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Biomedical subjects

C Hagerty

Publications and source records attributed to C Hagerty.

10 recordsLinked to original sources
PubMed1995

Cortical blindness after correction of symptomatic hyponatremia: dynamic cerebral dysfunction visualized using serial SPECT scanning.

A 70-yr-old woman developed cortical blindness after correction of hyponatremia. Regional hyperperfusion was noted on SPECT scans obtained in the acute phase. One month later when symptoms had largely resolved, a repeat examination was normal. This regional hyperperfusion, which was not associated with any apparent structural damage, may have represented either luxury perfusion or a transient increased metabolic requirement of the dysfunctional cortical area. SPECT scanning may be a useful method to study cerebral dysfunction resulting from an osmotic disturbance.

Aged↗
PubMed1989

Precision and reproducibility of quantitative coronary angiography with applications to controlled clinical trials. A sampling study.

Most computer methods that quantify coronary artery disease from angiograms are designed to analyze frames recorded during the end-diastolic portion of the cardiac cycle. The purpose of this study was to determine if end diastole is the best portion of the cardiac cycle to sample, or if other sampling schemes produce more precise and/or reproducible estimates of coronary disease. 20 cinecoronary angiograms were selected at random from a controlled clinical trial testing the effects of plasma lipid lowering on atherosclerosis. Sampling schemes included sequential and random sampling of two to five frames within the complete cardiac cycle, systole, and diastole. Three vessel measures and percent stenosis were evaluated for each sampling scheme. From the sampling experiment, it was determined that sampling sequentially end diastole yielded the most precise estimates (i.e., exhibiting minimum variability within a cycle) of the vessel measures. With regard to reproducibility (i.e., similar values across cycles), sampling randomly within the cycle was best. Overall, the average diameter of a vessel segment was the most precise and the most reproducible of the measures. Sample size calculations are given for each of these measures under the best sampling scheme.

Algorithms↗
PubMed1987

A microcomputer-based distributed data management system for a large cooperative study of transfusion associated acquired immunodeficiency syndrome.

This paper describes the details of a microcomputer-based, distributed data management system in the acquisition of data collected in a large multicentered cooperative investigation of transfusion-transmitted acquired immunodeficiency syndrome (AIDS). Clinical, virological, and immunological data are obtained from six clinical centers and six central laboratories using a variety of hardware components and software packages. Data are merged and processed on a mainframe computer at the Biostatistics Office at the University of Southern California. The advantages and disadvantages of this system are discussed relative to the dynamics of the study, the magnitude and nature of the database, and the organization of the distributed centers involved.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Immunopathology of acute experimental histoplasmic choroiditis in the primate.

The immunopathologic features of experimental acute histoplasmic choroiditis were studied in the nonhuman primate. Using an indirect immunoperoxidase technique, a panel of hybridoma-derived anti-human monoclonal antibodies, recognizing distinct lymphoid cell and macrophage surface antigens, have been adapted for use in the primate system. Twenty-two individual foci of histoplasmic choroiditis from five eyes were studied at time periods from 20 to 60 days post intracarotid injection of yeast phase Histoplasma capsulatum. A mononuclear and granulocytic cell infiltration was seen in all lesions. The predominant cell type was the CAPPEL+ T lymphocyte (suppressor/cytotoxic subset). Other cell types found in smaller numbers were OKT4+ T cells (helper/inducer subset), OK7+ (peripheral B lymphocytes), IgD+ (mantle B cells) and OKM1+ cells (macrophages and polymorphonuclear leukocytes). Herein, we present immunopathologic data on the acute phase of experimental ocular histoplasmosis.

Acute Disease↗