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Biomedical subjects

C Garel

Publications and source records attributed to C Garel.

53 records · Page 3Linked to original sources
PubMed1997

[Imaging of meconium peritonitis of pseudotumor clinical presentation].

An unusual case of meconium peritonitis is reported. A neonate presented with a huge multiseptate effusion in the peritoneal cavity in relation with a small bowel perforation. No calcification was visible. Such a presentation cannot be included in one of the classical types of meconium peritonitis. It could be due to a bowel perforation occurring immediately before birth and could therefore be related to a mixed fibroadhesive and generalized form.

Diagnosis, Differential↗
PubMed1996

[Magnetic resonance imaging of the fetus. Contribution to antenatal diagnosis].

Magnetic resonance imaging (MRI) of the fetus has been developed over the last 10 to 15 years. This new imaging technique cannot remplace ultrasonography which remains the key examination for antenatal diagnosis but can add further improvements over ultrasonographic findings, particularly in evaluating the fetal brain. MRI of the fetus has thus been focused in this area, the main studies aiming at analyzing brain malformations and at searching for ischemic or hemorrhagic lesions and possible gyration anomalies. Advances in data processing software and volume acquisition and the development of the echo-planar technique and T2-weighted sequences are currently under study. MRI of the fetus has thus progressed rapidly. It is however a long costly examination which may not be well tolerated by pregnant women. Currently, routine MRI of the fetus is not possible, because of the requirement for specialized facilities. This new technique, still in the evaluation phase, should be studied using strict protocols reserved for centers specialized in antenatal diagnosis.

Female↗
PubMed1996

Nasal pyriform aperture stenosis and absence of the anterior pituitary gland: report of two cases.

We describe two female infants with congenital nasal pyriform aperture stenosis and severe pituitary insufficiency. The anterior pituitary gland was undetectable with magnetic resonance imaging. Consanguinity of parents in both cases suggests autosomal recessive inheritance of this disorder. An early fetal developmental defect may explain this syndrome, which affects midline craniofacial structures. In patients with congenital pyriform aperture stenosis, magnetic resonance imaging of the brain and endocrine investigations should be performed for rapid diagnosis and treatment of the latter to avoid major neurologic complications.

Abnormalities, Multiple↗
PubMed1995

Foetal and neonatal splenic cyst-like lesions. US follow-up of seven cases.

Seven cases of small, asymptomatic splenic cyst-like lesions (CLL) diagnosed in foetuses and neonates are reported. None of these CLL was operated on; three completely disappeared. Such a complete regression has never been described before. A more conservative app approach to such lesions is suggested in order to prevent the possible complications of inappropriate interventional therapy.

Cysts↗
PubMed1995

Interleukin-6 and interleukin-1 beta production in a pediatric plasma cell granuloma of the lung.

Plasma cell granuloma (PCG) is a pseudotumor of unknown origin. It is frequently accompanied by acute-phase clinical and biological signs that resume after complete surgical removal, suggesting production of soluble mediators. We therefore investigated the role of cytokines in a previously healthy 10-year-old boy with a PCG of the lung and systemic symptoms. In this case, very high serum levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) were found before tumor excision, associated with inflammatory signs including major hyper-gamma-globulinemia. Pathologic analysis of the tumor showed an accumulation of fibroblasts and plasma cells producing immunoglobulins. Local production of IL-1 beta and IL-6 could be demonstrated at the messenger RNA (mRNA) level by the reverse transcriptase polymerase chain reaction and could be attributed to inflammatory cells by in situ hybridization and immunohistochemistry, whereas plasma cells exhibited membrane expression of the IL-6 receptor. Postsurgery follow-up showed rapid normalization of serum IL-1 beta and IL-6, whereas inflammatory protein levels decreased. This confirms the local production of cytokine within the PCG and raises the question of whether a dysregulation of cytokine production initiates the disease.

Base Sequence↗
PubMed1994

Ultrasonographic evaluation of the tongue and the floor of the mouth: normal and pathological findings.

An ultrasonographic study of the tongue and the floor of the mouth was performed in 30 healthy children (aged from 1 day to 15 years) in order to assess the normal US anatomy of this region. The scans were performed in sagittal and coronal planes with a 7.5-mHz transducer. Moreover, 22 children (aged from 1 day to 15 years) presenting with various clinical symptoms underwent US examination. This series included infectious and congenital diseases. The US findings were correlated with surgery and pathology in 19 cases, with the clinical follow-up in 2 cases and with the nuclear study in 1 case. In each case, US could anatomically locate the lesion with very good accuracy. We conclude that US of the tongue and the floor of the mouth in children yields overall very good accuracy in the investigation of diseases of this region. In this study, our purpose was (1) to evaluate the normal sonographic anatomy of the tongue and the floor of the mouth in children and (2) to determine whether it was possible to correctly localize various lesions and to evaluate their nature in order to guide the therapeutic approach.

Adolescent↗
PubMed1994

[Dysphagia in children. Imaging].

While oesophageal obstacles are responsible for regurgitation or aspiration in neonates and infants, older children present with dysphagia. Before any investigation, a buccopharyngeal infection must first be eliminated clinically. In the absence of fever, the ingestion of a foreign body or caustic substances must be considered, either in an acute context, or in a chronic context related to cicatricial stenosis. Tumour or congenital lesions are less common, whether intrinsic (stenosis, fistulas, duplications), or extrinsic (vascular malformations, mediastinal tumours). Radiological investigation is based on simple techniques: chest X-ray and barium swallow are usually sufficient to establish the aetiological diagnosis.

Adolescent↗
PubMed1994

[Morphological abnormalities of the pituitary stalk of unknown cause in 4 cases of diabetes insipidus in children].

BACKGROUND: Magnetic resonance imaging (MRI) is the best technique for studying hypothalamic and hypophyseal structures. CASE REPORTS: Four children aged 2 years 5 months to 8 years with idiopathic diabetes insipidus were studied. Their condition had been identified for 2-6 years. All the patients had undergone complete clinical, neurological and endocrinological investigations during the search for the cause of their diabetes insipidus. A CT scan was performed in one patient and MRI in all four; the investigations were repeated each 6 months for 4 years. RESULTS: The first examination showed complete lack of antidiuretic hormone (four patients) and growth hormone deficiency (two patients). An enlarged pituitary stalk was seen in three patients, one patient had a small anterior pituitary, and three patients gave no posterior pituitary hypersignal. Follow-up showed that three patients completely lacked of growth hormone. One was thyrotropin deficient, three had persistent enlarged pituitary stalks, three had sub-normal anterior pituitaries and all four patients produced no post-pituitary hypersignal. None of the patients developed signs of histiocytosis or germinoma. CONCLUSION: The finding of abnormal pituitary stalks by MRI raises the possibility that the apparently idiopathic diabetes insipidus is due to some type of infiltrating disease of the hypothalamus and pituitary.

Child↗
PubMed1992

Contribution of MR in the diagnosis of 'occult' posterior laryngeal cleft.

This paper reports three cases of 'occult' submucous posterior laryngeal cleft in which MR examination has visualized the deficiency of the posterior cricoid lamina. Laryngeal cleft is an uncommon anomaly, and its clinical and endoscopic diagnosis is always difficult. To our knowledge, the role of MR in this diagnosis has not yet been emphasized.

Cricoid Cartilage↗
PubMed1992

Tracheal rupture in a newborn during a complicated delivery. Diagnosis and surgical repair.

Rupture of the trachea is an exceptional obstetrical lesion. The infant reported in this paper, at 1 hour of age, developed respiratory distress with pneumomediastinum, bilateral pneumothorax and subcutaneous emphysema. This resulted from the fact that the trachea had ruptured, within 1 cm of the carina, during the difficult delivery. When the child was 23 days old, operation proved necessary because extubation was not feasible. The stenotic portion of the trachea was resected and continuity restored by end-to-end anastomosis. The tracheal lumen at the site of the anastomosis proved normal by bronchoscopic examination 4 months after the operation. There is only one similar case in the literature. The etiology of this rupture is discussed.

Birth Injuries↗
PubMed1992

[Dimensions of the pharynx in function of the posture, in neonates and infants].

The authors measured the pharyngeal patency of 25 wakeful newborns and infants on X-ray films of the lateral upper airway. The upper airway patency depends on the head position. The velopharyngeal and the posterior tongue space are smaller in supine position than in ventral position. In supine position the airway space behind the base of the tongue is significantly greater when the head is extended than when the head is in neutral position (p less than 0.007).

Head↗
PubMed1991

Laryngeal ultrasonography in infants and children: pathological findings.

In a previous paper, the normal sonographic anatomy of the larynx has been described. The pathological findings of this method, its advantages and its drawbacks are now discussed and compared to endoscopy and plain films. It appears to be a very interesting method for functional disorders and space-occupying lesions.

Adolescent↗
PubMed1991

[Balloon dilatation of tracheobronchial stenoses in children. Apropos of 4 cases].

Long-lasting tracheal tubing in newborns and infants, associated with repeated tracheobronchial aspiration, is sometimes complicated by tracheal and/or bronchial stenoses. Many therapeutic methods have been described to treat this condition: use of dilatators, laser, surgery, insertion of prosthetic material. Dilatation with an angioplasty balloon has been recently described for the treatment of various stenoses. The authors report about 3 cases of acquired tracheobronchial stenosis which were successfully treated with this method, and 1 case of complex tracheal stenosis (with a double inflammatory and congenital nature) which required both dilatation and surgery. The technique is described. There is no morbidity and no mortality in this non-randomized series. Balloon dilatation is a simple and effective method, which may be proposed as a first-intention treatment for acquired tracheobronchial stenosis in newborns and infants.

Bronchial Diseases↗
PubMed1990

Laryngeal ultrasonography in infants and children: anatomical correlation with fetal preparations.

Normal sonographic anatomy of the larynx in children was established by studying 40 healthy children and 3 fetuses. The normal anatomy is described on transverse sonograms passing at level of the ventricular bands, the true vocal cords and the subglottis and the interpretation of the sonographic aspect of the larynx is given. Ultrasound of the larynx seems to provide a good analysis of cartilaginous and endolaryngeal structures and can also show the dynamic aspect of the larynx. A pathological case is described as an illustration of the potentialities of this new way of imaging the larynx.

Adolescent↗
PubMed1990

[Contribution of sectional imaging, echography and MRI, for the diagnosis of splenic infarction in Osler endocarditis. Apropos of a case].

A case of symptomatic splenic infarct in an 11 year-old girl suffering from bacterial endocarditis is reported; this occurrence is a rare and serious condition in this disease. The diagnosis of haemorrhagic splenic infarct was suggested by ultrasonography and confirmed by MRI. No splenic abscess developed and this was correlated to a rapid improvement of the clinical state following an antibiotic treatment only. The authors discuss the role of sonography and MR in the etiologic diagnosis of splenic involvement in patients suffering from bacterial endocarditis.

Child↗
PubMedDate not supplied

A comparative pilot-scale study of the performance of conventional activated sludge and membrane bioreactors under limiting operating conditions.

The behavior of the conventional activated-sludge (CAS) process was compared to that of the membrane bioreactor (MBR) process under limiting operating conditions; that is, at a low solids retention time (SRT) and hydraulic residence time (HRT). The SRT was varied from 2 to 7 days, and the HRT ranged from 5 to 18 hours. The comparison was carried out in terms of nitrification and denitrification kinetics and in terms of the carbon and nitrogen removal performance of these processes. The study involved two pilot-scale units: a CAS unit with a 9-m3 aeration tank and a 225-L MBR. Both of these units were installed and run under real process conditions at a wastewater treatment plant in Evry, France. In the case of the MBR process, the specific nitrification rates, rN, and the specific denitrification rates, rDN, increased as SRT was reduced from 6.5 days to 2 days. This trend was reversed and the rN and rDN decreased only when the HRT was reduced to 5 hours. A similar behavior was observed in the case of the CAS process, although rN and rDN increased only when the SRT was reduced to as low as 4 days; below this value, the rates dropped considerably. It seems that the presence of the membrane renders the MBR more robust by preventing the washout of nitrifiers at low SRT and HRT. Besides the structure and size distribution of the MBR, flocs are more favorable to intraparticle mass transfer than those of the CAS process and could explain the higher nitrification kinetics observed with the MBR process. In all cases, the carbon and nitrogen removal performance of the MBR process was better than that of the CAS system.

Biomass↗