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Biomedical subjects

C H Pires

Publications and source records attributed to C H Pires.

2 recordsLinked to original sources
PubMed1992

Capsular contracture and silicone gel: experimental study.

Wistar rats were used to study the effects, if any, of membrane thickness and implant volume of a silicone gel prosthesis on the development of fibrous capsule contraction. A total of 30 miniprosthesis with three different membrane thicknesses and two different volumes were implanted in the subcutaneous space of five animals. One hundred eighty days later the fibrous capsule was resected and histologically analyzed. Different grades of thickness were observed. The statistical analysis of the data indicates that the thickness of the prosthesis' membrane and the implant's volume did not impact significantly on the grade of fibrosis.

Animals↗
PubMed1989

[The heart and diabetes. An anatomo-clinical study].

We performed a retrospective study in 72 autopsies of diabetic patients (DMP) selected out of 2,239 adult autopsies, comprehending the period between 1966 to 1982. In order to analyse the possible Diabetic Cardiomyopathy, the DMP were divided into 8 groups according to the presence or the absence of Myocardial Fibrosis (MF) and Congestive Heart Failure (CHF). The Diabetes Mellitus (DM) incidence according to the race, sex, age and the presence of Kimmestiel-Wilson (KW) were in agreement with the literature data. The majority of the deaths occurred after the sixth-decade and we did not find any DMP with Malignant Hypertension. Hypertension and Coronary Artery Disease (CAD) increased the frequency of anatomical cardiac alterations, as follows: 1. MF was more associated with CAD, 2. Hypertension was more frequent in DMP with KW in the nodular form; 3. Hypertension increased the frequency of left ventricular hypertrophy; 4. Myocardial Infarction occurred in the absence of occlusive vascular phenomena. The Myocardial Fibrosis (MF) observed in DMP without ACD and without hypertension may be final anatomic demonstration of a gradual metabolic-functional process, and not the basic mechanism of the CHF in the possible Diabetic Cardiomyopathy.

Adolescent↗