[Chronic pancreatitis. Modern surgical views. Clinical contribution].
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Biomedical subjects
Publications and source records attributed to C Guerrera.
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The authors report their experience concerning 26 cases of gastric stump carcinoma after gastric resection for benign pathology, observed in about 12 years. The incidence of such disease is 9,2% as regards the gastric neoplastic pathology and 5,2% as regards the benign ulcerous pathology, observed in the same period of time. The removal of the tumour was performed in 18 cases (69,2%), in spite of the stage, in most cases advanced, of the disease. In 7 cases (38,8%) the operation was extended to other organs. In 5 cases (27,7%) the removal was performed in spite of the presence of liver metastases. The survival amounts to 3 (16,6%) patients after 2, 4,5 and 5 years, one of whom suffers from liver metastases. In spite of the better knowledge of the histologic modifications and the phenomena caused by the biliopancreatic rebux and gastric hypochlorhydria, the etiopathogenesis of that disease is still unknown; the prognosis remains still unfavourable, due to the diagnostical delay and the particular aggressiveness of the neoplasm. Therefore, the Authors confirm the necessity for a precocious diagnosis, which only is suitable to improve the immediate and remote results.
This paper presents a case of malignant fibrous histiocytoma localized in the sigmoid colon with multiple metastases in the right lobe of the liver and describes the pathological and microscopic aspects, clinical course and characteristics. The primary localization in the sigmoid colon is extremely rare, this being only the second case reported.
The Authors, in the light of their experience, study some technical aspects in the use of circular stapling devices (SPTU-EEA). After paying attention to the risks involved in the employment of such instruments, they explain the precautions they consider necessary to prevent the most common complications. As a conclusion, they confirm the safety of stapling devices, provided they are used with skilfulness and caution.
A series of 65 patients with acute pancreatitis is analyzed with special regard to ethiopatogenesis and therapy. In several cases (68%) surgery has been performed with good results. Results are discussed and confronted with bibliographic report. The main problem, according to Authors, is to diagnose the real cause of pancreatitis for every patient, so that is possible to choose the appropriate may of treatment.
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The authors review the indications of their 146 cases of supraduodenal choledochoduodenostomy (SDC) from 1970 to 1977. The conditions for which the procedure was carried out were dilatation of the choledochus (100%), multiple calculosis (83%), and primitive or secondary stenosing odditis (17%). After a detailed discussion of these indications, the authors report their immediate and long-term results, which were good in 96% of the patients. In the matter of surgical technic the authors give preference to laterolateral SDC, stressing that effective anastomosis requires a choledochal diameter of at least 10 or 12 mm. In good accord with data published from other sources, the authors' data suggest further restriction of direct procedures (in view of the associated risk of acute pancreatitis) in favor of SDC. The authors also review the objections to, and complications of, this surgical procedure, and conclude that these are never so important as to discourage the procedure when definitely indicated.
After outlining and discussing the etiology and pathophysiology of the postcholecystectomy syndrome, the authors describe their own series of 35 cases, therapeutic policies, and results obtained. In the discussion they suggest that the so-called cystic stump syndrome has probably been overplayed, since in the authors' own series of cases there was a high incidence of associated pathology.
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Diet therapy is an essential instrument in the prevention and treatment of non-insulin-dependent diabetes mellitus and its complications. Nutritional advice allow to modify the mechanisms underlying deranged carbohydrate metabolism, control disease evolution and/or retard pharmacological treatment. We describe the main dietetic factors that can influence this widespread metabolic disorder.
Malnutrition is prevalent in patients with advanced chronic liver disease and may be associated with a worse prognosis. Treatments often include many dietary restrictions (regarding fluids, sodium and proteins), which may further limit energy intake in addition to other factors limiting food intake (e.g. anorexia, encefalopathy). Guidelines for an optimal diet therapy in patients with different liver diseases, above all in presence of encefalopathy, are briefly reported.
The above study was intended to assess the efficacy of nicardipine in mild to moderate essential arterial hypertension and to check whether there are medium term changes in kidney function and urinary excretion of electrolytes in the course of nicardipine treatment. Twenty patients with mild to moderate essential arterial hypertension were treated daily with 40-80 mg doses of slow-release nicardipine after a wash-out period. Systolic and diastolic blood pressure was measured with traditional sphygmomanometer on entry and after 4, 8, and 12 weeks' treatment. Also, on entry and at conclusion of the study, the following parameters were measured: plasma renin activity, creatinine clearance, 24-hour urinary excretion of Na, K, Ca, and aldosterone. Nicardipine treatment was well tolerated and no significant changes of heart rate, creatinine clearance and urinary excretion of Na, K, Ca and aldosterone were observed after 12 weeks' treatment. The efficacy of nicardipine for the management of mild to moderate hypertension was thus confirmed. The absence of a natriuretic effect after 12 weeks' treatment goes to show that any diuretic action of the drug is irrelevant to its therapeutic effect which appears to be due mainly to its vasodilatory action.
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