[Research steps of applied medicine].
The history of science in medicine started 1543 with Vesal's book "De corporis humani fabrica". Four hundred years later, in 1955, Braun opened up the enormous unexplored territory of applied medicine for future scientific investigation with his publication "The law of regularly case distribution". As usual in such research work initially the most important tasks were to uncover the inherent laws and to create an appropriate specific terminology.