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Biomedical subjects

C Gutiérrez-Samperio

Publications and source records attributed to C Gutiérrez-Samperio.

5 recordsLinked to original sources
PubMed1989

Influence of D-Trp-6-LH-RH on the survival time in patients with advanced pancreatic cancer.

Carcinoma of the exocrine pancreas seems to be sex-hormone sensitive. Administration of agonistic analogs of luteinizing hormone--releasing hormone (LH-RH) creates a state of sex-hormone deficiency. Therapy with D-Trp-6-LH-RH was evaluated in 17 patients with unresectable and biopsy-proven adenocarcinoma of the pancreas (stage IV). Nine patients were male and 8 female, and the median age at diagnosis was 60 years. The majority of patients underwent a gastro-intestinal and biliary bypass. The therapy with D-Trp-6-LH-RH was started 3-31 days after bypass surgery. The analog was given at the dose of 1 mg/day subcutaneously for the first 7 days. Subsequently, the dose was reduced to 100 micrograms/day. One month after the start of the therapy the gonadotropin levels were in subnormal range. This therapy led to clinical improvement, better quality of life and an increase in survival time. The median survival time for all the groups was 7.2 months (men 7.4 months and women 6.9 months). LH-RH agonists appear to decrease pancreatic cancer growth by eliminating the stimulatory effect of sex steroids, and by direct effects on tumors. Further improvement in the clinical response in patients with inoperable pancreatic carcinoma might be possibly obtained by the combination of LH--RH agonists with modern somatostatin analogs.

Adenocarcinoma↗
PubMedDate not supplied

[The surgical patient in critical state. Progress in the diagnostic-therapeutic process].

Bases on advances in scientific knowledge, we have reviewed the circumstances under which patients recommended for surgery may enter a critical state pre, trans, and post-operatory period and the physiopathological changes that these patients undergo: hypovolemia; systemic inflammatory response syndrome; infection; sepsis; septic shock; and multiple organic failure. We have analyzed the utility of advantages in diagnostic procedures, with emphasis on non-invasive methods, the dosage of inflammation intermediaries, and the use of prognostic indices. We have also looked into effective circulation volume replenishment, organ function failure, the rational application of vasoactive amines, antibiotics, and monoclonal antibodies, as well as surgery with septic focus elimination, and pre- and post-operation nutritional support.

Critical Illness↗
PubMedDate not supplied

[Bioethics in the face of death].

We review death, thanatology and bioethics concepts and precepts, the value scale and hierarchization; the changes in death vision according to culture, religion and hierarchy, changes in perception of, according to culture, religion and mores in different communities and times, as well with scientific and technological advances. We analyzed patient's reactions to death, and the reactions of people close to them. We describe and analyze the principal bioethical dilemmas associated with death: therapeutic overkill or dysthanasia, passive and active euthanasia, assisted suicide, orthothanasia, and organ transplants. We discuss the relationship between death and science, bioethics and thanatology, as a necessary discipline today.

Attitude to Death↗