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C H Roy

Publications and source records attributed to C H Roy.

5 recordsLinked to original sources
PubMed1994

Changes in fetal thyroid hormone levels in adrenalectomized fetal sheep following continuous cortisol infusion 72 h before delivery.

Continuous infusion of cortisol into adrenalectomized fetal sheep during the last 72 h of gestation (term = 145 +/- 2 days) produced a significant (P < 0.05) rise in fetal serum tri-iodothyronine (T3) mean +/- S.E.M. concentrations from 398 +/- 65 to 1340 +/- 238 ng/l. A concurrent decrease in plasma thyroxine (T4) levels was observed in three out of four animals. No significant changes in the concentrations of either hormone were noted prior to the start of cortisol infusion. The plasma concentrations of cortisol, T3 and T4 at term were similar to those in untreated full-term lambs. Adrenalectomized fetuses not given cortisol infusions still had low levels of T3 at term, with no increase being observed. The results suggest that cortisol plays an important role in the increase of fetal plasma T3 observed towards the end of gestation. This is probably achieved by the stimulation of the monodeiodination of T4 to T3 in the peripheral tissues.

Adrenalectomy↗
PubMed1992

A modified helium dilution technique for measuring small lung gas volumes.

The present study was undertaken to devise an accurate method for measuring functional residual capacity, FRC, in small and lively newborn animals such as lambs and piglets under flexible laboratory conditions using relatively simple equipment. This was achieved by adapting the standard helium dilution method so that FRC could be calculated from the helium equilibration concentration reached when the subject, having breathed a gas mixture with a high helium concentration, rebreathed from an air-filled spirometer. Using this technique, typical results for test volumes of 10, 20, 30 and 40 ml were measured as 10.7 +/- 0.34, 20.2 +/- 0.19, 30.5 +/- 0.40 and 40.6 +/- 0.75 ml respectively with corresponding coefficients of variation of 6.4%, 1.9%, 2.6% and 3.7%. Repeat measurements made on each of 3 urethane anaesthetised rabbits gave values for FRC of 45.64 +/- 0.9 ml (5 measurements), 37.22 +/- 0.8 ml (8 measurements) and 48.95 +/- 0.99 ml (8 measurements) confirming the reproducibility of results from animal preparations. The FRC of newborn lambs (12 animals) was 81.4 +/- 9.2 ml. The technique also allowed clear recordings of respiratory pattern essential to the analysis of variations in FRC.

Animals↗