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C Hakim

Publications and source records attributed to C Hakim.

13 recordsLinked to original sources
PubMed2001

The ability of helical CT to preoperatively stage endometrial carcinoma.

OBJECTIVE: This study evaluated helical CT as an imaging modality for preoperative staging of endometrial carcinoma. MATERIALS AND METHODS: Three radiologists retrospectively and independently reviewed the preoperative helical CT scans of 25 consecutive patients with endometrial carcinoma. The presence or absence of deep myometrial invasion and the presence or absence of cervical involvement were evaluated on helical CT and compared with pathologic findings at hysterectomy. RESULTS: Helical CT has a sensitivity of 83% and a specificity of 42% for the detection of deep myometrial invasion (stage IC). Helical CT has a sensitivity of 25% and a specificity of 70% for the detection of cervical involvement (state II). These results compare poorly with those of MR imaging (sensitivity 92%, specificity 90% for the detection of deep myometrial invasion; sensitivity 86%, specificity 97% for the detection of cervical involvement). CONCLUSION: Helical CT is insensitive and nonspecific compared with MR imaging for the preoperative staging of endometrial carcinoma. MR imaging remains the imaging modality of choice.

Aged↗
PubMed1999

FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation.

Hematopoietic cell growth, differentiation, and commitment to a restricted lineage are guided by a set of cytokines acting exclusively on cells expressing the corresponding cytokine receptor. The macrophage colony stimulating factor (M-CSF, also termed CSF-1) and its cognate receptor, the tyrosine kinase c-Fms, are essential for monocyte and macrophage development. The underlying molecular mechanism, however, is poorly understood. Here we identified a novel Fms-interacting protein (FMIP, MW 78 kDa) which binds transiently via its N-terminal 144 residues to the cytoplasmic domain of activated Fms-molecules. Binding of FMIP was paralleled by rapid tyrosine phosphorylation within the binding domain which drastically reduced its ability to associate with Fms. Binding was specific as evidenced by co-immunoprecipitation and association with recombinant GST-Fms fusion proteins. No binding was observed with the tyrosine phosphorylated cytoplasmic domains of c-Kit, TrkA, c-Met, and the insulin receptor. The role of FMIP in hematopoietic differentiation was studied in the bipotential myeloid progenitor cell line, FDC-P1Mac11. Overexpression of FMIP prevented M-CSF induced macrophage differentiation. Instead, cells differentiated into granulocytes. Our data suggest that the level of FMIP expression could form a threshold that decides about differentiation either into macrophages or into granulocytes.

Amino Acid Sequence↗
PubMed1996

Dermatologic findings in HIV-1-infected patients: a prospective study with emphasis on CD4+ cell count.

BACKGROUND: Skin manifestations are common in patients infected with the human immunodeficiency virus (HIV) but the prognostic significance of may of them is not clear. METHODS: Skin disorders were studied in a cohort of 267 HIV-infected patients followed prospectively and were correlated to the CD4+ cell count. RESULTS: Among the most specific to HIV infection, Kaposi's sarcoma, oral hairy leukoplakia, molluscum contagiosum, xerosis and oral candidiasis were statistically associated to a low CD4+ cell count (200-300 CD4+/mm3; p < 0.001). Kaposi's sarcoma, oral candidiasis and molluscum contagiosum were more frequent in homosexual males (p < 0.05). Genital warts were more frequent in intravenous-drug users (p < 0.001). CONCLUSIONS: These results suggest that dermatological findings are useful clinical predictors of the presence or progression of HIV infection.

Adult↗
PubMed1995

Five feminist myths about women's employment.

Feminist sociology has contributed substantial revisions to theory, especially in the sociology of work and employment. But it is also creating new feminist myths to replace the old patriarchal myths about women's attitudes and behaviour. Five feminist myths about women's employment are discussed whose acceptance as fact is not damaged by being demonstrably untrue. Arguably the most pervasive is the myth of rising female employment. The myth that women's work commitment is the same as that of men is often adduced to resist labour market discrimination. The myth of childcare problems as the main barrier to women's employment is commonplace in advocacy research reports. The myth of poor quality part-time jobs is used to blame employers for the characteristic behaviour of part-time workers, including high labour turnover. The issue of the sex differential in labour turnover and employment stability illustrates clearly how feminist orthodoxy has replaced dispassionate sociological research in certain topics. The concluding section considers the implications of such feminist myths for an academic community that claims to be in the truth business and for theories on the sexual division of labour.

Adolescent↗
PubMed1992

[Dysthymic schizophrenia. Reality or fiction?].

After an historical survey about the origin and the evolution of the concept of schizo-affective psychosis (i.e. in French schizophrénie dysthymique), a review of the recent bibliography reveals that the different models of classification are a subject for discussion. Studies tend to corroborate the model of an heterogeneous group with schizophrenic patients and manic-depressive patients.

Bipolar Disorder↗
PubMed1986

Subclinical autoimmune disease and recurrent spontaneous abortion.

We describe a patient with no clinical complaints except 5 unexplained spontaneous abortions in whom investigations revealed a positive antinuclear factor, antibodies to native double-stranded DNA, LE cells, a positive Coombs' test, a positive lupus anticoagulant test, and anticardiolipin antibodies. Despite preeclampsia our patient successfully completed her 6th pregnancy after treatment with corticosteroids, subcutaneous heparin, and low dose aspirin throughout the pregnancy. Serial measurements of anticardiolipin antibody showed suppression of anticardiolipin antibody levels with corticosteroids. The response of the lupus anticoagulant was less obvious. No anticardiolipin antibodies were detected in the baby.

Abortion, Habitual↗
PubMed1984

Chronic traumatic tricuspid insufficiency.

Isolated tricuspid insufficiency (TI) is relatively uncommon and mostly of traumatic origin. We report clinical noninvasive and invasive findings and surgical results in 5 cases. All patients had complete clinical, noninvasive and invasive studies including right and left catheterization, and coronary angiographies in 3 patients. All but 1 patient had nonpenetrating trauma. All had large jugular V waves, right precordial impulse, systolic liver pulse, positive Carvallo sign documented also by noninvasive techniques. Right heart failure was present in 3 patients. Chest x-ray showed prominent right atrium and distended vena cavae. Electrocardiogram showed normal sinus rhythm in 4 patients and atrial fibrillation in 1. Two patients had right bundle-branch block, and 2 presented RSR'-pattern. Echocardiogram showed large right atrium (RA) (6-10 cm), floppy tricuspid valve (TV) in all, dilated right ventricle (RV) in 2 patients. Findings of left heart were normal in all. Three patients had right-to-left shunt. In RA A waves were 4-8, Y waves 1-3, and V waves 12-22 mmHg, respectively (mean RV and PA pressures were 23/3 and 23/10 mmHg, respectively). Four patients had anuloplasty, 2 of them repair of valve and chordae. Surgical results were good in 2 patients with valve repair, satisfactory in 1; there was significant TI resistance in 1 case. We conclude that TI has distinctive clinical findings and must be ruled out in all patients with chest trauma. Surgery must include not only anuloplasty, but, cusps and chordae must also be evaluated and reconstructed if necessary.

Electrocardiography↗
PubMed1984

Data dissemination for the population census.

"Recent developments in the data-dissemination system for census of population statistics are reviewed, with particular reference to Great Britain. Key issues discussed include: the expansion of census output and the need for summaries of census results; the significance of consultation with census users; the development and functions of guides for census users; the emergence of data-dissemination centres and archives offering new services; the functions of area typologies as a new type of census by-product; the demand for Public Use Samples and the problem of confidentiality; and the emergence of large-scale surveys as alternatives to the census."

Censuses↗
PubMed1982

The social consequences of high unemployment.

Forecasts suggest that unemployment will remain above 2 million in Britain for the best part of the 1980s. The social consequences of protracted high levels of unemployment are explored. The evidence comes from four types of source: cross-sectional surveys of (unemployed) individuals; longitudinal and cohort studies; aggregate time series; and area-based studies. The advantages and limitations of each are identified. The available evidence on the consequences of unemployment for poverty; health and mortality; mental health; crime and delinquency; and the social fabric is reviewed. The implications for policy and public expenditure are explored.

Crime↗
PubMed1978

Significance of detection of extra metacentric microchromosome in amniotic cell culture.

A metacentric bisatellited microchromosome was detected in all metaphases from an amniotic culture performed because of maternal age. A wide-ranging survey of the literature failed to disclose any consistent anomaly associated with such a marker, but did reveal that the clinical picture of patients manifesting it could range from complete normality through mental retardation to a variety of deformities. The parents elected for termination, and the only deformity detected in the abortus was fixed talipes equinovarus. The implications of the finding of this marker chromosome on amniocentesis, believed to be reported for the first time here, are discussed particularly in the context of genetic counselling.

Adult↗