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Biomedical subjects

C H Jacobsen

Publications and source records attributed to C H Jacobsen.

2 recordsLinked to original sources

Epiretinal membranes.

Epiretinal membranes are a common finding in older patients but are rare in young patients. Although they may be associated with other ocular conditions, most epiretinal membranes occur in the absence of ocular pathology. Patient symptoms range from asymptomatic to complaints of severe vision loss and metamorphopsia. Epiretinal membranes are commonly classified according to their density and contractile characteristics. In this review, cellophane maculopathy refers to thin, glistening membrane, surface wrinkling maculopathy is characterized by fine, superficial retinal folds and macular pucker is associated with a dense, grayish-white membrane causing a characteristic pattern of severe retinal distortion. With sufficient visual disturbance, epiretinal membranes may be treated by pars plana posterior vitrectomy and epiretinal membrane peeling.

Diagnosis, Differential↗

Hypothalamic knife cuts that disrupt mating in male gerbils sever efferents and forebrain afferents of the sexually dimorphic area.

The sexually dimorphic area (SDA) of the gerbil hypothalamus is essential for male sexual behavior. To determine (a) if the SDA can affect mating via laterally projecting axons and (b) which SDA afferents might affect mating, male gerbils were given bilateral, parasagittal knife cuts lateral to the medial or lateral SDA. Others were given cuts with a knife coated with horseradish peroxidase to label cells of which axons were cut. Medial cuts eliminated mating and consistently labeled cells in the medial SDA. Lateral cuts did neither. Medial cuts also labeled more cells in the ventral part of the lateral septal nucleus, the encapsulated part of the bed nucleus of the stria terminalis, the medial nucleus of the amygdala, the amygdalohippocampal area, and the ventral premammillary nucleus than lateral cuts did. Thus, medial cuts may disrupt mating by severing SDA efferents or by severing SDA afferents from 1 or more of these 5 sites.

Afferent Pathways↗