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Biomedical subjects

C Grose

Publications and source records attributed to C Grose.

125 records · Page 7Linked to original sources
PubMed1976

Guillain-Barré syndrome following administration of live measles vaccine.

In a 19 month old girl and a 10 month old girl the Guillain-Barre syndrome developed within a week after they received, respectively, live measles-rubella vaccine and live measles vaccine. The older child was immune to the rubella at the time of vaccination, but both girls demonstrated a primary measles antibody response. Serum obtained during the acute and convalescent stages from the younger child was tested for antibodies against the herpes viruses (herpes simplex, Epstein-Barr virus, cytomegalovirus and varicella-zoster) and found to be negative.

Antibodies, Viral↗
PubMed1976

Characterization of an enterovirus associated with acute infectious lymphocytosis.

An enterovirus (EVU-16) previously isolated from children with acute infectious lymphocytosis has been further characterized. The EVU-16 virus sediments as a 135S particle in sucrose gradients, has a density of 1-335 g/ml in CsCl, contains 4 polypeptides and has a single stranded RNA genome sedimenting at 35S. These structural features as well as the presence of a virus-related particle, the procapsid, are similar to those of other enteroviruses. However, the largest polypeptide of EVU-16 is 49000 daltons, which is considerably larger than the corresponding polypeptide from poliovirus; the sizes of the other three viral polypeptides were similar in both viruses. Attempts to induce lymphocytosis by the inoculation of EVU-16 into various animals, including immunologically aberrant 'nude' mice, were unsuccessful.

Cell Line↗
PubMed1975

Primary Epstein-Barr-virus infections in acute neurologic diseases.

Infectious mononucleosis has been associated with Guillain--Barré syndrome, Bell's palsy, meningoencephalitis and transverse myelitis. Since it is not known that many children with infectious mononucleosis do not develop heterophil antibodies, we looked for evidence of current or recent Epstein-Barr virus infection in young patients with these neurologic diseases by using serodiagnostic procedures for detection and titration of antibodies to various antigens related to Epstein-Barr virus. Seven of 24 cases with Guillain-Barre syndrome and three of 16 with facial palsy were definitely associated with primary infection with Epstein-Barr virus as were two cases each of the other two neurologic diseases. Only one of these patients had obvious clinical infectious mononucleosis, and only a few demonstrated heterophil agglutinins. It is evident that the virus must be considered in the diagnosis of various acute neurologic diseases affecting children and young adults, even in the absence of heterophil-antibody response or other signs of infectious mononucleosis.

Acute Disease↗
PubMedDate not supplied

Glycoproteins of varicella-zoster virus and their herpes simplex virus homologs.

This report describes the glycoproteins of varicella-zoster virus (VZV) and their role as immunogens and discusses the relevance of studies of VZV to the selection of a glycoprotein subunit herpes simplex virus (HSV) vaccine. HSV types 1 and 2 and VZV are alpha-herpesviruses, which are characterized by common biologic features such as a relatively short replication cycle and a latent state, often in neurologic tissues. The three viruses also conserve several glycoprotein genes, including gB, gC, gE, gH, and gI. The known properties of the VZV glycoproteins closely resemble those of their homologous HSV counterparts and may provide further insight into biologic functions of the immunogens. In particular, VZV glycoproteins gpII and gpIII closely resemble their HSV homologs gB and gH in that all four harbor complement-independent neutralization epitopes.

Glycoproteins↗
PubMedDate not supplied

Complete spectrum of the varicella congenital defects syndrome in 5-year-old child.

Chickenpox in the pregnant woman occasionally leads to infection and teratogenesis of the early to midgestational embryo. We describe the developmental assessment and clinical management of a 5-year-old girl with classic varicella congenital defects syndrome. This patient is unique with respect to (1) a generally favorable outcome in spite of the severity of her anomalies involving the eyes, limbs and skin, (2) a completely normal evaluation of her immunologic status and (3) a serologically documented herpes zoster infection at age 41 months.

Abnormalities, Multiple↗