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Biomedical subjects

C H Fang

Publications and source records attributed to C H Fang.

At least 37 records · Page 2Linked to original sources
PubMed1990

Wound contraction following transplantation of microskin autografts with overlaid skin allograft in experimental animals.

The wound contraction associated with a new grafting technique, transplantation of microskin autografts with overlaid skin allograft, was evaluated in a rat model. Male inbred Lewis rats were used as microskin autograft recipients while Buffalo rats were used as allogeneic skin graft donors providing a sheet allograft for overlay. This technique was compared with the use of sheet isografts. Wound contraction was observed for 4 months. The results showed that the application of autologous microskin grafting with allograft overlay was associated with more scar contraction than was the use of a sheet isograft. Maximum contraction to 43 per cent of the original size appeared at 7 weeks postgrafting in the microskin grafting group, while in the sheet isografting group the greatest contraction occurred at 4 weeks postgrafting when it retained 72 per cent of the original size.

Animals↗
PubMed1990

The effect of free radical scavengers on outcome after infection in burned mice.

Thermal injury generates free radicals from various cellular populations, and modulation of free radical activity with scavengers may improve outcome. Balb/c mice were infected with Ps. aeruginosa the day after burn injury and mortality rates observed. Tocopherol was given by gavage daily for 4 days starting 2 days before burn. Survival was improved in the groups receiving 25 and 250 IU/kg compared to control. In other groups, tocopherol was given after burn, but mortality rates were not changed. Treatment with the oxygen radical scavengers ascorbic acid, and a combination of superoxide dismutase and catalase had no effect on mortality. We conclude that ascorbic acid, superoxide dismutase, and catalase do not appear to benefit survival after thermal injury and infection in this murine model. Tocopherol given in high doses of at least 25 IU/kg by gavage preceding injury and continued thereafter for 2 days did improve survival, but this benefit was not seen if tocopherol was not started until after injury.

Animals↗
PubMed1990

[Clinical experience of hemiarthroplasty with Bateman bipolar endoprosthesis].

Between April 1985 and August 1986, 97 patients (101 hips) were treated with Bateman bipolar hemiarthroplasty after diagnosis of femoral neck fracture and ischemic necrosis of the femoral head at Veterans' General Hospital, Taichung. Seventy hips were followed up for an average of 44 months (range from 36 to 53 months). 58.6% of the patients had excellent or good results, 21.4% had fair results and 20% poor results. Twelve cases (17.1%) with thigh pain were diagnosed as have loosening of the stem and this was verified by X-ray and 99m Tc-MDP bone scan examination. 2 of these twelve cases received revisional total hip replacement. Wearing of the acetabulum was noted in only 2 patients (2.9%). From the short-term follow-up study, we would suggest that good results can be obtained with improved cementing technique or a special stem design to fit the different indications.

Adult↗
PubMed1988

Microskin grafting in the treatment of extensive burns: a preliminary report.

Microskin grafting has proved to be an effective new procedure for the treatment of extensive burns, in which only a minimum amount of autogenous skin is needed for coverage of a large full-thickness burn wound. The technique has been improved and applied in 17 major burn patients. All patients survived. The wound covered with microskin grafts ranged from 6% to 45% TBSA, with a mean area of 24.1% TBSA. The expansion ratio of micrografts in this series reached up to 1:18, and can be greater. The wound healing was accomplished in three ways. 1) Wounds were completely resurfaced by micrografts in 24 limbs (58.5%). 2) Wounds were not totally healed with micrografts by the time the homograft was rejected, leaving only small raw areas which needed re-grafting in 12 limbs (29.3%). 3) The micrografts did not take on four limbs and one chest wall (12.2%). The improved technique, which has become more simple and feasible, is discussed in detail.

Adolescent↗
PubMed1987

Treatment for severe burns of the chest wall with special reference to the involved ribs.

Deep burns of the chest wall may involve not only the skin but also the muscle and bone. If the ribs and sternum are severely damaged, it may not be easy to carry out adequate debridement of partially necrotic ribs and sternum. A procedure termed segmental chiselling debridement of bones is herein described. Four cases are presented in which patients with severely burned chests were successfully treated without complications by use of this procedure in this hospital.

Adult↗
PubMed1978

Malignant pituitary chromophobe adenoma in an infant accompanying diabetes insipidus.

This report deals with a 1.5-year-old male infant terminating in viral pneumonia and "diabetes insipidus". The autopsy revealed malignant pituitary chromophobe adenoma, invading the wall of the third ventricle, extending to the periventricular-, dorsomedial- and ventromedial area, skipping to the lateral area adjacent to the optic nerve, and permeating into the subarachnoid space of the cerebrum. At the onset of disease polydypsia and polyuria were marked followed by interstitial pneumonia with high fever, and later generalized tonic convulsion terminated in death. This case is peculiar in at least two respects. Firstly, this is the youngest reported case of malignant chromophobe adenoma. Secondly, the manifestation of diabetes insipidus is rare in chromophobe adenoma. The malignant adenoma probably occurred from the primitive gland rest of chromophobe cells in the posterior lobe becoming malignant during the course of growth development and destroyed the cells of the posterior lobe, resulting in diabetes insipidus.

Adenoma, Chromophobe↗
PubMed1976

Hemopoietic recovery in bone marrow of lethally irradiated rats following parabiosis. I. Granulopoiesis.

Aplasia was induced in rats by total body irradiation. Three days later, the animal was conjugated by aortic anastomoses with a healthy untreated litter-mate. 6 h after parabiosis, the bone marrow of irradiated animals contained some granulocytes showing RNA synthesis. At 18 h, many myelocytes and promyelocytes were present but no myeloblast was encountered. These myeloid precursor cells showed active DNA synthesis but no mitoses, and no erythroblasts were observed at this time period. At 24 h, mitoses of myeloblasts were found. At 42--60 h, erythropoiesis was evident. Chromosome analysis and investigations of cells of irradiated parabionts conjugated with partners having labeled cells, revealed that these newly formed myeloid and erythroid cells originated from the untreated parabiont. The mechanism of triggering myelopoiesis in the aplastic bone marrow by parabiosis is discussed.

Animals↗
PubMedDate not supplied

Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns.

This clinical trial prospectively evaluates the potential beneficial effects of antimicrobial drug delivery from a synthetic dressing (Hydron-AgSD) formed on second-degree burn wounds. A paste composed of polyethylene glycol-400, poly 2-OH ethylmethacrylate, and silver sulfadiazine (AgSD 1%-3%) matured within one hour to form a solid dressing. In 27 patients, comparable areas of second-degree wounds on the same patient were selected at random for test and control (silver sulfadiazine 1% only) sites. The mean total time of the synthetic dressing application per patient was about nine days, and each dressing remained in place for nearly four days. During this interval the control sites required four dressings changes. In 17 tests for infections, the control areas were contaminated but no bacteria were detected under the synthetic dressing; in three tests, the controls had no bacteria, whereas the synthetic dressing did. Healing of burns was similar under both types of dressing. Benefits of Hydron treatment included increased patient comfort because of the reduced number of dressing changes and, in some cases, greater freedom from contaminating bacteria.

Adolescent↗
PubMedDate not supplied

A preliminary report on transplantation of microskin autografts overlaid with sheet allograft in the treatment of large burns.

The technique of transplantation of autologous microskin grafts (MG) with overlays of split-thickness skin allografts was used in the treatment of nine extensively burned patients. Preparation of MG includes: 1) mincing small pieces of split-thickness skin autografts into skin particles (SPs); 2) dispersing the SPs evenly on a piece of silk cloth; 3) transferring SPs to the dermal surface of an allograft sheet (20/1000 in.); 4) transplanting the allograft with SPs to the excised wound. The mean burn area (total/3 degrees, mean +/- SEM) of this group was 74.9 +/- 16.6/62.1 +/- 18.1% TBSA (range 40 to 94/28 to 90%). The mean age was 27 years (range 19 to 38). Early staged excisions followed immediately by MG applications were performed on 35 large body sites, including extremities, chests plus abdomens and backs. The mean area excised and grafted with MG was 41.7 +/- 11.0% TBSA (range 26 to 62%). The average time for complete healing was about six to seven weeks postgrafting. Eight patients survived; one died of overwhelming pulmonary infection 22 days postburn. Advantages of this technique are: 1) the great potential of MG to provide a large expansion ratio of 8:1 to 15:1, average greater than 10:1 in this series; 2) good maintenance of the healed graft to withstand trauma except in areas of repeated flexion; 3) ease of preparation and application with less cost compared to cultured epidermal sheet grafts; 4) prevention of infection in extremely large burns by providing continuous epidermal coverage following sheet allograft application.

Adult↗
PubMedDate not supplied

Comparison of scar contracture with the use of microskin and Chinese-type intermingled skin grafts on rats.

Wounds that were measured precisely 4 x 5 cm in size were created over the dorsal surfaces of rats. The defects were grafted with the use of either the microskin or Chinese technique of intermingled auto/allograft with an expansion ratio of 10:1. The size of the grafted wound of each rat was recorded on the fifth graft day after grafting and then weekly for 11 weeks. The extent of scar contracture on each rat was calculated weekly as a percentage of the original size. The results showed that the scar contracture associated with the Chinese type of intermingled auto/allograft transplantation was less than that associated with the microskin technique. The healing process in both forms of grafting was uneventful.

Animals↗
PubMedDate not supplied

Observations on stability and contraction of composite skin grafts: xenodermis or allodermis with an isograft overlay.

Composite skin grafts of xenodermis or allodermis with a thin split-thickness isograft overlay were evaluated for stability and contraction. Male inbred Lewis rats were used as recipients, with Buffalo rats serving as allogeneic dermis donors. Cryopreserved human skin was used for xenodermis grafts. The two components of the composite graft, the xenodermis or allodermis and the isograft overlay, were grafted in one operation to a surgically created wound. Wounds were observed for 1 year. The composite skin grafts took fairly well, although spotty loss of the overlaid isograft was noted. The xenodermis and allodermis remained grossly intact even at 1 year after grafting. However, composite skin grafts in this animal model contracted more than did sheet isografts alone.

Animals↗