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Biomedical subjects

C Guy

Publications and source records attributed to C Guy.

At least 55 records · Page 3Linked to original sources
PubMed1995

[Acquired myelodysplastic syndromes after treatment of melanoma with fotemustine and dacarbazine].

INTRODUCTION: Secondary myelodysplasia after antimitotic therapy is a rare complication usually observed with alkylating agents. The condition usually progresses to acute leukaemia with very poor short term prognosis. CASE REPORT: We report the cases of 2 women who developed myelodysplasia 2 and 9 months after treatment associating dacarbazine and fotemustine for visceral metastases of a malignant melanoma. DISCUSSION: The frequency of these rare complications is probably underestimated because of the rapid unfavourable outcome of metastatic malignant melanoma. We were unable to determine whether dacarbazine, fotemustine or their combination was incriminated in this complication. Risk could be reduced by carefully determining the cumulative doses of these antimitotics.

Aged↗
PubMed1994

[Porphyria cutanea tarda induced by HMG CoA reductase inhibitors: simvastatin, pravastatin].

INTRODUCTION: Based on experimental data, HMG CoA reductase inhibitors are theoretically contraindicated in patients with porphyria. These new cholesterol lowering drugs are increasingly being prescribed. We report the first case of drug-related porphyria cutanea tarda due to HMG CoA reductase inhibitors. CASE REPORT: Porphyria cutanea tarda was diagnosed in a patient with chronic alcoholism 18 months after beginning a treatment with simvastatin followed by pravastatin. These drugs were given under different trade names and reintroduced successively leading to acute episodes. Total withdrawal of HMG CoA reductase inhibitors was followed by clinical normalization. COMMENTS: This case confirmed the theoretical contraindication for the use of HMG CoA reductase inhibitors in patients with porphyria. The risk of revealing porphyria with this type of cholesterol lowering drugs is emphasized. Since these drugs are used very frequently, similar cases may well be reported soon.

Aged↗
PubMed1993

Electronic three-dimensional imaging of intestinal endoscopy.

Endoscopists, especially those investigating the colon, need to know where the tip of the instrument is and whether the tube is kinking. A three-dimensional real-time imaging system consisting of sensors, within or taped to the endoscope, to detect weak electric currents in a wire grid below the mattress yields the information needed and should greatly facilitate performance and teaching of endoscopy.

Colonoscopes↗
PubMed1993

[Unexplained chronic diarrhea, apropos of 4 new cases under Cyclo 3 fort and review of the literature].

We report 4 cases of chronic diarrhoea in patients treated with Cylclo 3 fort. This side-effect was not mentioned in the French list of therapeutic drugs until 1992. The diarrhoea was without faeces and without glairy mucus or blood. Symptomatic treatments were totally ineffective. The diarrhoea itself was well tolerated, but 3 patients lost weight, with hypokalaemia in 2 of them, and 1 had regressive acute renal failure. The time elapsed between the first dose of Cyclo 3 fort and the diarrhoea ranged from 1 to 3 months, and it took 5 months to make the aetiological diagnosis. Two patients were hospitalized. Withdrawal of the drug always resulted in cure. One patient taking enemas developed a regressive subocclusion of the bowel. The physiopathological mechanism of this diarrhoea is unknown. These cases are similar to the 5 other cases reported in the literature.

Acute Kidney Injury↗
PubMed1991

The role of serotonin in sexual dysfunction: fluoxetine-associated orgasm dysfunction.

Iatrogenic sexual dysfunction has been associated with many pharmacologic agents. The authors report 6 cases of orgasm dysfunction associated with the use of fluorxetine in 77 depressed outpatients. Fluoxetine is a novel antidepressant known to block the reuptake of serotonin with little effect on other neurotransmitter systems. Because fluoxetine has a specific mechanism of action, it serves as a useful model to hypothesize about potential mechanisms of drug-induced sexual dysfunction. The possible effects of serotonin on central, spinal, and peripheral anatomical areas are discussed in relation to drug-induced sexual dysfunction.

Adult↗
PubMed1990

Localization of a locus for Charcot-Marie-Tooth neuropathy type Ia (CMT1A) to chromosome 17.

Phenotypic data for 71 genetic markers for members of five Caucasian kindreds were tested for linkage with the autosomal dominant mutations causing Charcot-Marie-Tooth (hereditary motor sensory) neuropathy type I, characterized by markedly reduced nerve conduction velocities. Lod score analysis gave no evidence of linkage to the closely linked chromosome 1 loci SPTA1-FY-F5-AT3 and APOA2. In contrast, these mutations were found to map closely (zeta = 10.828, theta = 0.0) to D17S58, an anonymous segment of DNA from 17p11.2-p11.1, and thus define the CMT1A locus. Segregation information data for an inferred recombinant offspring indicated that the CMT1A locus is probably proximal to MYH2, the locus encoding adult skeletal muscle myosin heavy polypeptide 2, which maps to 17p13. Analysis of the lod scores on a per kindred basis gave no evidence of genetic heterogeneity.

Charcot-Marie-Tooth Disease↗
PubMed1978

[Implantation of a bio-artificial insulin distributor in dogs, using islets of Langerhans from different animal species].

In the diabetic dog, the implantation of a bioartificial insulin distributor (Biard) producted a temporary normoglycemia, using islets of Langerhans isolated from dog pancreas and cultured on the outer surface of the hollow fibers (XM 50). In a diabetic dog receiving the Biard using porcine isolated islets, the hyperglycemia was partially corrected during two days. In a diabetic dog due to implantation of human isolated islets the slight rise of insulin and human C-peptide is not accompanied by significant decrease in hyperglycemia. However, in another diabetic dog the Biard implantation of human islets provoked a significant increase of insulin and human C-peptide in the blood, with partial normalisation of hyperglycemia during two days.

Animals↗