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Biomedical subjects

C H Raine

Publications and source records attributed to C H Raine.

At least 19 recordsLinked to original sources
PubMed2006

The Bradford bone-anchored hearing aid programme: impact of the multidisciplinary team.

OBJECTIVES: The aim of this study was to assess the impact on implant survival, abutment skin reaction and patient satisfaction in patients implanted with a bone-anchored hearing aid (BAHA), following the introduction of a multidisciplinary team (MDT) in 1997. DESIGN AND METHODS: Part prospective and retrospective analysis. Implant survival and cause of failures were recorded along with abutment skin reaction (graded as none, mild, moderate and severe, according to the amount of wound care required). Patient satisfaction and quality of life were assessed using a questionnaire enquiring about several aspects of the use and benefits of their BAHA. SETTING AND PARTICIPANTS: Eighty patients treated at the Bradford Royal Infirmary between 1991 and 2005. The unit is a recognized tertiary referral centre. RESULTS AND CONCLUSIONS: Twelve out of 80 implants failed, giving an overall failure rate of 15 per cent. Kaplan-Meier survival curves show a steady decrease in implant survival. The MDT had a positive effect on implant survival and adverse skin reactions, with a higher proportion of patients experiencing no reaction after its introduction. There was a 92.5 per cent response rate to the questionnaire. Overall patient satisfaction was high, both before and after the introduction of the MDT.

Adolescent↗
PubMed2002

Cochlear implantation in Jervell and Lange-Nielsen syndrome.

A case of familial prolonged QT interval and congenital sensorineural hearing loss is described emphasising the diagnostic and management implications. Jervell and Lange-Nielsen syndrome is important because of its potential association with sudden death in children with congenital sensorineural deafness. It is known to be associated with mutations of the genes KCNQ1 (KVQTI) and KCNE1 (Isk). The underlying molecular abnormality leads to cardiac and cochlear dysfunction through a potassium channel defect. All children with congenital sensorineural hearing loss who have suffered unexplained syncopal attacks or convulsions should be screened for this syndrome. There is also a strong case for including a 12 lead ECG as part of the investigative work up of all children with congenital sensorineural deafness in whom a firm aetiology has not been established.

Adolescent↗
PubMed2001

Cochlear and middle ear implants: advances for the hearing impaired.

We have entered into an era of surgical audiology with cochlear and middle ear implants. With both devices there are distinct phases of patient management--patient selection, surgery, programming and rehabilitation. These phases and issues relating to the implants themselves are considered in this article.

Adult↗
PubMed1999

Improvement in severe insulin resistance with frequent injections of lispro insulin.

Extreme insulin resistance is common in obese African Americans with type 2 diabetes. This case report describes an obese African-American woman who was treated with subcutaneous injections of lispro insulin every 2 hours with resultant decrease of mean daily blood glucose from 264.7 mg/dL to 111 mg/dL and in insulin requirement from 479 U/24 hours to 60 U/24 hours. This case demonstrates that extreme insulin resistance is reversible in the short term.

Diabetes Mellitus↗
PubMed1998

An endoscopic photographic comparison of nasal drug delivery by aqueous spray.

There is general agreement that the delivery of topical nasal medication by sprays is suboptimal. This study examines the distribution of spray to the anterior end of the middle turbinate as a guide to the distribution to the middle meatus by means of an endoscopic photographic comparison using dyed aqueous nasal spray. The technique was found to be reproducible. The effect of vigorously inhaling whilst spraying was studied by means of a randomized crossover trial and was found to have no significant effect. This technique could be used in conjunction with other means of assessing intranasal distribution when assessing improved topical nasal drug delivery systems.

Administration, Intranasal↗
PubMed1998

Intracochlear factors contributing to psychophysical percepts following cochlear implantation.

The performance of cochlear implant patients may be related to intracochlear, histopathological factors. We have performed detailed post-mortem examinations of five human, implanted cochleas and for each electrode correlated the psychophysical threshold, comfortable level and dynamic range with spiral ganglion cell survival, presence of fibrous tissue and/or new bone, and distance between the centers of the electrode bands and Rosenthal's canal. The psychophysical parameters were strongly interrelated. Threshold and comfort levels correlated with the distance between the electrodes and Rosenthal's canal. Threshold levels also correlated with the presence of intracochlear fibrous tissue and new bone, especially with the former. The dynamic range showed a negative correlation with intracochlear pathology, especially with new bone. Comfort levels and dynamic range were related to spiral ganglion cell survival. The distance between the electrodes and the modiolus increased with increasing levels of fibrous tissue and new bone. Spiral ganglion cell survival was decreased with increasing levels of fibrous tissue and new bone.

Adult↗
PubMed1995

Anomaly of the facial nerve and cochlear implantation.

The incidence of preoperative damage to the facial nerve in cochlear implantation is very low. The course of the facial nerve is not routinely evaluated preoperatively, but variations in its course can restrict access to the round window and impede implantation. In 5 of 42 operations, direct visualization of the round window was not possible. In 1 patient there was an obvious congenital bifurcation. Successful implantation was made possible by mobilizing the nerve.

Adult↗
PubMed1994

An open safety pin in the larynx: a case report.

Inhalation of a foreign body is a serious event. The number of foreign bodies that become impacted in the larynx is small and requires urgent recognition. We describe the case of a six-month-old baby with an impacted open safety pin in the larynx. The sharp end of the safety pin was upwards and had penetrated the anterior end of the left vocal fold. We discuss the management and describe our method of removal of the foreign body. Tracheostomy was not required in this case and the child had an uneventful recovery. A brief review of the literature is included.

Foreign Bodies↗
PubMed1992

A prospective study of factors which may predispose to post-operative tonsillar fossa haemorrhage.

Adeno-tonsillectomy and tonsillectomy are frequently performed and haemorrhage remains an important post-operative complication. A prospective study of 1090 patients undergoing surgery over a 12-month period was undertaken investigating whether the following factors influenced post-operative haemorrhage: age and sex of patients, method of tonsillectomy, haemostasis and premedication, month of operation and experience of surgeon. A significantly higher incidence of post-operative haemorrhage occurred in the group aged 16-25 years and significantly more males suffered post-operative haemorrhage. This haemorrhage more frequently occurred in the warmer months of May to July. Guillotine tonsillectomy was found to be as effective as dissection and no higher incidence of post-operative haemorrhage was recorded. Method of haemostasis, surgical experience and premedication did not influence the outcome. We conclude that the guillotine used in controlled circumstances is as safe as dissection.

Adenoidectomy↗
PubMed1987

The presentation of laryngeal tuberculosis.

Laryngeal tuberculosis is now a rare disease. We report 6 patients presenting within a 10-year period (1976-1986). Symptoms and signs often mimic carcinoma or chronic non-specific laryngitis. Greater clinical awareness and a chest radiograph prior to direct laryngoscopy may alert the clinician to the possibility of tuberculosis. The diagnosis is established by laryngeal biopsy.

Adolescent↗
PubMed1984

Bacteriological assessment of patients undergoing major head and neck surgery.

The use of chemoprophylaxis in major Head and Neck surgery is controversial. Prior to conducting a prospective trial a controlled microbiological monitoring of 32 patients was performed to determine a suitable antibiotic for prophylaxis. Wound infection occurred in 22 (68%) patients with fistulae occurring in 10 of these patients (45.5%). Pre-operative cultures were of limited value in predicting subsequent sepsis. Gram-negative aerobic bacilli were the commonest group of pathogens (34.4%) isolated post-operatively. From projected resistance profiles of pathogenic and opportunistic bacteria amoxycillin and clavulanic acid (Augmentin, Beecham Pharmaceuticals) was chosen as a suitable antibiotic.

Anti-Bacterial Agents↗
PubMed1984

Chemoprophylaxis in major head and neck surgery.

Wound infections are a significant complication following major oncological head and neck surgery. In view of the controversy surrounding the use of chemoprophylaxis a controlled trial was designed. Intravenous Augmentin (amoxycillin and clavulanic acid) was shown to reduce significantly (P less than 0.025) the incidence of postoperative sepsis.

Adult↗
PubMed1983

A comparison of the effects of intermittent and continuous nasogastric feeding on the oxygen consumption and nitrogen balance of patients after major head and neck surgery.

Ten patients were fed by nasogastric tube for 5 days after major surgery of the head and neck. Five were fed by continuous infusion 24 h/day using an enteral nutrition pump and five were fed comparable quantities by 2-h bolus administration between 0600 and 2200 h. Those fed by bolus had lower resting oxygen consumption on the 4th and 5th postoperative days and better cumulative nitrogen balance over the 5 days than the continuously fed group. It appears that metabolically it may be better to use an intermittent feeding regimen than a continuous one when feeding patients postoperatively via a nasogastric tube.

Enteral Nutrition↗