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Biomedical subjects

C Gemzell

Publications and source records attributed to C Gemzell.

At least 19 recordsLinked to original sources
PubMed1982

Ectopic pregnancy following treatment with human gonadotropins.

After treatment with human gonadotropins, 289 anovulatory women with apparently normal fallopian tubes became pregnant 379 times. Ten ectopic pregnancies in nine women were diagnosed, for an incidence of 2.7% of all conceptions. All the ectopic pregnancies were found in the fallopian tubes. Four patients had also an intrauterine pregnancy. Five of the patients showed ovarian overstimulation, and hormonal modifications at the time of ovulation might explain the high incidence of tubal gestation.

Abortion, Induced↗
PubMed1982

Neocept: a simple, sensitive urine test of early pregnancy in women undergoing ovulation induction.

Fifty-five anovulatory women undergoing hMG-hCG treatment in order to become pregnant had daily first morning urine specimens and blood samples drawn, starting from the 11th postovulatory day. The urine was tested with Neocept and the blood with a radioreceptor assay or a radioimmunoassay for beta-subunits of hCG. Twenty-two of the women became pregnant. The pregnancies were detected by Neocept within a span of 12 to 19 days after ovulation. On the day of the first positive urine test, the mean serum concentration of the beta-subunit of hCG in 17 women was 103 +/- 10.1 (S.D.) mIU/ml (range, 39 to 200), and the mean serum level of 5 women tested by the radioreceptor assay was 206.5 +/- 6.5 mIU/ml (range, 170 to 220). Of 8 women with a positive urine test on day 15 or sooner, only 1 aborted, whereas 7 of the 14 women who were found thereafter to be positive aborted. None of the treated women who ovulated but did not conceive had a positive urine test. Of these women there were nine with a prolonged luteal phase (18 to 22 days).

Chorionic Gonadotropin↗
PubMed1980

The use of human gonadotropins for the induction of ovulation in women with polycystic ovarian disease.

During the years 1974 to 1977, a total of 77 treatment cycles of human menopausal gonadotropin (hMG)-human chorionic gonadotropin (hCG) were administered to 41 infertile patients with polycystic ovarian disease who failed to conceive on clomiphene. Twenty-seven patients (65.9%) conceived, two of them twice, making twenty-nine pregnancies. The abortion rate was 24.1% and the multiple pregnancy rate was 36.3%. Of the 77 treatment cycles, 7.8% were complicated by mild hyperstimulation and 3.9% by severe hyperstimulation. In six treatment cycles (7.8%), ovulation occurred spontaneously prior to the hCG injection. hMG-hCG is an additional safe and effective, nonsurgical treatment for women with polycystic ovarian disease who have failed to respond to clomiphene therapy. The reaction to exogenous gonadotropins is unpredictable and probably depends on the stage of follicular development prior to the stimulation. Therefore, daily estrogen determinations from the 1st day of treatment are mandatory in order to avoid hyperstimulation and/or multiple births.

Adult↗
PubMed1979

Pregnancy following treatment with human gonadotropins in primary unexplained infertility.

Six patients with primary unexplained infertility of 2 to 9 years duration, and who failed to conceive after repeated trials of clomiphene treatment, were treated with human gonadotropins; 3 of them became pregnant following one or two courses of treatment. Three patients failed to conceive in spite of 3 courses of human gonadotropins, 2 of them had high titers of sperm-agglutinating antibodies found in their sera, which may explain their infertility. None of the 13 treatments resulted in hyperstimulation syndrome or multiple births. This preliminary result seems encouraging but awaits further study.

Adult↗
PubMed1977

Sperm-freezing and donor insemination.

A comparison between freezing of human sperm using glycerol or glycerol egg-yolk citrate is presented. Freezing was performed with a gradual lowering of the temperature using alchol-liquid nitrogen or by immersion into liquid nitrogen. Great variations were observed within the same donor sperm sample when the sperm was frozen according to different techniques and marked post-thaw, motility variations were also found between spermatozoa from different donors. No statistically significant differences were found in the number of pregnancies obtained following inseminations with sperm frozen according to the two methods.

Citrates↗
PubMed1975

Human pituitary luteinizing hormone. Isolation and characterization of four glycoproteins with luteinizing activity.

Two major and two minor components of human luteinizing hormone (lutropin) were isolated from whole frozen pituitaries by a procedure involving extraction of homogenized pituitaries, (NH4)2SO4 fractionation, chromatography on DEAE-cellulose, Sephadex G-100, and SE-Sephadex C-50 and electrophoresis in polyacrylamide gel. The isolation procedure was monitored by both bioassays and radioimmunoassays. Contamination of the final products by other pituitary hormone activities was very low. The four lutropin components were all homogeneous by polyacrylamide gel electrophoresis (a sieving medium) and by free zone electrophoresis (a non-sieving medium). No heterogeneity was observed when the components were studied in the ultracentrifuge by sedimentation-equilibrium technique. The molecular weights of the components were in the range of 34 000-40 000. Sedimentation velocity experiments with the two major components revealed in each case one boundary with S20,W values of 3.2 S and 3.5 S. Further evidence for the homogeneity of the components was the observation of only one precipitin line for each component upon immunodiffusion against a rabbit anti-human lutropin serum. Amino acid and carbohydrate analyses indicated close similarity among the four components. From the analysis data the molecular weights of the components were calculated to be 31 000-33 000.

Amino Acids↗
PubMed1975

Induction of ovulation in infertile women with pituitary tumors.

Four infertile women with pituitary adenoma were treated with human pituitary gonadotropins (HPG) in order to enable them to become pregnant. During pregnancy they contracted headache, bitemporal visual field defects, or impaired visual acuity. One woman was operated upon in the second trimester; the other three, as the symptoms were relatively moderate and no risk of permanent damage to the optic tract existed, went to term. After operation or delivery the symptoms disappeared.

Adenoma↗
PubMed1975

Induction of ovulation.

Ovulation has been induced by clomiphene citrate and human gonadotropins in infertile women. Clomiphene should be the first choice in anovulatory women with active ovaries as indicated by basic levels of estrogens in blood or urine, in women with post-pill amenorrhea even if their ovaries are quiescent and in women with functional abnormalities of the hypothalamus or pituitary. Human gonadotrophins should be used as a second alternative when clomiphene fails. It should also be used as a first choice in women with primary amenorrhea and quiescent ovaries and in women with gross anatomical changes in the pituitary or hypothalamus. If no result is obtained after two courses of gonadotropic therapy, further treatment should be reconsidered and the infertile couple reinvestigated.

Adult↗