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Biomedical subjects

C Goldie

Publications and source records attributed to C Goldie.

4 recordsLinked to original sources
PubMed1986

Effect of carbamazepine on psychomotor performance in näive subjects.

The effect of a single dose of carbamazepine (CBZ), 10 mg kg-1, on a battery of simple psychomotor tests was investigated in 12 healthy subjects (6 male, 6 female) in a balanced randomised double blind placebo controlled cross-over study. Psychomotor testing and blood sampling for total and free plasma CBZ, and CBZ 10, 11 epoxide concentration were performed at 10, 12, 14, 16, 18 and 34 h after oral dosing (23.00 h the previous evening). CBZ impaired i) critical flicker fusion threshold frequency at all time points up to 18 h (p less than 0.005); ii) total choice reaction time at 10 h (p less than 0.005) and 18 h (p less than 0.008); iii) card sorting at 14 h (p less than 0.001). No significant effect on finger tapping was noted. Subjects adjudged themselves more sedated on CBZ as compared to placebo at 12, 14 and 16 h (p less than 0.008). Plasma total and free CBZ concentrations (mean +/- SD) peaked at 10 h (8.8 +/- 0.2 mg 1-1) and 16 h (1.88 +/- 0.3 mg 1-1) after dosing respectively. CBZ 10, 11 epoxide values were all less than 10% of total CBZ concentrations and, therefore, were unlikely to contribute to the pharmacodynamic effect. Total choice reaction time was significantly more impaired in females (p less than 0.05) but no sex difference occurred with the other tests or CBZ concentrations at any time point. No significant correlations were found between individual total or free CBZ concentrations and corresponding test performances at each time point.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

The effect of retirement on somatic complaints.

This study investigated whether the level of somatic complaint increases as men make the supposedly stressful passage from work to retirement. For 171 retirees, pre- to post-retirement changes in the sum of selected somatic complaints from the Cornell Medical Index were compared with changes over a comparable time interval (3-5 yr) in 386 age peers who continued to work. Although there was slightly increased frequency of somatic complaint over time, eventual retirees did not differ from continuing workers in the amount and direction of change. Among retirees only, change from pre-retirement complaint levels did not vary by retirement age, length of time retired, part-time work in retirement, former occupational level or marital status, nor was it affected by the circumstance of compulsory retirement. These results, which are based on a continuous measure of health status, confirm previous findings from categorical data which conclude that retirement's effect on health is negligible.

Age Factors↗
PubMed1982

Retrospective analysis in smoking cessation research.

The use of retrospective data in smoking research represents possible sources of bias resulting from: (1) baseline incomparability of current, former, and non-smokers, (2) instability of parameters under investigation, and (3) difficulties in recall. A self-report measure of smoking motives was employed in a longitudinal design to examine bias associated with retrospective data analysis. Thirty-six pairs of former smokers and recidivists (smokers who had tried to quit) were matched on age and amount smoked. Although initial responses for both groups were comparable, former smokers were significantly higher on smoking motive factors after quitting compared to recidivists who stayed essentially the same. The findings suggest that mean differences in smoking motives between recidivists and former smokers assessed cross-sectionally may not accurately reflect the magnitude of the differences that existed when both groups were smoking.

Adult↗