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Biomedical subjects

C H Ramírez-Ronda

Publications and source records attributed to C H Ramírez-Ronda.

At least 55 records · Page 3Linked to original sources

Cefamandole in the treatment of soft tissue infections.

27 male adult patients with acute soft tissue infections including cellulitis, abscesses, ulcers and wound infections were treated with a dose of 2-4 g/day of cefamandole nafate by the intravenous route for a minimum of 10 days. Most patients were seriously ill with underlying conditions like diabetes mellitus, alcoholism and congestive heart failure and required hospitalization and parenteral antibiotics. Gram-positive cocci (predominantly Staphylococcus aureus) and gram-negative bacilli were recovered on pretreatment cultures from 81% of the patients. Clinical and bacteriologic response was excellent. Disappearance of the signs of infection occurred by the 7th day of treatment, by day 3 of treatment fever was down to normal, and by day 5 of treatment the WBC count was below 8,000. There were very few side effects noted, and there was excellent tolerance to the intravenous drug administration. Cefamandole nafate is a safe, effective and well-tolerated agent in the treatment of skin and soft tissue infections of adult patients caused by susceptible organisms.

Adult↗

Amikacin sulfate levels in human serum and bile.

Amikacin levels in blood and bile were measured in 10 patients who underwent cholecystectomy and T-tube drainage. Each patient received 500 mg of amikacin intravenously 12 h preoperatively, during surgery, and every 12 h thereafter for four more doses. Average levels of amikacin in bile were 8.3 micrograms/ml at 1 h after the intraoperative dose, with a bile/serum ratio of 0.44. Postoperative doses at 1 h produced levels in bile of 3.8 to 4.2 micrograms/ml, with a bile/serum ratio of 0.15 to 0.22. Levels in bile decreased at a rate lower than levels in blood, and bile/serum ratios increased from 0.54 at 2 h to 0.93 at 12 h. Amikacin accumulated in bile at 6 h after the intravenous dose.

Adult↗

Pharyngeal flora in ambulatory alcoholic patients: prevalence of gram-negative bacilli.

The pharyngeal flora of a group of ambulatory alcoholic patients was studied and compared with the pharyngeal flora of a control group. Sixty-eight patients were studied, 34 alcoholics and 28 controls. Of the alcoholic patients, 59% had Gram-negative bacilli in their pharyngeal flora, while 14% of the control group had the same organisms. There were no differences in Gram-positive cocci colonization between the groups. Klebsiella pneumoniae was the most frequent isolate (40%) and the Klebsiella-Enterobacter group accounted for 76% of the isolates. Colonization rates of greater than 10 colony forming units/ml were found in 43% of the alcoholic patients. The high prevalence and higher colonization rates of Gram-negative bacilli in alcoholic patients might explain the higher incidence of Gram-negative bacillary pneumonia among alcoholics.

Adult↗

Hantavirus infection: a rare disease which you should be aware.

Hantavirus infection is caused by viruses classified in the Hantavirus genus, of the Bunyaviridae family. Recently a new hantavirus has been recognized. Specific endemic areas has been identified, however a new outbreak was identified in the southwestern of the United States. The principal vectors are rodents. Human infection occur by aerosol from rodent urine, saliva, feces and rodent bites. The infection classically is manifested clinically by fever, hemorrhage and renal failure. The recent outbreak was associated with acute respiratory illness without renal involvement. The treatment is with intravenous Ribavirin. Specific recommendations for prevention and control are presented here in.

Adult↗

[Infections of penile prosthesis: treatment and prevention].

To date, there are 10,000,000 men with impotence in the United States and it is estimated that at least 17,000 penile prosthesis are implanted annually. The most fearsome complication is the infection of the prosthesis which is usually caused by Staphylococcus epidermidis (in 40-80% of the cases). In general, the incidence of infection is actually 0.8-8.3%, but it can increase to 37% in patients with tertiary implants. The initial empiric treatment is usually with vancomycin and aminoglycosides and prophylaxis is recommended with a penicillinase-resistant synthetic penicillins, first generation cephalosporins, or vancomycin in case of penicillin allergy.

Anti-Bacterial Agents↗

Cytomegalovirus retinitis in AIDS patients: a clinical review.

Cytomegalovirus (CMV) retinitis is an ocular condition previously seen in organ transplant recipients, patient on chemotherapy for malignancy, and in infants with congenital infections. As it present in immunocompromised, the AIDS patient has integrated this group of patients that can present with CMV retinitis. Moreover, it is the leading cause of opportunistic ocular infection in the AIDS patient, and the second most common ocular manifestation. As new drugs and modes of administration are studied that can effectively halt this progressively blinding condition, the awareness and recognition of CMV retinitis on AIDS patients has become increasingly important. This author will review the epidemiology, clinical presentation, and differential diagnosis of this condition. The current treatments being used and complications will also be discussed.

Acquired Immunodeficiency Syndrome↗