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Biomedical subjects

C Guillausseau

Publications and source records attributed to C Guillausseau.

11 recordsLinked to original sources
PubMed1988

[Endocrine polyadenomatosis of 2a type (MEN 2a). Clinical and genetic study of a family].

In a large kindred with multiple endocrine neoplasia type 2a (MEN 2a) (137 members, 5 generations), bilateral thyroid medullary carcinoma was found in all affected members. Pheochromocytoma was present in 59% of the cases, and was responsible at least for 4 out the 5 deaths related to MEN 2a. Hyperparathyroidism was less frequent (41%). Family screening leads to a reduction in age for diagnosis and to an improvement in the prevalence of complete healing after surgery. Linkage between HLA loci and a dominant gene for MEN 2a was investigated in this kindred. Lod scores for recombination fraction were all negative (-0.47 for a recombination fraction of 0.05). These results comfort the lack of linkage between MEN 2a and the HLA complex.

Adolescent↗
PubMed1986

Subcutaneous insulin resistance syndrome. Effects of long-term aprotinin therapy.

The case of a young Type 1 diabetic patient with subcutaneous insulin resistance, causing recurrent ketoacidosis, is reported. Intramuscular and intravenous insulin administration remained effective. After failure of CSII, continuous intramuscular insulin infusion was used during 10 months followed by a combination of insulin and a protease inhibitor aprotinin, with good results. After 18 months' aprotinin therapy, subcutaneous insulin resistance disappeared. The subcutaneous insulin resistance syndrome and the role of aprotinin are discussed.

Adolescent↗
PubMed1985

Hemostasis disorders in diabetes mellitus.

Hemostasis disorders are involved in diabetic micro and macroangiopathy. Platelet hyperactivity is related at least in part to an imbalance between thromboxane A2 and prostacyclin. Both hyper and hypoglycemia result in platelet activation.

Animals↗
PubMed1985

[Value of the detection of antithyroid antibodies in thyroid pathology].

Antithyroid microsomal hemagglutination antibody (MCHA) and antithyroglobulin hemagglutination antibody (TGHA) were measured in 629 patients with thyroid disease and 100 controls. Thyroid antibodies were present in 4% of control patients, only in women and at low titer. Thyroid antibodies prevalence was 97% in autoimmune thyroiditis (MCHA: 93%; TGHA: 53%), was 55% in Graves disease before treatment (MCHA: 46%; TGHA: 33%) and 90% in the first year following 131I therapy. Antibodies prevalence was 57% in myxoedema (MCHA: 52%; TGHA: 25%). In patients with iodine overload, antibodies prevalence was 29% in euthyroid patients, 25% in iodine-induced hyperthyroidism and 55% in iodine-induced hypothyroidism. Thyroid antibodies detection should be systematically performed in the routine evaluation of any thyroid disorder. Because of discrepancies between TGHA and MCHA positivity, their simultaneous detection should be performed.

Adenoma↗
PubMed1979

[The provoked-hyperglycemia test. Follow-up after two years of 94 cases with doubtful results (author's transl)].

A retrospective study of 94 patients, who had had doubtful results in the oral provoked-hyperglycemia test, was made after an average period of 23 months. It was found that 26 patients were diabetic, 34 were normal and 34 were still doubtful. The factors which influence the evolution of these cases are the sex, a family history of diabetes (before 60 years of age), and the return to normal weight of obese patients.

Adolescent↗
PubMedDate not supplied

[Paradoxical effects of iodine overload on thyroid function].

Any chronic iodine overload resulting from long term ingestion of a medication or the administration of a non-resorbable contrast medium, may result in a goitre with or without hypothyroidism, and in particular in patients with a past history of thyroid disease. By contrast, the administration of iodine is no longer indicated in the treatment of enedmic goitres since the hypothesis of an iodine deficiency in the pathogenesis of such goitres may be excluded in most countries, and in particular western countries, and the risk of the development of thyrotoxicosis in such patients is not negligeable. It would thus be desirable that iodine no longer be used in the composition of medications when its presence is not indispensalbe and where, furthermore, it may contribute to developement of an increasingly disturbing iatrogenic complication.

Aged↗