PubMed Health⌕ Search

Biomedical subjects

C Grushkin

Publications and source records attributed to C Grushkin.

3 recordsLinked to original sources

Use of a subclavian venous catheter for short- and long-term hemodialysis in children.

Vascular access for hemodialysis in children poses problems not encountered in adults because of the small size of the vessels available. The increasing use of peritoneal dialysis has created a large number of patients who need prompt access for hemodialysis for days to weeks during episodes of peritonitis. There are also occasional patients who have exhausted available fistula sites and still require hemodialysis. To address these problems, we designed a series of catheters for insertion in the subclavian vein. The catheters are stiffer than the Hickman type catheter to allow for higher flow rates without collapse. Seventy-five catheters were implanted in 58 patients with a mean age of 14 years. Twelve catheters were inserted in ten children for long-term (over 3 months) access; they have been in place for a mean of 259 days and used for a mean of 64 dialyses. In two children, the catheter has been the sole site for hemodialysis for over a year. Fifty-eight catheters were implanted in 43 patients for short-term hemodialysis. They were in place for a mean of 29 days and used for a mean of 13 dialyses. The major complications encountered were clotting of the catheter and migration out of position. Four catheters were removed because of infection. These new catheters provide effective hemodialysis for children as small as 7 kg with an acceptable morbidity rate and may be used for extended periods of time if necessary.

Adolescent↗

Hyperuricemia in diarrheal dehydration.

Serum uric acid levels were measured in 133 dehydrated patients admitted with diarrhea. Elevated levels were found in 80% of the patients; the highest was 38 mg/dL. Serum uric acid was correlated with serum urea nitrogen and the levels tended to be higher in patients with hypernatremia. The serum uric acid levels returned toward normal with rehydration, and no specific therapy was necessary.

Blood Urea Nitrogen↗