PubMed Health⌕ Search

Biomedical subjects

C H Pan

Publications and source records attributed to C H Pan.

33 records · Page 2Linked to original sources
PubMed1990

[Plasma levels of atrial natriuretic factor (ANF) in the stroke patients after glycerol and mannitol infusion].

This study included 43 patients with stroke in a range of 48 to 85 years of age. Among them, 24 were male and 19 were female. Changes in blood pressure, plasma ANF (by radioimmunoassay), serum sodium, and serum osmolarity before and 40 minutes after hyperosmotic agents infusion were studied. The stroke was classified to be putaminal hemorrhage in 12 cases, thalamic hemorrhage in 5 cases, putaminothalamic hemorrhage in 2 cases, lobar hematoma in 2 cases, cerebral infarction in 20 cases and brainstem ischemic stroke in 2 cases. Twenty-nine patients received glycerol and the other fourteen received mannitol. After glycerol or mannitol infusion, the plasma ANF raised significantly (P less than 0.05, paired Student's test), also the serum osmolarity (P less than 0.05, paired Student's t test), but the blood pressure and serum sodium kept unchanged. Either before or after the hyperosmotic agents, no significant difference in plasma ANF was noted between the hemorrhagic and infarction patients, between the right and the left hemispheric stroke, or between male and female patients. We did not observe age-related (less than 65 or greater than 65 years) difference in plasma ANF concentration in this study, either.

Aged↗
PubMed1989

[Brainstem auditory evoked potentials in head injury patients].

This study was designed to evaluate the alterations in brainstem auditory evoked potentials (BAEPs) in patients with head injuries. BAEPs were recorded of twenty-five normal subjects to serve as control group. Fifty-four patients with head injuries were evaluate prospectively by neurological check-ups, the Glasgow coma rating scale, brain CT scans, as well as BAEPs. Among them, twenty-two patients accepted a follow-up evaluation one month after the first study. In the acute stage, though the significant prolongation of peak latency occurred only in the right peak III as compared with the control group, the rate of presence decreased significantly in most of the peak waves. There were three main types of abnormality: isoelectric BAEP (13.0%), alterations in peak I (29.6%) and in interpeak latencies (13.0%). The incidence of abnormal BAEPs was 48.2% of 54 patients. Patients were divided into two groups according to whether their coma scale was above/equal to or below 9. No significant difference was shown in the rate of appearance of wave peaks and the average latency of each peak wave. This suggests BAEPs displayed a function of the auditory pathway only rather than a reticular formation in the brainstem. Concerning the group with brain stem abnormality as shown in CT scan, there was significant prolongation in most peak and interpeak latencies, and the rate of presence of each peak was significantly lower compared with the non-brainstem-abnormality group. Therefore, the alteration in BAEPs in head injuries coincide with the presence of abnormal brainstem signs in the CT.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

Thymolipoma in patients with myasthenia gravis: report of two cases and review.

Two cases of simultaneous occurrence of myasthenia gravis (MG) and thymolipoma are described and 4 previously reported cases are reviewed. In all 6 cases, thymectomy was performed. Pre- and postoperatively, the clinical status of the patients was similar to that of late-onset MG without thymolipoma. It is possible that simultaneous occurrence of MG and thymolipoma may be coincidental.

Azathioprine↗
PubMed1987

Actinoidin A2, a novel glycopeptide: production, preparative HPLC separation and characterization.

An unidentified Nocardia sp. (SK&F-AAJ-193) was isolated and found to produce actinoidin A and a novel analog which we have named actinoidin A2. This new glycopeptide antibiotic differs from actinoidin A by the presence of rhamnose instead of acosamine. This analog was isolated using Dianion HP-20 resin followed by a specific glycopeptide affinity column (Affigel-10-D-Ala-D-Ala). The purification was accomplished using preparative ion-pairing chromatography. Actinoidin A2 is active against Staphylococcus aureus and coagulase-negative Staphylococci although it is less potent than actinoidin A.

Animals↗
PubMed1986

Kibdelins, novel glycopeptide antibiotics. I. Discovery, production, and biological evaluation.

A new subspecies of Kibdelosporangium aridum subsp. largum (SK&F AAD-609), was isolated and shown to produce novel glycopeptides related to aridicins, but containing a homologous series of glycolipids based on N-acylglucosamine. These compounds showed improvements over the aridicins in in vitro activity and were effective in mouse protection studies against a range of Gram-positive bacteria, including methicillin resistant staphylococci. Pharmacokinetic studies indicated that they have high serum concentrations and long-acting potential. The kibdelin complex modified rumen metabolism in a manner favorable for growth promotion.

Actinomycetales↗
PubMed1985

Chlorocardicin, a monocyclic beta-lactam from a Streptomyces sp. I. Discovery, production and biological activities.

Chlorocardicin is a new monocyclic beta-lactam produced by a Streptomyces sp. It is structurally related to nocardicin A but differs in having a m-chloro substituent on the p-hydroxyphenylglycine unit. The biological activity of chlorocardicin was similar to nocardicin A but the former showed less antagonism in complex media. Moderate in vitro activity was observed against Enterobacteriaceae and Pseudomonas aeruginosa. Chlorocardicin showed low activity against Staphylococcus aureus whereas nocardicin A was inactive. Both compounds were shown to be strongly potentiated by antibiotics that inhibit peptidoglycan biosynthesis and were antagonized by selected L- and D-amino acids.

Anti-Bacterial Agents↗
PubMedDate not supplied

Establishment and characterization of NS3 protein-specific T-cell clones from a patient with chronic hepatitis C.

Our previous study showed dominant proliferative response of peripheral mononuclear cells to hepatitis C virus (HCV) nonstructural (NS-3) (T9, from aa 1188 to 1493) in chronically infected patients. Six T9-specific T-cell clones derived in an HCV patient were established and studied for the antigen specificity and the ability of augmentation of in vitro antibody production. All these cloned T-cell lines responded exclusively to T9 antigen and could help autologous B cells in producing anti-T9 antibody in vitro. Cytokine mRNAs of these T cells was detected by polymerase chain reaction and predominant IL-2 and IFN-gamma production was noted. In addition, further elucidation of T-cell antigenic determinant and MHC restriction suggested that these T-cell clones recognized at least two different T-cell antigenic determinants within the NS-3 region in an HLA DQ2-restricted manner. We believe characterization of HCV-specific T-cell responses, especially T-cell epitope mapping and cytokine production pattern, may shed light on further understanding the pathogenic mechanism and designing therapy for HCV infection.

Antibody Formation↗