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Biomedical subjects

C Halde

Publications and source records attributed to C Halde.

13 recordsLinked to original sources
PubMed1985

Phaeohyphomycotic cyst of the skin caused by Exophiala jeanselmei.

A dermosubcutaneous nodule presenting with a superficial papular vascular component occurred in a man receiving long-term prednisone therapy. The histologic findings were characteristic of a phaeohyphomycotic cyst, and a black mold, Exophiala jeanselmei, was isolated. Despite treatment with ketoconazole and local heat, the lesion persisted and was excised. The fungus could be seen in the excised tissue, but cultures were sterile. Subcutaneous phaeohyphomycosis is a relatively uncommon, but recently more frequently recognized type of opportunistic fungus infection.

Cysts↗
PubMed1983

Passive immunization in murine mucormycosis.

Antibody raised in mice against mycelial homogenates of Rhizomucor pusillus was effective in passive immunization against pulmonary and disseminated mucormycosis (phycomycosis) in immunocompromised mice. Mice intranasally inoculated and infected with Rh. pusillus and treated with antisera had a statistically significant increased resistance to infection and a diminished secondary dissemination of viable fungal fragments. Histological examination of infected lung tissues showed that antibody treated animals were apparently able to degrade hyphal fragments.

Animals↗
PubMed1983

Immunodiffusion and complement fixation assays with sera from mucormycotic-infected mice.

Results using homogenate antigens of Rhizomucor pusillus against immunized rabbit sera, mouse ascites fluid and sera from mucormycotic-infected mice, detected by immunodiffusion and complement fixation assays are presented. Using immunodiffusion techniques, common antigens and unique antigens from Rh. pusillus, Rhizopus oryzae and Absidia corymbifera were observed. Complement fixation titers of greater than 256 and 128 were obtained in immunized rabbit sera and mouse ascites fluid, respectively. However, no appreciable titers of antibody were measured from mucormycotic-infected animals by either immunodiffusion or complement fixation.

Animals↗
PubMed1982

Murine model of pulmonary mucormycosis in cortisone-treated mice.

Intranasal inoculation of Rhizomucor pusillus sporangiospores into cortisone-treated mice produced pulmonary and disseminated mucormycosis (phycomycosis). Evidence for infection in cortisone treated mice was obtained by recovery of Rh. pusillus from homogenates of tissue. Confirmation of infection was shown histologically. The 50% infectious dose was 2.4 x 10(2) colony forming units for lung infections and 2.7 x 10(5) colony forming units for brain infections. No evidence of sporangiospore germination was found in tissues of non-cortisone-treated mice although sporangiospores were found throughout pulmonary tissues. In infected tissues of cortisone-treated mice, hyphae were covered with leukocytes and tissue necrosis was extensive.

Animals↗
PubMed1978

Botryomycosis: first report of human brain involvement.

A 57-year-old man, previously well except for dental caries and a history of Wolff-Parkinson-White syndrome, presented with marching right-sided motor seizures of sudden onset. Cerebral arteriography and scan demonstrated an avascular left frontal lobe mass. At operation, it was identified as an abscess and was totally excised. Histologically, granules resembling those seen in actinomycosis were demonstrated in the abscess wall, but special stains revealed gram-positive cocci in chains within and outside the granules. Fungal spores, mycelia, or branching filamentous structures were absent. Acid-fast stains were negative, and alpha-hemolytic streptococcus was recovered in pure culture from the abscess. While the patient was convalescing with penicillin therapy, a dental survey revealed the presence of periodontal abscesses which were drained by exodontia. Culture of the tooth sockets showed alpha-hemolytic streptococcus and Staphylococcus aureus. The literature on this relatively rare bacterial disease which histologically resembles actinomycosis is reviewed.

Actinomycosis↗
PubMed1977

Keratitis and endophthalmitis caused by Petriellidium boydii.

A 26-year-old man sustained burns of the left eye and eyelids from molten aluminum. Antimicrobial and anti-inflammatory therapy was instituted. Cultures of conjunctival material collected 14 days after the burn grew abundant colonies of Petriellidium boydii. Because of severe pain and impending corneal perforation, the eye was enucleated.

Adult↗
PubMed1976

Acremonium falciforme as a cause of mycetoma in California.

Three cases of mycetoma were studied in the San Francisco Bay area of northern California during the period from 1960 to 1973. In each case the causal agent was identified on the basis of the histological structure of the granules and by isolation of the etiological agent in pure culture. The fungus in all cases was found to be Acremonium falciforme. This is the first report of A. falciforme occurring as a disease agent in the United States.

Adult↗
PubMed1975

Mycotic flora of the interdigital spaces of the human foot: a preliminary investigation.

A qualitative and quantitative study of the mycotic flora of the interdigital spaces of 27 male volunteers yielded 1,291 moulds and 598 yeasts. Concurrently, a study of garden soil was conducted in order to obtain data concerning the transient-resident status of the fungi recovered from the feet. Of the 120 genera and species of fungi isolated, 51 were recovered from the volunteers, 53 from the soil, and 16 from both categories. The most commonly recovered fungi from the toewebs, in order to occurrence, were Torulopsis candida, Mycelia Sterilia, T. maris, Rhodotorula rubra, Cryptococcus albidus, and species of Aspergillus and Penicillium. Without sign of infection, Cryptococcus neoformans was isolated from 5 volunteers. Candida albicans was not recovered from any subject. Trichophyton mentagraphytes was recovered from 7 volunteers and T. rubrum from one.

Adult↗
PubMed1966

Cryptococcus neoformans in pigeon feces in San Francisco.

Typical Cryptococcus neoformans was isolated from one of 10 specimens of pigeon feces collected in downtown San Francisco. This isolation from a small sample suggests considerable prevalence of this important pathogen and tends to confirm that it is ubiquitous.

Animals↗