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Biomedical subjects

C Guillen

Publications and source records attributed to C Guillen.

26 records · Page 2Linked to original sources

Multicentric reticulohistiocytosis.

A case of multicentric reticulohistiocytosis in a 49-year-old man associated with polymyositis is presented. The clinical features along with the light and electron microscopic studies are commented. Partial improvement of the skin lesions was achieved after treatment with azathioprine but the patient's general condition remained unchanged.

Arthritis↗

Videomicroscopy of venular malformations (port-wine stain type): prediction of response to pulsed dye laser.

Videomicroscopy has been found to be useful in determining the depth of ectasia of vascular malformations. Different patterns that hypothetically could predict the response of a vascular malformation to pulsed dye laser have been described. Our purpose was to determine if the dermoscopy pattern was able to predict the response to pulsed dye laser therapy and if it was independent of other known clinical variables. Thirty-three consecutive children presenting for evaluation or treatment of vascular malformations underwent videomicroscopy previous to pulsed dye laser therapy. Sixty-nine representative areas were evaluated before and after laser therapy. Other clinical factors, including location of the malformation, the patient's age and sex, and previous therapy, were also included in the analysis. We found that the dermoscopy pattern was differently distributed depending on the anatomic area. A superficial pattern was not present in the centrofacial area. An undefined pattern was most often present when a previously treated area was imaged. A superficial pattern independently predicted a good response to laser. The location of the lesion was another independent factor influencing the outcome. A new pattern consisting of a pale circular area surrounding a central brownish dot is described as negatively influencing the response to laser therapy. We concluded that videomicroscopy is a good tool for assessing which vascular malformations can be adequately treated with laser therapy, although other anatomic factors can influence the response. Videomicroscopy is particularly helpful in deciding when to end the treatment because it objectively shows when no further response can be expected, and is helpful for demonstrating this to patients and their parents.

Adolescent↗

[Emergency endoscopy in upper digestive hemorrhage].

In our hospital the incidence of upper digestive hemorhage [UDH] is greater after the 4th decade of age and predominantes in the male sex. The patients' clinical data was important in the diagnosis of the lesion. In 63% of our cases a close relation was found between the previous intake of substances considered ulcerogenous and the hemorrhagic episode, as well as the presence of stress situations. In our experiences the causes of UDH in order of their frequency are: 1. Acute lesions of the gastric mucosa. 2. Duodenal ulcer. 3. Gastric ulcer. 4. Stomal ulcer. 5. Bleeding esophagitis. 6. Others. The digestive hemorrhages of undetermined caused corresponded to 2,33% of the cases. The early diagnosis of UDH by means of emergency endoscope was of great value in the therapeutic handling of patients.

Adult↗

Cyclosporine A shows immunosuppressor activity on T lymphocytes from the peripheral blood and synovial fluid of patients with autoimmune arthritis.

OBJECTIVE: This work studies the effects of Cyclosporine A (CsA) upon the activation and proliferation of mononuclear cells (MNC) from the peripheral blood (PB) of patients with chronic autoimmune arthritis and from healthy controls, and from the synovial fluid (SF) of patients. METHODS: In vitro studies of activation, proliferation, mRNA expression and lymphokine production were carried out. RESULTS: We found in the PB and SF MNCs from patients with autoimmune arthritis that CsA inhibits the proliferative response, activation antigen expression, IL-2 mRNA expression and IL-2 production induced by polyclonal mitogens in a dose dependent manner. CONCLUSION: CsA blocks lymphocyte activation in PB and SF MNCs from patients with autoimmune arthritis.

Antigens↗