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Biomedical subjects

C García-Carrillo

Publications and source records attributed to C García-Carrillo.

16 recordsLinked to original sources
PubMed1989

Probability of introducing diseases because of false negative test results.

The use of diagnostic tests for the selection of healthy individual persons or animals for inclusion in certain groups carries with it an inherent risk of including those with infections because they falsely reacted negatively. The factors of sensitivity of the test, prevalence of the disease, and the size of the group all influence the degree of such risk. The probability of including an infected individual person or animal can be calculated combining conditional probability and the binomial distribution.

Animals↗
PubMedDate not supplied

[Evaluation of the myeloculture by puncture of the ilium crest for isolation of Brucella from patients with brucellosis].

Hemocultures and myelocultures of samples obtained from the ilium crest were made simultaneously of 61 patients with serologic diagnosis of brucellosis. Five strains were isolated by both methods and 18, by myeloculture only. All samples from which Brucella were isolated by hemoculture were also positive by myeloculture. The advantages of making myelocultures of patients previously treated with antibiotics are emphasized.

Adult↗
PubMedDate not supplied

[Phenol-insoluble vaccine against human brucellosis: evaluation of the immunogenic power in guinea pigs].

A phenol insoluble extract vaccine proposed to immunize men against brucellosis was tested for its ability in protecting guinea pigs against challenge with virulent Brucella abortus strain 2308. Living attenuated Brucella abortus strain 19 and B. melitensis Rev. 1 were included in the experiment for comparison. Ninety three animals were vaccinated in each group and subdivided in subgroups of 31 for challenge with 10(4), 10(3) and 10(2) colony forming units of virulent B. abortus 2308. A global analysis of the results showed protection of 11.9%, 65% and 95% in animals vaccinated with phenol insoluble extract, strain 19 and Rev. 1, respectively.

Animals↗
PubMedDate not supplied

[Cell survival of the Brucella abortus strain 19 vaccine during the lyophilization process according to the vehicle used].

Ten stabilizing media commonly used by commercial laboratories for the stabilization of Brucella abortus strain 19 for lyophilization were studied. Six media gave similar results, with viable count averages ranging from 50% to 58%. The standard stabilizer recommended by the World Health Organization (casitone 2,5%, sucrose 5% and sodium glutamate 1%) was included. The other four media gave viabilities with averages from 19,7% to 38,7%, which represented a highly significant difference. The lowest viable count was observed with the 5% polyvinylpyrrolidone stabilizer. The differences in the number of viable cells among the various processes were greater than expected.

Brucella Vaccine↗