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Biomedical subjects

C H BEST

Publications and source records attributed to C H BEST.

At least 19 recordsLinked to original sources
PubMed1962

Some thoughts on the etiology of human diabetes.

A suggested classification of the possible causes of diabetes mellitus is presented, based on the assumption that the disorder is genetically controlled. On the one hand there are factors which produce a failure in the formation, liberation, or action of insulin; on the other hand, there are factors which produce an increased formation, liberation, or action of substances which, in excess, have diabetogenic effects. As well, genetic defects that give rise to diabetes mellitus may involve insulin-dependent reactions or, as a theoretical consideration, be independent of hormonal actions. Final clarification of the physiological mechanisms by which each of the causes produces abnormalities in metabolism offers a challenge for future investigation, as well as elucidation of the primary defect or defects in diabetes mellitus.

Diabetes Mellitus↗
PubMed1958

Kwashiorkor type of fatty liver in primates.

Fatty livers resembling those seen in the early stages of kwashiorkor have been produced in primates. Monkeys were fed, for about 1 year, purified diets free from choline and betaine and low in methionine. Supplementation with choline slightly improved food consumption and gain in weight. Choline prevented the appearance of any stainable lipide in the liver of the control animals. The extent to which the slightly greater intake of protein, including methionine, in the choline-supplemented animals contributed to the prevention of the periportal accumulation of fat in the liver is being determined.

Animals↗