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Biomedical subjects

C G van Oostrom

Publications and source records attributed to C G van Oostrom.

18 recordsLinked to original sources
PubMed1994

Neurological complications in children with protein C deficiency.

Four children with a cerebrovascular occlusive accident and protein C deficiency are described. Two patients presented with an acute hemiplegia, the others suffered from a transient ischemic attack and a progressive hydrocephalus as the result of sinus thrombosis. In all cases protein C deficiency, Type 1, was diagnosed. Other causes of cerebrovascular disease were excluded. Although venous thrombosis has been extensively reported in protein C deficiency, these cases indicate that protein C deficiency is also related to arterial thrombosis. In evaluating children with cerebrovascular accidents, protein C deficiency should also be considered.

Adult↗
PubMed1992

Vitamin K status in cystic fibrosis.

Appearance of PIVKA-II (protein induced by vitamin K absence-II) in serum is a biochemical sign of insufficient vitamin K-dependent carboxylation of prothrombin. Plasma concentrations of PIVKA-II and vitamin K1 were determined in 24 children with cystic fibrosis. Eight were supplemented with vitamin K1. The purpose of the study was to determine the occurrence of vitamin K deficiency in cystic fibrosis and to evaluate the effect of vitamin K supplementation. PIVKA-II was detectable in only one unsupplemented child. In this patient, the concentration of vitamin K1 was below the limit of detection of 60 ng/l. Vitamin K1 levels in the other unsupplemented children were normal (mean 476 ng/l = 1 mmol/l). The supplemented patients showed extremely high levels of vitamin K1 (mean 22445 ng/l = 50 nmol/l). In conclusion, vitamin K deficiency occurs infrequently in cystic fibrosis. Checking the coagulation system is advised, but routine vitamin K supplementation is not recommended. If additional vitamin K is needed, the starting dose should not exceed 1 mg daily.

Adolescent↗
PubMed1990

[sports by children with a bleeding tendency].

In children with bleeding tendency it is a dilemma to go in for sports. The risks and benefits are to be weighed against each other. Mostly there is no need to impede the child's activities. Several sports that safely can be played by children with hemorrhagic diathesis are summed up. Specific aspects of sports by children with thrombocytopenia, Von Willebrand's disease, hemophilia and thrombasthenia are discussed.

Child↗
PubMed1984

Transient erythroblastopenia of childhood. A review of 22 cases.

In the period 1975-1983 22 patients, aged 4-36 months were seen with severe transient normochromic, normocytic anaemia caused by a transient erythroblastopenia. In 20 patients bone marrow aspirations were obtained; they showed erythroblastopenia. In ten cases we observed young lymphoid cells, suggesting a diagnosis of acute lymphoblastic leukaemia. One patient suspected of a leukaemia, was studied in more detail. All patients showed reticulocytopenia. MCV and HbF were within normal range. During recovery reticulocytosis and higher levels of HbF were found. Except for blood transfusion in most patients, therapy (e.g. corticosteroids) was not necessary. Spontaneous recovery is a feature of this kind of erythroblastopenia, contrasting with congenital hypoplastic anaemia.

Anemia, Aplastic↗