C H Van Hasselt | PubMed Health

PubMed1986

Neurolept anaesthesia using etomidate as the hypnotic agent.

A technique of neurolept anaesthesia using etomidate (Hypnomidate; Janssen) instead of nitrous oxide is described in which a continuous infusion of 1 mg/kg/h is used to supplement droperidol, fentanyl and alcuronium. This totally intravenous technique eliminates theatre pollution, may offer haemodynamic stability and may be of use in patients with raised intracranial pressure. Pain on injection and muscle movements which occur with etomidate administration do not detract from the value of this technique.

Adolescent↗

PubMed1975

Intravenous ketamine for postoperative analgesia.

Thirty-six consecutive patients who had undergone major surgery were carefully studied for 6 hours postoperatively in an attempt to evaluate the relative analgesic and respiratory-depressant effect of morphine, ketamine, and placebo administered by continuous intravenous infusion. Side-effects, vital signs and respiratory measurements were recorded hourly by a consultant physician. With regard to the dosage and method of administration, ketamine was shown to be less effective than morphine for the first 3 hours postoperatively, but equally effective subsequently, whereas the patients who received ketamine showed a greater progressive tendency for their respiratory parameters to improve with time. Recommendations regarding the postoperative control of pain are made, and the need for further study is noted.

Clinical Trials as Topic↗