personality disorder, is described. An individualized program using positive and negative reinforcers to increase food and fluid intake was used, while a token economy therapeutic milieu with time out was used to decrease acts of self-injury and aggression. Progress in treatment generalized to a non-secure treatment environment, and was maintained at an 8-month follow-up. The study illustrates the differential response of active and passive self injurious behaviors to group-based and individual treatments, respectively.

Adult↗
PubMed1992

Nuclear magnetic resonance and circular dichroism studies of a triple-helical peptide with a glycine substitution.

The triple-helical conformation has the stringent amino acid sequence constraint that every third residue must be a glycine, (X-Y-Gly)n. We use nuclear magnetic resonance and circular dichroism to quantify the consequences of a substitution in the glycine position of a triple-helical peptide, and to enhance our understanding of interactions in this basic structural motif. A 30-residue peptide with a Gly----Ala change forms a stable trimer at a folding rate somewhat less than that of the unsubstituted peptide, and the substitution results in a marked decrease in thermal stability and a conformational perturbation of about 30% of the triple-helical structure. Two models were generated for this peptide, one with the alanine residues packed inside the triple helix and one with a looping out of the chain at the substitution site. Studies on the Gly----Ala peptide are useful in understanding connective tissue diseases which result from the substitution of one glycine residue in the triple-helix of fibrillar collagens.

Circular Dichroism↗
PubMed1992

NMR and CD studies of triple-helical peptides.

Triple-helix formation of the peptide (Pro-Hyp-Gly)10 was monitored by nmr and CD spectroscopy. The two-dimensional nmr spectra indicated that the Gly C alpha H and Pro C delta H proton resonances shift upfield in going from the nonhelical to helical form, while hydroxy-proline resonances are unchanged. The integrated areas of the helical and nonhelical resonances could be monitored in the one-dimensional nmr spectrum, and indicate that in the (Pro-Hyp-Gly)10 about 90% of the residues are in a defined triple-helical conformation. The introduction of a glycine to alanine substitution or the deletion of a single hydroxyproline residue in the stable triple-helical peptide (Pro-Hyp-Gly)10 still allows trimers to be formed, but the trimers show a substantial loss of triple helix and decreased thermal stability compared with (Pro-Hyp-Gly)10. Two computer models were generated for the Gly----Ala peptide, one with the Ala side chains packed inside the helix and the other with the region containing the alanines forming a beta-bend that loops out from the helix. The nmr data is more consistent with the latter model.

Amino Acid Sequence↗
PubMed1992

An evaluation of two systems of in-patient care in a general hospital psychiatric unit I: staff and patient perceptions and attitudes.

This study reports a comparison of a single ward versus a two-ward system of acute in-patient care in a general hospital psychiatric unit. It focuses on staff and patient perceptions and attitudes towards the two types of ward. A continuous care ward system was preferred by the majority of staff who described an improvement in 'ward atmosphere'. Patients who had experienced both ward systems also preferred the continuous care system. Both patients and staff felt that the continuous care system still needed to place greater emphasis on 'ward atmosphere' dimensions of involvement, support and spontaneity. The implications of these findings for improving the functioning of the preferred ward are discussed.

Adult↗
PubMed1990

An evaluation of two systems of in-patient care in a general hospital psychiatric unit. II: Measures of staff and patient performance.

This study reports on a comparison between a single ward and a two-ward system of acute in-patient care in a general hospital psychiatric unit. It looked at job satisfaction, levels of stress, absenteeism/sickness and work proficiency amongst the staff and also at patients' level of disturbed behaviour, length of stay and re-admission rates. It was found that a continuous-care ward was associated with a lower level of behavioural disturbance and was preferred by the majority of staff, with some increase in job satisfaction and a decrease in stress. The continuous-care ward was also associated with shorter admissions. However, those who progressed through a two-ward system were less likely to be re-admitted within 3 months. The implications of these results are discussed.

Absenteeism↗
PubMed1989

Low alcohol beers and wines: attitudes of problem drinkers to their use and their effect on craving.

Thirty-one inpatient and 67 expatient problem drinkers' use of low alcohol drinks and their attitudes towards them were assessed using questionnaire measures. Self ratings of craving for alcohol were made before and after exposure to and optional tasting of low alcohol drinks. Problem drinkers were found to have a generally favourable view of low alcohol drinks, and they claimed that use of these drinks did not contribute to relapse. However, craving for alcohol was found to be significantly raised over baseline after exposure to low alcohol drinks. A significant correlation was found between this increase in craving and severity of dependence as assessed by the SADQ.

Adult↗
PubMed1988

Group coping skills training for anxiety and depression: its application with chronic patients.

The literature on group coping skills training is reviewed and a model involving the use of a wide range of coping strategies with patients heterogeneous in terms of presenting problem is advocated. This study evaluates the effect of such an approach with a chronic inpatient and day-hospital patient population (n = 36) presenting with problems of anxiety and depression. Results suggest that the use of such groups can facilitate the transition from hospital to community. Further they are associated with symptomatic improvement that is of clinical significance in up to 50% of cases, which is largely maintained at 1 year follow-up and which is associated with a positive change in social functioning. In the light of this experience suggestions are made regarding the screening of patients and ways of enhancing group cohesion.

Adaptation, Psychological↗
PubMed1988

Inhibition of mannosidase in hybridomas yields monoclonal antibodies with greater capacity for carbohydrate labeling.

Labeling an antibody site specifically through its carbohydrate residues preserves more of its antigen-binding activity than does labeling through protein moieties. To boost the amount of immunoglobulin G carbohydrate capable of being labeled, we treated hybridoma cells with a mannosidase inhibitor, deoxymannojirimycin (dMM). Polyacrylamide gel electrophoresis showed formation of a glycoprotein with high mannose content, in that endo-beta-N-acetylglucosaminidase H (EC 3.2.1.96) could digest the antibody from the dMM-treated cells, but not from control cultures. Carbohydrate analysis confirmed this conclusion, indicating that the antibody from the dMM-treated cells had twice as much mannose as did the control antibody. The glucosamine content of the treated-cells' antibodies was half that of the control, and no additional carbohydrate residues were detectable in the antibodies secreted by the dMM-treated cells. We conjugated both the dMM and control antibodies through their carbohydrate to a chelator. In labeling, the dMM antibody conjugate incorporated approximately threefold as much 111In isotope as the control conjugate. The two labeled antibodies were injected into mice and showed similar organ distributions.

1-Deoxynojirimycin↗
PubMed1987

Linking professional and self-help resources for anxiety management: a community project.

The first two years of an anxiety management project involving close liaison between general practitioners, clinical psychologists and a self-help group is described. The apparent benefits of this programme to clients in terms of prompt delivery of service and symptom and medication reduction are discussed. In the light of this a model that combines the benefits of the self-help movement with an appropriate level of professional support is advocated as a viable referral option for the large number of patients with anxiety related problems that present to general practitioners.

Adult↗
PubMed1985

Parental pressure for tonsillectomy: attitudes and knowledge of parents accompanying their children to an ear, nose and throat clinic.

The parents of 120 children referred for possible tonsillectomy to an ear, nose and throat (ENT) surgeon were studied. There was no evidence that a desire for the operation fulfilled 'psychological needs' for parents or was a means of coping with a 'deviant' child. Parents favouring tonsillectomy were less well informed, and the educational role of the general practitioner in reducing the small number of those who inappropriately pressurize medical services is highlighted.

Adolescent↗
PubMed1983

Psychological and dietetic counselling combined in the treatment of obesity: a comparative study in a hospital outpatient clinic.

This study examined the effectiveness of combining behaviour modification with dietetic counselling in a hospital outpatient clinic. Thirty-six females with an obesity index over 25 were placed in one of three 16-week treatment conditions: (1) individual dietetic counselling, (2) group dietetic counselling, (3) group dietetic counselling with behaviour modification. Median end of treatment weight losses were 8.3, 4.6 and 6.9 kg respectively. At one year follow-up patients in Gp 2 tended to have regained their weight while patients in Gps 1 and 3 were equally successful in maintaining weight loss. However, trends towards lower rates of attrition, slower rates of decay of treatment effects and a more economical use of professional time favoured the dietetic behavioural group condition as a treatment choice. In view of the successful use of behavioural techniques by a variety of professions their wider employment by dietitians is advocated.

Adolescent↗