Biomedical subjects

C García Lacalle

Publications and source records attributed to C García Lacalle.

3 recordsLinked to original sources

PubMed2003

[Values of thyrotropin, free triiodothyronine and free thyroxine using chemiluminescence in children and adolescents in the Autonomous Community of Madrid (Spain)].

OBJECTIVE: To establish the reference ranges of thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) with the chemiluminescence method in healthy children and adolescents in Madrid, Spain. METHOD: A total of 371 children and adolescents of both sexes, with different ages and at different pubertal stage participated in the study. Serum values of TSH, FT3, and FT4 were determined by chemiluminescence. RESULTS: TSH, FT4 and FT3 reference ranges decreased inversely with chronological age. Significant differences were found between prepubertal and pubertal groups. In some groups, there were also occasional differences between sexes. CONCLUSIONS: Thyroid hormone levels decrease with chronological age. Because of the differences in hormone levels between prepubertal and pubertal subjects, we believe that different pubertal stages should be included in the standard reference values of these hormones.

Adolescent↗

PubMed2003

[Once-daily gentamicin dosing versus thrice-daily dosing in infants with acute pyelonephritis].

BACKGROUND: Once-daily dosing (ODD) of gentamicin is advocated as an effective and safe treatment of Gram-negative bacterial infections in adults. There are insufficient data in the literature to justify its use in infants. OBJECTIVES: To compare the efficacy of ODD of gentamicin with that of classical thrice-daily (t.i.d.) administration in infants with acute pyelonephritis. METHODS: We performed a quasi-experimental study comparing 33 infants who received ODD of gentamicin with a historical control group of 25 infants treated with gentamicin t.i.d. Leukocytosis, C-reactive protein, creatinine, gentamicin dose, peak and trough values, time required for disappearance of fever, and outcome were analyzed. RESULTS: The mean doses of gentamicin (mg/kg/day) were higher in the t.i.d. group (6.4 1.14) than in the ODD group (5.06 0.22; p < 0.001). Peak serum gentamicin concentrations (micro g/ml) were significantly higher in the ODD group (9.32 1.4) than in the t.i.d. group (5.09 1.15; p < 0.001). Mean trough gentamicin concentrations (micro g/ml) were lower in the ODD group than in the t.i.d. group (0.23 0.26 vs 0.78 0.45; p 0.001). There were no significant differences in the duration of fever between the groups (30.64 32 hours in the t.i.d. group vs. 28.57 32 hours in the ODD group). Serum creatinine levels were normal during treatment in both groups. In all patients outcome was good and no adverse effects were noted. CONCLUSIONS: Treatment with ODD of gentamicin in our population of infants with acute pyelonephritis was as effective as traditional administration t.i.d. and possibly was equally safe or safer.

Acute Disease↗

PubMed1989

[Type C hereditary brachydactyly].

We report 2 generations with type C hereditary brachydactyly of dominant autosomal inheritance of variable expressiveness. The most characteristic data was the shortening of the middle phalanges of the second, third and fifth finger as well as the first metacarpal. Short stature was observed in three of the patients studied. The goal of this study was aimed at stimulating GH pharmacologically and determining its 24 h physiologic secretion, as well as somatomedin C levels. All the determinations were within the normal range. The deficient growth shown by these patients is a constitutional growth delay, possibly an expression of type C brachydactyly.

Child, Preschool↗