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C H Gips

Publications and source records attributed to C H Gips.

At least 73 records · Page 4Linked to original sources
PubMed1980

Anti-HBc titers and anti-HBc immunoglobulin (M/G) classes in acute, chronic and resolved hepatitis B.

IgM-anti-HBc and IgG-anti-HBc serum titers were determined by indirect immunofluorescence in a prospective longitudinal study of 50 patients with hepatitis B, 43 of whom recovered completely. 37 of the recovered patients and all 7 non-recovering patients were followed up for a median of 5 years. Five of the non-recovering patients were followed up from the initial acute stage of the disease. IgM-anti-HBc was present in the acute stage in 39/43 of the recovery patients. The median maximal titer, 1:1000, was reached during the week before peak SGPT. It always disappeared in recovering patients within a median period of 5 weeks after peak SGPT. IgG-anti-HBc was present in all 43 recovering patients in the acute stage of disease with a median maximal titer of 1:1000, maintained for at least 10 weeks. After 5 years, 28 of 37 recovered patients were still IgG-anti-HBc positive with a median titer of 1:200. All non-recovering patients showed persistent IgM as well as IgG-anti-HBc positivity. In the acute stage the medians of the maximal titers were 1:100 for IgM-anti-HBc and 1:1000 for Igg-anti-HBc. After 5 years they were 1:100 for IgM and 1:10000 for IgG-anti-HBc. The presence of IgM-anti-HBc in a preceding study was considered to be a marker of hepatitis B virus replication. From this study no evidence can be obtained to support the view that the titer level of anti-HBc is reliable in the differentiation between infectious anti-HBc positive blood, as there was no difference (p = 0.4) between the number of patients with an anti-HBc level of 1:1000 after at least five years, who had recovered (9/28) and who had not recovered (3/7).

Acute Disease↗
PubMed1980

Preference and significance of HBeAg and anti-HBe, determined by enzyme immunoassay, in patients with acute, chronic and resolved hepatitis B.

HBeAg and anti-HBe were determined by enzyme immunoassay in a prospective longitudinal study of 50 patients with hepatitis B, 43 of whom recovered completely. Followup studies were possible in 37 of the recovered patients and in all 7 non-recovering patients for a median of 5 years. Five of the non-recovering patients could be followed up from the initial acute stage of the disease. HBeAg was present in 17 of 18 recovering patients from whom serum was still available from the early stage of disease (i.e. before peak SGPT levels were reached). The presence of HBeAg was transitory for a median period of one week before the peak SGPT level until it was actually attained. All HBeAg-positive serums contained HBsAg and IgM-anti-HB core as well. 39 of the 43 recovering patients developed anti-HBe, first present after a median period of 2 weeks after peak SGPT. After 5 years 25 of 30 tested patients were still anti-HBe positive, all were HBeAg (and HBsAg) negative. Of the non-recovering patients 2 remained HBeAg-positive for at least 4 years, 4 seroconverted to anti-HBe between 0.5 and 2.5 years after the acute stage of the disease, without apparent correlation with the biochemical activity or the histological diagnosis, and 1 patient already had anti-HBe in the acute stage of the disease. Thus HBeAg is as a rule transiently present in acute hepatitis B, during early stages of the disease. HBeAg has been regarded commonly as a viral constituent. The conversion from HBeAg to anti-HBe in the patients with chronic hepatitis B, however, may cast doubt on this assumption in favour of the hypothesis that the HBe/anti-HBe system is of host origin. Anti-HBe, when present without markers of virus replication, may serve as a sign of previous, completely resolved hepatitis B.

Acute Disease↗
PubMed1980

[Prognosticated longevity quotient (PLQ) and the assessment scale for older patients].

In a previous article was demonstrated that the physician is over-optimistic while making an individual prognosis as to survival in patients of a psychogeriatric nursing home. In this investigation we have tried to relate the individual prognosis to the BOP (a Dutch derivative of the Stockton Geriatric Rating Scale). We introduced the term Prognosticated Longevity Quotient: the prognosticated survival in years divided by the expectation of life in Netherlanders of the same age and sex. In the 217 patients, prospectively studied, an inverse relation was found between PLQ- and BOP-values. At the end of the 45-months lasting investigation period, the initial PLQ turned out to have been lower and the BOP higher in those who had died compared to those who survived. Chances of being alive were greater in those with an initial PLQ > 0,5 while initial placement in an increasingly higher BOP-class indicated a decreasingly smaller chance of survival.

Age Factors↗
PubMed1980

[Developmental reflexes and parkinsonism in mentally disturbed aged: a 1-year follow-up study].

In an earlier publication we reported on the incidence of developmental reflexes and symptoms of parkinsonism in 100 psychogeriatric patients with a mean age of 81 years. This article deals with the follow-up, one year later. The 24 patients who had deceased between the two investigatins appeared to have had a higher incidence of the palmomental reflex than those surviving. In the 75 patients who could be reinvestigated, the following findings were made. No developmental reflexes or symptoms of parkinsonism were found in 11 patients during the first and in 15 during the second investigation, 5 of these had the same results in both. The number of developmental reflexes had increased 34% and the number of symptoms of parkinsonism 29% from the first to the second investigation. The BOP (a Dutch derivative of the Stockton Geriatric Rating Scale, in which the higher score indicates the higher need of care) in those having two examinations was lower in the first. There were considerable changes in the number and the kind of reflexes and symptoms of parkinsonism from the first investigation to the second.

Aged↗
PubMed1979

[Survival of patients admitted to a psychogeriatric nursing home].

The survival of 522 patients, admitted to a psychogeriatric nursing home between 1966 and 1976, was compared with that of the Dutch population, after matching for age and sex. Survival rates were lower in the investigated population; this was particularly influenced by the relatively high mortality of the psychogeriatric patients, who comprised 74% of the investigated population. In women survival rates were better than in men. The survival of married patients was shorter than the same in single patients, while it in the very old was relatively shorter than in the younger group of aged persons.

Age Factors↗
PubMed1978

Immunoglobulin classes of smooth muscle antibody in the course of acute hepatitis B: prognostic significance.

A prospective longitudinal study was performed in 48 patients with acute hepatitis B (AHB) of whom 38 were previously healthy (PH) and 10 drug addicted (DA). Smooth muscle antibody was present in 23/38 PH and in 8/10 DA patients for a median of 4 weeks; other autoantibodies were not found. In the PH patients SMA was of IgM class in 23/23 and 8/23 of the IgG class as well. In the 8 DA patients 2 had IgM-SMA only, 3 (IgM+IgG)-SMA and 3IgG-SMA only. IgG-SMA presence could not be related to the duration or titer height of SMA nor to the type of fluorescence patterns. In SMA-negative patients IgM-anti-HBc was cleared within 6 weeks and in IgM-SMA positive patients within 32 weeks (medians 4 and 5 weeks) after maximal S-GPT. IgM-anti-HBc persisted for years in 3/3 IgG-SMA positive and in 2/11 IgG-IgM positive patients. In the remaining 9 IgG-IgM SMA positive patients it disappeared within 15 (median 9) weeks after maximal S-GPT. All 34 patients without SMA or with IgM-SMA only recovered completely. The 3 patients with IgG-SMA and 2 of the 11 patients with IgG+IgM SMA developed chronicity. Determination of SMA and of its immunoglobulin classes, at maximal SGPT may in acute hepatitis B be of help in predicting the outcome of disease.

Adolescent↗