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Biomedical subjects

C H Kellner

Publications and source records attributed to C H Kellner.

85 records · Page 5Linked to original sources
PubMed1985

Self-destructive behavior in hospitalized medical and surgical patients.

This article reviews the literature and presents data from the Psychiatric Consultation Service of the Medical University of South Carolina on self-destructive behavior in hospitalized medical and surgical patients. Fatal suicide attempts are rare and usually occur in patients with severe, painful chronic illnesses, psychosis, or dementia. Less overt forms of self-destructive behavior include refusal of medical treatment and uncooperative behavior.

Adult↗
PubMed1985

Lithium intolerance disproved by blind clinical trial.

Two patients, previously labeled lithium "intolerant," tolerated lithium without side effects when it was given on a double-blind basis. Blind medication trials may be clinically useful in some cases for determining the true nature of drug side effects.

Adult↗
PubMed1984

Rapidly cycling bipolar disorder and multiple sclerosis.

The authors describe two patients with rapidly cycling bipolar disorder who were found to have multiple sclerosis. They suggest that multiple sclerosis be considered in the differential diagnosis of patients who have affective disorders and minor neurological complaints.

Adult↗
PubMed1983

Relationship of cortisol hypersecretion to brain CT scan alterations in depressed patients.

Preliminary data showing a correlation between urinary free cortisol levels and ventricular-brain ratio in 10 affectively ill patients are presented. The literature on hypercortisolism and computed tomography (CT scan) abnormalities is reviewed. The authors suggest that the increased cortisol production in some psychiatric patients might be capable of altering the gross structure of the brain and that such alterations might be reversible.

Adult↗
PubMed1982

Code blue--factitious cyanosis.

The authors report a case of factitious cyanosis in a psychiatric inpatient. To their knowledge, this is the first report of factitious cyanosis in the medical literature. They discuss the relationship of isolated factitious signs and symptoms to Munchausen syndrome and other psychiatric diagnoses. They explore the underlying dynamic of displaced anger in this patient. They suggest that avoiding confrontation with these patients may lead to a better therapeutic outcome and caution physicians to be alert to the possibility of factitious etiology when presented with confusing symptom clusters.

Cyanosis↗
PubMedDate not supplied

Effect of fluvoxamine, imipramine and placebo on catecholamine function in depressed outpatients.

Many of the specific serotonin reuptake inhibitors appear to have some effect on noradrenergic function. Fluvoxamine is one of the newer agents and its specificity has not been fully assessed. Depressed patients participating in a study comparing the efficacy of fluvoxamine with imipramine and placebo collected 24 hour urine samples (N = 38) and had plasma samples drawn (N = 38) prior to and after 6 weeks of double blind treatment. Urine samples were analyzed for 24 hour output of MHPG, VMA, NMN, MN and HVA. Plasma samples were analyzed for NE levels. Imipramine treatment produced a reduction in urinary MHPG, an increase in the ratio of NMN to MHPG plus VMA, and a trend towards an increase in plasma NE which was significantly different than the effects seen in the fluvoxamine and placebo groups. There was an additional finding in the imipramine group of a significant correlation between percentage change in plasma NE and clinical improvement. Fluvoxamine treatment, on the other hand, produced no clear effect on any measure of noradrenergic function and the antidepressant efficacy of fluvoxamine was unrelated to any noradrenergic variable. These findings lend support to the hypothesis that fluvoxamine does not have significant effects on noradrenergic function.

Adolescent↗
PubMedDate not supplied

Cerebral ventricular size and cognitive impairment in depression.

Twenty-one patients with major affective disorder were given the Halstead-Reitan Category Test and had CT brain scans performed in order to measure ventricular-brain ratio (VBR). A significant correlation between ventricular size and cognitive impairment was found. Possible pathophysiological mechanisms that might explain this relationship are discussed.

Adult↗
PubMedDate not supplied

Cerebral ventricular size in panic disorder.

Computed axial brain tomography was studied in 25 patients with panic disorder. Patients had normal ventricular-brain ratio (VBR) compared to published norms. There was a significant association between VBR and duration of benzodiazepine use.

Adult↗