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Biomedical subjects

C Gasser

Publications and source records attributed to C Gasser.

16 recordsLinked to original sources
PubMed1989

Steroids in rhinoplasty.

A prospective double-blind randomized pilot study was performed to test the benefits of steroids versus placebo in controlling edema and ecchymosis in rhinoplasty within the immediate postoperative period. Thirty consecutive patients who underwent rhinoplasty with osteotomies were entered into the study. Sixteen patients received 10 mg of intravenous dexamethasone before the procedure and 14 patients received placebo. All rhinoplasties were performed by residents under the supervision of staff otolaryngologists. A 4-point scale was used to assess the extent of periorbital edema and ecchymosis at 24 hours postoperatively. A one-time bolus of 10 mg of dexamethasone was beneficial in decreasing edema and ecchymosis in rhinoplasty. This benefit was demonstrated statistically (p less than .005). No complications were attributed to the administration of dexamethasone.

Adolescent↗
PubMed1980

Long-term survival (cures) in childhood acute leukemia. Follow-up of nine cases of acute lymphatic leukemia and two of acute myelogenous leukemia with complete remission lasting more than 10 years, three of them with normal progeny.

11 children, aged between 18 months and 14 years, suffering from acute leukemia showed extremely long-term survival lasting 10-28 years, at an average of 18 years. 9 cases had acute lymphatic leukemia of the low risk group (apart from their age). 2 girls had acute myelogenous leukemia of the promyelocytic type, 1 of them belonging to the high risk group. Treatment was given for 2-10 years, at an average of 5 years, mostly in the form of modified 'monotherapy'. Total therapy, CNS prophylaxis (irradiation and methotrexate intrathecally) was not employed. The children were mostly controlled as outpatients to avoid the danger of hospital infections and to give them a better psychological ambiance. 3 grown-up patients are parents of altogether 6 children, which proves the possibility of normal progeny. The description of these exceptional cases, however, should not lead to the abolition of the present, very promising, intensive therapy with a high percentage of 5-year survivals.

Adolescent↗
PubMed1971

Immunological relationships among lactic dehydrogenases in the genera Lactobacillus and Leuconostoc.

Antisera were prepared against pure nicotinamide adenine dinucleotide-dependent d-lactic dehydrogenases of Lactobacillus leichmannii, L. jensenii, and L. fermenti. When tested against these three antisera, crude extracts of almost all species of Lactobacillus containing a d-lactic dehydrogenase give cross-reactions. Extensive pairwise comparisons between cross-reacting crude extracts by double diffusion experiments permit the recognition of groups of identical antigenic specificity among the lactic dehydrogenases of the various nomenspecies of Lactobacillus. The same groups are revealed by each of the three antisera. By analyses of spur formation, the groups of identical antigenic specificity can be arranged in order of decreasing similarity to the homologous d-lactic dehydrogenase used as the reference point. From the combined results obtained with the three antisera, a map of the antigenic relationships among the d-lactic dehydrogenases of lactobacilli can be constructed. Microcomplement fixation experiments with two of the three anti-d-lactic dehydrogenases antisera support the conclusions drawn from double diffusion experiments and provide a quantitative estimation of the antigenic relationships among the various d-lactic dehydrogenases. An antiserum was also prepared against the pure l-lactic dehydrogenase of L. acidophilus group III. It cross-reacts with extracts of almost all lactobacilli containing an l-lactic dehydrogenase. With respect to species that contain both d- and l-lactic dehydrogenases, this antiserum reveals the same groups of identical antigenic specificity as do the antisera directed against d-lactic dehydrogenases. Other than the genus Lactobacillus, only extracts of Leuconostoc cross-react with anti-d-lactic dehydrogenase. No extrageneric cross-reactions were obtained with the anti-l-lactic dehydrogenase.

Animals↗
PubMed1970

Comparative immunological studies of two Pseudomonas enzymes.

Crystalline preparations of muconate lactonizing enzyme and muconolactone isomerase, two inducible enzymes that catalyze successive steps in the catechol branch of the beta-ketoadipate pathway, were used to prepare antisera. Both enzymes were isolated from a strain of Pseudomonas putida biotype A. The antisera did not cross-react with enzymes of the same bacterial strain that catalyze the chemically analogous steps in the protocatechuate branch of the beta-ketoadipate pathway, carboxymuconate lactonizing enzyme and carboxymuconolactone decarboxylase. The antisera gave heterologous cross-reactions of varying intensities with the muconate lactonizing enzymes and muconolactone isomerases of P. putida biotype B, P. aeruginosa, P. stutzeri, and all biotypes of P. fluorescens, but did not cross-react with the isofunctional enzymes of P. acidovorans, of P. multivorans, and of two bacterial species that belong to other genera. The evolutionary and taxonomic implications of the findings are discussed.

Animals↗