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Biomedical subjects

C H Kinder

Publications and source records attributed to C H Kinder.

12 recordsLinked to original sources

Renal function following surgical correction of vesico-ureteric reflux in childhood.

To assess the effectiveness of the surgical correction of vesico-ureteric reflux, current renal function was determined in 56 children with scarred kidneys who had undergone ureteric reimplantation between 1978 and 1983. The children were aged between 2 and 15 years, had no coexisting urological disease and a glomerular filtration rate (GFR) of less than 90 ml/min/1.73 m2. In the 32 patients who had bilateral reimplantation of ureters draining bilaterally scarred kidneys the improvement in GFR following surgery was highly significant (P less than 0.001), with improvement occurring in 75%. The greatest improvement was in patients where the GFR was less than 50 ml/min/1.73 m2 (29%). Individual kidney GFR was estimated in 42 kidneys and 81% improved after surgery. This improvement was highly significant (P less than 0.001).

Adolescent↗

Hypertension and thromboembolism in idiopathic retroperitoneal fibrosis.

Of 36 patients with idiopathic retroperitoneal fibrosis treated surgically, 8 have died and 26 have suffered 67 post-operative complications during 1 to 24 years of follow-up. Four patients died as a consequence of hypertension. Hypertension and thromboembolism accounted for 49% of the post-operative complications in 69% of the patients who developed complications. Attention to these 2 factors is at least as important as prevention of recurrent obstructive uropathy.

Adult↗

Neuropathic vesicourethral dysfunction in children. A trial comparing clean intermittent catheterisation with manual expression combined with drug treatment.

Forty-three children with overt neurological disease and neuropathic vesicourethral dysfunction were entered into a trial comparing clean intermittent catheterisation (CIC) with manual expression combined with drug treatment (non-CIC). The 22 children in the CIC group showed a significantly greater improvement in continence than the 21 children in the non-CIC group (P less than 0.001) without a significant increase in the incidence of urinary tract infections. Neither form of treatment is effective in reducing the risk of deterioration of renal function due to the combination of detrusor-sphincter dyssynergia and vesicoureteric reflux. Neither form of treatment improves continence in the presence of gross sphincter weakness or gross impairment of bladder compliance.

Bethanechol Compounds↗