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Biomedical subjects

C H Hill

Publications and source records attributed to C H Hill.

7 recordsLinked to original sources
PubMed1979

Tongue lesions in children.

A review of tongue lesions in children showed that there is a great variety requiring operative intervention, often in infancy. While the presenting symptoms may be related to dysphagia and dyspnea, the aim of operative intervention should not only be to salvage life by restoration of breathing and swallowing, but also to leave a tongue capable of adequate speech, taste, sensation, and normal orofacial development. Intimate knowledge of lingual anatomy and function is necessary to allow selection of the ideal procedure and appropriate timing of the therapy. While careful observation and nonoperative approach may be indicated in non-neoplastic macroglossia, early intervention is often necessary in diffuse neoplastic lesions such as lymphangioma, fibromatosis, or fibrolipomatous dysplasia. While malignant tumors are rare in childhood, they do occur and have to ruled out.

Adolescent↗
PubMed1979

Studies on the ameliorating effect of ascorbic acid on mineral toxicities in the chick.

The effect of dietary ascorbic acid on the toxicity of high levels of cobalt, selenium, vanadium, cadmium, copper, and mercury was determined in chicks. The vitamin reduced the growth retardation caused by cobalt, selenium, vanadium, and cadmium administration but had no such effect on copper and mercury toxicity at the levels used. The effect of ascorbic acid on growth could not be mimicked by ferrous iron administration. Ascorbic acid did not alleviate the increased susceptibility of chicks to Salmonella gallinarum caused by feeding high levels of these elements.

Animals↗
PubMed1979

The effect of dietary protein levels on mineral toxicity in chicks.

Studies have been conducted to determine the influence of dietary protein levels of 10, 20, and 30% fed as soybean meal on the toxicity of selenium, cadmium, vanadium, cobalt, and nickel to chicks. The toxicity was evaluated in terms of growth retardation and a decrease in resistance to S. gallinarum infection as measured by mortality. The toxicity of selenium or cadmium was unaffected by the protein level of the diet while the toxicity of vanadium, cobalt and nickel was decreased by increased dietary protein as measured by the interactions on growth. The interactions apparent on growth were not as apparent on resistance to infection indicating that the latter parameter is much less sensitive to these dietary manipulations than is growth.

Animals↗
PubMed1979

Dietary influences on resistance to Salmonella infection in chicks.

Studies on the influence of nutritional factors on the resistance of chicks to Salmonella gallinarum have been reviewed. Increased dietary protein decreased the resistance of chicks to this infection although resistance to Escherichia coli infections was not appreciably affected. The administration of high levels of iron, particularly when accompanied by a chelating agent such as EDTA, resulted in increased resistance to this infection. The additional iron resulted in the prevention of the transient hypoferremia and anemia during the course of the disease. Fewer viable S. gallinarum were present in the blood, liver, and spleen in the presence of increased dietary or injected iron. Cadmium added to the diet at a nontoxic level also enhanced resistance to this infection.

Amino Acids↗
PubMed1978

Abnormal cellular copper metabolism in the blotchy mouse.

Defective copper metabolism was demonstrated in male mice bearing the blotchy (Moblo/y) allele at the mottled locus on the X-chromosome. Copper absorption from the gut was only 64% of that found in normal mice and hepatic copper levels were only 56% of the controls. Ceruloplasmin and heart cytochrome c oxidase activities were normal, yet lysyl oxidase activity from cultured fibroblasts was only 45% of control levels. Copper accumulated in fibroblasts cultured from these mutants to values that were five times normal. The accumulation of copper in the fibroblasts was associated with a protein of approximately 12,000 molecular weight.

Alleles↗
PubMed1978

Biological interaction of selenium with other trace elements in chicks.

Studies were conducted to determine whether or not elements whose valence shell of electrons was similar to that of selenium would reverse the toxicity of selenium to chicks. The elements studied were arsenic, tellurium, tin, and lead. Each of these elements, when added to the diet of chicks, reversed the toxicity of 25 ppm selenium as measured by weight gain. In spite of the protection afforded by these elements, there was no decrease in liver concentration of selenium except with levels of arsenic higher than that needed for reversal of toxicity.

Animals↗